2014
DOI: 10.3389/fimmu.2014.00156
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The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First?

Abstract: All mature blood cells derive from hematopoietic stem cells through gradual restriction of their cell fate potential and acquisition of specialized functions. Lineage specification and cell commitment require the establishment of specific transcriptional programs involving the activation of lineage-specific genes and the repression of lineage-inappropriate genes. This process requires the concerted action of transcription factors (TFs) and epigenetic modifying enzymes. Within the hematopoietic system, B lympho… Show more

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Cited by 44 publications
(29 citation statements)
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“…ellular differentiation requires so-called master or pioneering transcription factors (TFs) to establish access to regulatory elements embedded in chromatin 1 . Similar to the vast majority of TFs, they usually recognize specific DNA motifs ranging from 6 to 12 base pairs (bp) in length, implying the existence of roughly a million potential binding sites throughout the genome 2 .…”
mentioning
confidence: 99%
“…ellular differentiation requires so-called master or pioneering transcription factors (TFs) to establish access to regulatory elements embedded in chromatin 1 . Similar to the vast majority of TFs, they usually recognize specific DNA motifs ranging from 6 to 12 base pairs (bp) in length, implying the existence of roughly a million potential binding sites throughout the genome 2 .…”
mentioning
confidence: 99%
“…Regulation of enhancer accessibility to TFs is an area of intense interest. Some TFs, such as PU.1, IKZF1 (Ikaros), and EBF1, can invade enhancers occupied by nucleosomes and, either singly or in combination, open the enhancers to subsequent TFs 17 – 19 . In some cases, these pioneering TFs open enhancers by recruiting histone methyltransferases and acetyltransferases 19 .…”
Section: Introductionmentioning
confidence: 99%
“…B cell development is controlled by the interplay of a cohort of transcription factors (TFs) and DNA cis-regulatory elements (cis-REs) 4 5 6 . This interaction is crucial to establish transcriptional programs specific to each differentiation stage.…”
mentioning
confidence: 99%