“…Indeed, higher disease burden, biological dysfunction, depressive symptoms, and worsening cognition are related to higher neuroticism, and lower extraversion, openness, agreeableness and conscientiousness over time (Hakulinen et al, 2015; Jokela, Hakulinen, Singh-Manoux, & Kivimaki, 2014; Stephan, Sutin, Luchetti, & Terracciano, 2016; Wettstein et al, 2017). Worsening functional status, such as higher frailty over time is also related to maladaptive personality changes (Stephan, Sutin, Canada, & Terracciano, 2017).…”