The interplay between lipid droplets and virus infection

Qu, Yafei; Wang, Weili; Xiao, Maggie Z X; Zheng, Yuejuan; Liang, Qiming

doi:10.1002/jmv.28967

Cited by 4 publications

(4 citation statements)

References 173 publications

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“…Viral infections impact the lipid metabolism in several pathosystems: some viruses trigger the accumulation of lipid droplets while others reduce the lipid storage (Qu et al, 2023). OrV infection leads to a significant reduction in lipid accumulation, even though OrV itself relies on lipids for effective infection (Casorla-Perez et al, 2022).…”

Section: Influence Of Orv On Lipid Metabolism the Upr Mt And The Inos...mentioning

confidence: 99%

Story of an infection: viral dynamics and host responses in theCaenorhabditis elegans-Orsay virus pathosystem

Castiglioni,

Olmo-Uceda,

Villena-Giménez

et al. 2023

Preprint

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SUMMARYOrsay virus (OrV) is the only known natural virus affectingCaenorhabditis elegans, with minimal impact on the worm’s fitness due to its robust innate immune response. This study aimed to understand the interactions betweenC. elegansand OrV by tracking the infection’s progression during larval development. Four distinct stages of infection were identified based on viral load, with a peak in capsid- encoding RNA2 coinciding with the first signs of viral egression. Transcriptomic analysis revealed temporal changes in gene expression and functions induced by the infection. A specific set of up- regulated genes remained active throughout the infection, and genes correlated and anticorrelated with virus accumulation were identified. Responses to OrV mirrored reactions to other biotic stressors, distinguishing between virus-specific responses and broader immune responses. Additionally, mutants of early response genes and defense-related processes showed altered viral load progression, uncovering new players in the antiviral defense response.

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Section: Influence Of Orv On Lipid Metabolism the Upr Mt And The Inos...mentioning

confidence: 99%

Story of an infection: viral dynamics and host responses in theCaenorhabditis elegans-Orsay virus pathosystem

Castiglioni,

Olmo-Uceda,

Villena-Giménez

et al. 2023

Preprint

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“…A kinetic study on lipidome changes in HCV (strain 96/JFH-1)-infected human hepatoma Huh-7 cells using mass spectrometry discovered a dynamic profile, with phosphatidyl phospholipids, triacylglycerol, phosphatidyl choline and ceramide derivatives being enriched early in infection, and free fatty acids, phosphatidylethanolamine peaking at late stages of the replication cycle. This profile could be correlated with different lipidome functions during viral replication (Islam et al, 2023;Qu et al, 2023).…”

Section: Other Rna Virusesmentioning

confidence: 93%

Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses

Desselberger

2024

Preprint

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The replication of species A rotaviruses (RVAs) and other RNA viruses involves recruitment of and inter-action with the cellular organelles lipid droplets (LDs), both physically and functionally. Inhibition of en-zymes involved in the cellular fatty acid biosynthesis pathway or of cellular lipases that degrade LDs re-duces the functions of ‘viral factories’ (viroplasms for rotaviruses or replication compartments of other RNA viruses) and decreases the production of infectious progeny virus. Similarly, disturbance of the cellular lipid homeostasis in various ways blocks the replication of flaviviruses (hepatitis C viruses, Zikavirus, others), HIV-1, SARS-CoV-2, picornaviruses, noroviruses, influenza viruses and other negative-strand RNA viruses.

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“…While the replication cycles of many RNA and DNA viruses have been well researched, it has only relatively recently been recognized that various cellular lipids are involved in many of the viral replication steps [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Analogous data have been acquired for many other RNA viruses. The fact that the disturbance of cellular lipid metabolism decreases the yield of infectious viral progeny for many viruses has made the search for lipid-disturbing compounds an attractive aim for the development of broadly active candidate antivirals [ 1 , 5 , 6 , 7 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses

Desselberger

2024

Viruses

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The replication of species A rotaviruses (RVAs) involves the recruitment of and interaction with cellular organelles’ lipid droplets (LDs), both physically and functionally. The inhibition of enzymes involved in the cellular fatty acid biosynthesis pathway or the inhibition of cellular lipases that degrade LDs was found to reduce the functions of ‘viral factories’ (viroplasms for rotaviruses or replication compartments of other RNA viruses) and decrease the production of infectious progeny viruses. While many other RNA viruses utilize cellular lipids for their replication, their detailed analysis is far beyond this review; only a few annotations are made relating to hepatitis C virus (HCV), enteroviruses, SARS-CoV-2, and HIV-1.

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The interplay between lipid droplets and virus infection

Cited by 4 publications

References 173 publications

Story of an infection: viral dynamics and host responses in theCaenorhabditis elegans-Orsay virus pathosystem

Story of an infection: viral dynamics and host responses in theCaenorhabditis elegans-Orsay virus pathosystem

Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses

Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses

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