The interplay between neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, erectile dysfunction, and Peyronie’s disease: A meta-analysis of observational studies

Abstract

Introduction: This study aims to investigate the relationship between Neutrophil- Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR) with Erectile Dysfunction (ED) and Peyronie's disease (PD). Methods: We conducted a meta-analysis of the observational study by searching for the appropriate keywords in eight databases. The risk of publication bias of the included studies was assessed by Egger's test and Kendall's t. The data extraction was carried out for each study and analysed using Revman 5.0. Results: There were eleven eligible studies out of the 411 studies retrieved. Eight studies were conducted on cases of erectile dysfunction, and three studies on Peyronie's disease. There was a significant relationship between NLR, PLR and ED (SMD: 0.59, 95% CI: 0.33-0.85 and SMD: 0.64, 95% CI: 0.13-1.16, respectively). The same was also found for PD. The active phase of PD tended to have higher NLR (SMD: 0.68, 95% CI: 0.43-0.92) and PLR (SMD: 0.27, 95% CI: 0.06-0.49) compared to the chronic phase. No publication bias was found in both ED and PD studies. Conclusions: NLR and PLR indicate an ongoing inflammatory process in both ED and PD. These findings can be used as markers of treatment and prognosis of both diseases in sexual health care.

Association between polyunsaturated fatty acid intake and the prevalence of erectile dysfunction: A cross-sectional analysis of the NHANES 2001–2004

“…Previously published articles have demonstrated the role of inflammation and homocysteine in promoting ED [ 30 , 31 ]. Therefore, the following inflammatory biomarkers that may be associated with ED were selected in this study, such as white blood cell (WBC, 1000 cells/μl), lymphocytes (L, 1000 cells/μl); neutrophils (N, 1000 cells/μl), neutrophil-to-HDL cholesterol ratio (NHR), neutrophil-to-lymphocyte ratio (NLR), monocytes (M, 1000 cells/μl), monocyte-to-HDL cholesterol ratio (MHR), C-reactive protein (CRP, mg/l), CRP-to-lymphocyte ratio (CLR), CRP-to-albumin ratio (CAR) and alkaline phosphatase (ALP, U/l) [ 32 – 36 ].…”