The interplay between monosodium glutamate (MSG) consumption and metabolic disorders

Kayode, Omowumi T.; Bello, Jemilat A.; Oguntola, Jamiu A.; Kayode, Abolanle A.A.; Olukoya, Daniel K.

doi:10.1016/j.heliyon.2023.e19675

Cited by 10 publications

(4 citation statements)

References 76 publications

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“…Elevated oxidative stress levels, as seen in DM, can potentially lead to cellular damage within the taste buds, disrupting their normal function and possibly leading to taste disorders [42]. The mitochondrial antioxidant enzymes, by counteracting oxidative stress, help maintain a conducive cellular environment within the taste buds, thus preserving taste perception [43]. This is particularly pertinent considering the adverse impact of taste disorders on nutritional intake and the overall quality of life of individuals with DM [13,35].…”

Section: Discussionmentioning

confidence: 99%

4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

Gaida,

Park,

Kim

2023

Applied Sciences

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Taste perception plays a crucial role in health and well-being but can be compromised by conditions such as diabetes mellitus (DM). This study delved into the efficacy of 4-hexylresorcinol (4-HR) in mitigating taste bud apoptosis, particularly in relation to DM-induced taste issues. Two primary rat groups were investigated: healthy rats and streptozotocin (STZ)-induced diabetic rats. Each group was further divided into control and experimental subsets, with the experimental group receiving 4-HR injections. A histological analysis of the circumvallate papillae (CVP) highlighted significant taste bud deterioration in the STZ subgroup, including loss of cellular content and a deviation from their typical morphology. Quantitatively, the control group had a mean of 39.6 ± 14.3 taste bud pores/mm2, contrasting with the 4HR, STZ, and STZ/4HR groups, which had means of 33.7 ± 14.2, 20.3 ± 6.1, and 28.0 ± 8.3, respectively. Additionally, a TUNEL assay and IHC staining for c-caspase-3 both identified increased apoptotic cells in the STZ subgroup, with the mean number of apoptotic cells per taste bud profile being notably higher in the STZ group at 3.2 ± 1.6. This study underscores the profound impact of diabetes on taste bud physiology and the potential therapeutic benefits of 4-HR. Further research is essential to delve deeper into its mechanisms and to ascertain optimal dosages, with the aim of enhancing the quality of life of diabetic patients.

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Section: Discussionmentioning

confidence: 99%

4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

Gaida,

Park,

Kim

2023

Applied Sciences

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“… 65 , 66 Although international regulatory agencies (US Food and Drug Administration; FDA, the European Food Safety Association; EFSA, and Joint FAO/WHO Expert Committee on Food Additives; JECFA) evaluate MSG as a GRAS (generally recognized as safe) substance with established limits, 67 , 68 mentioned preclinical studies emphasize that MSG exposure, especially with chronic consumption, causes many different organ toxicities and therefore poses a real health risk. 8 , 69 Some authors argue that this paradigm has emerged because GRAS determination criteria and methodologies, especially for experience‐based procedures, have not been updated in accordance with today's toxicity determination tests and technologies. 70 , 71 , 72 …”

Section: Discussionmentioning

confidence: 99%

Bioinformatics‐based identification of hepatocellular carcinoma‐associated hub genes and assessment of the restorative effect of tannic acid in rat liver exposed to monosodium glutamate

Tosun,

Karadas,

Ceylan

2024

Cancer Medicine

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BackgroundHepatocellular carcinoma (HCC) is the most common type of primary liver cancer, occurring mostly in individuals with chronic liver disease, but biomarkers for therapeutic diagnosis and prognosis are lacking. This study aimed to investigate the possible effect of the common food additive monosodium glutamate (MSG) and tannic acid (TA), a phenolic compound, on the key molecular actors responsible for HCC development.MethodsEight HCC‐related public microarray datasets (GSE84005, GSE14520, GSE25097, GSE57958, GSE22058, GSE84402, GSE54238, and GSE36376) were extracted from the gene expression omnibus (GEO) database and analyzed to identify differentially expressed genes (DEGs). To make sense of the identified biological data and to identify hub genes, protein–protein interaction (PPI) network and enrichment analysis were performed. The mRNA expression profiles of the identified hub genes, expression changes in different stages of HCC, and their prognostic significances in HCC were determined using GEPIA, UALCAN, and Kaplan–Meier Plotter databases, respectively. Finally, mRNA expression changes of identified hub genes in the liver tissues of rats treated with MSG and TA were measured by the quantitative real‐time PCR (qPCR) method.ResultsTwo up‐regulated (AURKA and CCNB2) and two down‐regulated (F9 and CYP2E1) genes were identified between the HCC tumor and adjacent non‐tumor liver tissue samples. qPCR results showed that the mRNA expression of up‐regulated DEGs involved in HCC development increased significantly in rat liver tissues exposed to MSG, while this increase was remarkably suppressed by TA treatment. It was observed that the mRNA expressions of down‐regulated DEGs involved in HCC development decreased markedly in the presence of MSG, while this decrease was alleviated with TA.ConclusionOur results provide new insights into pivotal molecular candidates that should be focused on in future in vivo and in vitro HCC research. Moreover, MSG may play a crucial role in HCC development and progression and TA may be used as a favorable restorative agent in HCC.

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“…The metabolic journey of glutamate within the gastrointestinal tract adds a layer of complexity to its perplexing role. Moreover, the inclusion of additional minerals in MSG salts contributes to a metallic and umami flavour, with sodium glutamate exhibiting superior solubility and crystallization rates, accentuating the intricate sensory experience associated with its consumption [7]. In terms of production methods and metabolism, genetically modified bacteria have been employed since 1957 in the United States to produce MSG from sources such as sugarcane molasses and carbohydrates like corn, showcasing the technological business in its manufacturing [8].…”

Section: Introductionmentioning

confidence: 99%

A Study on the Awareness and Perceptions Regarding Monosodium Glutamate and its Potential Health Effects Amongst the Urban Population of Saudi Arabia

Sheriff,

Abusabah,

Sindi

et al. 2023

Cureus

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IntroductionMonosodium glutamate (MSG), a common global food additive in processed foods, influences flavors and textures due to its chemical complexity and nutritional intricacy. Despite an annual production of 1.9 million tons and historical safety concerns, the multifaceted impact on health, ranging from metabolic disorders to neurological and cardiovascular implications, necessitates ongoing research for informed consumption and balanced dietary practices. Materials and methodsThis cross-sectional study investigates MSG-associated intricacies among Saudi Arabia's urban population. The research included questionnaire development, translation, and cultural adaptation, and was validated by nutrition experts. A sample size of 420 was calculated for a 95% confidence level. Data collection occurred from September 13 to October 31, 2023, and ethical considerations were ensured. Statistical analysis, including chi-square tests, regression analysis, and SPSS, explored intricacy relationships. ResultsThe MSG intricacy study in Saudi Arabia's urban population, involving 420 respondents, showed statistically significant correlations (P < 0.05) in demographics. The key findings indicate an awareness of the impact of MSG on health, its associations with various conditions, and strong support for its exclusion from foods. Region, gender, age, and social status correlations highlighted diverse perspectives. The Western province showed the highest response rate at 42.61%, prompting regional awareness questions. Gender dynamics showed that 90.47% of the respondents were females, emphasizing potential gender-specific concerns. Concentration among ages 20-30 (61.9%) underscored generational factors. While commendable baseline awareness was noted, 73.09% of the participants believing MSG is harmful prompts further investigation. Emotional responses, including happiness (25.95%) and frustration (18.33%), highlight the complexity of the individuals' experiences, emphasizing the need for tailored communication strategies. ConclusionThe MSG intricacy study in Saudi Arabia's urban population reveals insights into knowledge, attitudes, and behaviors, emphasizing the need for nuanced interventions considering regional and emotional differences. The findings underscore health concerns, supporting regulations, and knowledge impact on behavior. This survey serves as a valuable tool for informed public discourse and decision-making in the unique sociocultural context of urban Saudi Arabia.

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The interplay between monosodium glutamate (MSG) consumption and metabolic disorders

Cited by 10 publications

References 76 publications

4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

Bioinformatics‐based identification of hepatocellular carcinoma‐associated hub genes and assessment of the restorative effect of tannic acid in rat liver exposed to monosodium glutamate

A Study on the Awareness and Perceptions Regarding Monosodium Glutamate and its Potential Health Effects Amongst the Urban Population of Saudi Arabia

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