The interplay between Epstein-Barr virus DNA and gut microbiota in the development of arthritis in a mouse model

Fadlallah, Sukayna; Bitar, Elio R.; Hussein, Hadi; Jallad, Mary-Ann; Matar, Ghassan M.; Rahal, Elias A.

doi:10.1128/spectrum.02042-23

Cited by 4 publications

(2 citation statements)

References 60 publications

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“…Leaky gut syndrome aka dysbiosis is associated with autoimmune disease [12,13,14] and is linked to LC [15,16]. Gut dysbiosis has been associated with other viral infections linked to subsequent autoimmune disease, e.g., EBV [17]. Leaky gut syndrome stimulates autoimmune pathogenesis.…”

Section: Lc Gut Dysbiosis and Autoimmune Diseasementioning

confidence: 99%

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

W. Chambers

2024

JNNS

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The dermatological manifestations of Long Covid (LC) have languished in the shadows of chronic fatigue and brain fog. Yet they are all linked by gut dysbiosis and the cytokine triad of TNF-α, IL-1β, and IL-6. The gut microbiome common not only to LC, psoriasis, AA, and vitiligo but also to neurodegenerative disease has been recently described. This gut microbiome induces an altered tryptophan metabolism linked to autoimmune disease. SARS CoV2, Mycobacteria, and many intestinal parasites protectively upregulate IFN-γ (less Covid in BCG and in subSaharan Africa), triggering the characteristic altered tryptophan metabolism and curtailing synthesis of serotonin and melatonin. Chronic inflammation due to persistent spike protein S exhausts IFN-γ and leads to gut dysbiosis and autoimmune risk. Butyrate immunomodulates IFN-γ and TGF-β, which counterbalance each other (reciprocal relationship). Low IFN-γ (LC) translates to high TGF-β (organ fibrosis). This review suggests that an etiologic prebiotic (d-mannose)/probiotic (lactobacilli, bifidobacteria)/postbiotic (butyrate) approach to autoimmune skin disease that improves intestinal barrier integrity and that suppresses the triad of TNF-α, IL-6, and IL-1β may enhance or even eliminate the traditional immunotherapy of targeted monoclonal antibodies, Janus kinase inhibitors, and steroids. Health benefits of this approach extend well beyond suppression of autoimmune skin disease. Societal benefits include relief to those most affected - women (LC), especially of color (AA, psoriasis, vitiligo).

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Section: Lc Gut Dysbiosis and Autoimmune Diseasementioning

confidence: 99%

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

W. Chambers

2024

JNNS

View full text Add to dashboard Cite

show abstract

“…Leaky gut syndrome aka dysbiosis is associated with autoimmune disease 12,13,14 and is linked to LC 15,16 . Gut dysbiosis has been associated with other viral infections linked to subsequent autoimmune disease, e.g., EBV 17 . Leaky gut syndrome stimulates autoimmune pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

Chambers,

Chambers

2023

Preprint

View full text Add to dashboard Cite

The dermatological manifestations of Long Covid (LC) have languished in the shadows of chronic fatigue and brain fog. Yet they are all linked by gut dysbiosis and the cytokine triad of TNF-α, IL-1β, and IL-6. The gut microbiome common not only to LC, psoriasis, AA, and vitiligo but also to neurodegenerative disease has been recently described. This gut microbiome induces an altered tryptophan metabolism linked to autoimmune disease. SARS CoV2 invades enterochromaffin cells rich in ACE2 receptors and curtails absorption of the essential amino acid tryptophan and subsequent synthesis of serotonin and melatonin. This review suggests that an etiologic prebiotic (d-mannose)/probiotic (lactobacilli, bifidobacteria)/postbiotic (butyrate) approach to autoimmune skin disease that improves intestinal barrier integrity and that suppresses the triad of TNF-α, IL-6, and IL-1β may enhance or even eliminate the traditional immunotherapy of targeted monoclonal antibodies, Janus kinase inhibitors, and steroids. Health benefits of this approach extend well beyond suppression of autoimmune skin disease.

show abstract

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

Chambers

2023

Preprint

View full text Add to dashboard Cite

The dermatological manifestations of Long Covid (LC) have languished in the shadows of chronic fatigue and brain fog. Yet they are all linked by gut dysbiosis and the cytokine triad of TNF-α, IL-1β, and IL-6. The gut microbiome common not only to LC, psoriasis, AA, and vitiligo but also to neurodegenerative disease has been recently described. This gut microbiome induces an altered tryptophan metabolism linked to autoimmune disease. SARS CoV2 invades enterochromaffin cells rich in ACE2 receptors and curtails absorption of the essential amino acid tryptophan and subsequent synthesis of serotonin and melatonin. This review suggests that an etiologic prebiotic (d-mannose)/probiotic (lactobacilli, bifidobacteria)/postbiotic (butyrate) approach to autoimmune skin disease that improves intestinal barrier integrity and that suppresses the triad of TNF-α, IL-6, and IL-1β may enhance or even eliminate the traditional immunotherapy of targeted monoclonal antibodies, Janus kinase inhibitors, and steroids. Health benefits of this approach extend well beyond suppression of autoimmune skin disease.

show abstract

The interplay between Epstein-Barr virus DNA and gut microbiota in the development of arthritis in a mouse model

Cited by 4 publications

References 60 publications

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

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