The Interplay between the Effects of Lifetime Asthma, Smoking, and Atopy on Fixed Airflow Obstruction in Middle Age

Perret, Jennifer L; Dharmage, Shyamali C.; Matheson, Melanie C.; Johns, DP; Gurrin, Lyle C.; Burgess, John A.; Marrone, John; Markos, James; Morrison, Stephen; Feather, Iain; Thomas, Paul S.; McDonald, Christine F; Giles, Graham G.; Hopper, John L.; Wood‐Baker, Richard; Abramson, Michael J.; Walters, E. Haydn

doi:10.1164/rccm.201205-0788oc

Cited by 112 publications

(103 citation statements)

References 42 publications

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“…Perret and colleagues studied the interaction between current asthma, atopy and smoking in a group of middle-aged (40-44 years) subjects with fixed airflow obstruction [Perret et al 2013]. Fiftyseven percent of the cohort were ever smokers, with 9.5% having a smoking history of more than 30 pack years.…”

Section: Influence Of Smokingmentioning

confidence: 99%

Asthma and chronic obstructive pulmonary disease overlap: asthmatic chronic obstructive pulmonary disease or chronic obstructive asthma?

Slats

Taube

2015

Ther Adv Respir Dis

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Asthma and chronic obstructive pulmonary disease (COPD) are different disease entities. They are both clinical diagnoses, with diagnostic tools to discriminate between one another. However, especially in older patients (>55 years) it seems more difficult to differentiate between asthma and COPD. This has led to the definition of a new phenotype called asthma COPD overlap syndrome (ACOS). However, our understanding of ACOS is at a very preliminary stage, as most research has involved subjects with existing diagnoses of asthma or COPD from studies with different definitions for ACOS. This has led to different and sometimes opposing results between studies on several features of ACOS, also depending on the comparison with COPD alone, asthma alone or both, which are summarized in this review.We suggest not using the term ACOS for a patient with features of both asthma and COPD, but to describe a patient with chronic obstructive airway disease as completely as possible, with regard to characteristics that determine treatment response (e.g. eosinophilic inflammation) and prognosis (such as smoking status, exacerbation rate, fixed airflow limitation, hyperresponsiveness, comorbidities). This will provide a far more clinically relevant diagnosis, and would aid in research on treatment in more homogenous groups of patients with chronic airways obstruction. More research is certainly needed to develop more evidence-based definitions for this patient group and to evaluate biomarkers, which will help to further classify these patients, treat them more adequately and unravel the underlying pathophysiological mechanism.

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Section: Influence Of Smokingmentioning

confidence: 99%

Asthma and chronic obstructive pulmonary disease overlap: asthmatic chronic obstructive pulmonary disease or chronic obstructive asthma?

Slats

Taube

2015

Ther Adv Respir Dis

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“…Menezes and Hardin reported higher mean age in ACOS patients [12,13]. Increase of prevalence with aging is thought to be related to the development of persistent airway obstruction due to inadequate treatment or ongoing insults such as smoking [14,15]. A study by Kiljander et al revealed ACOS prevalence as 27.4% in asthma patients who have a history of smoking.…”

Section: Definition and Diagnosis Of Acosmentioning

confidence: 99%

Asthma COPD overlap syndrome (ACOS)

Kocakaya¹

2016

MMJ

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Asthma and chronic obstructive pulmonary disease (COPD) are the two most prevalent obstructive diseases of the lung. Although asthma and COPD differ in many ways some properties of each disease co-exist in some patients, particularly in patients with advanced age which recently brought up the term; Asthma-COPD Overlap Syndrome (ACOS). In addition to the fact that clinical trials deliberately exclude the patients in this group, the diagnostic criteria of ACOS are not well established. Both of these factors contribute to paucity of evidence based clinical information about ACOS. In this article my aim is to provide brief information about the history, description, clinical properties and treatment of this disease.

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“…Three studies were published in the Journal in 2013 that focused on airway remodeling in asthma (58-60). Perret and colleagues followed up a population-based cohort after 35 years and found that those with ongoing asthma had a significant and time-dependent relationship with lack of bronchodilator responsiveness (59). Furthermore, the effects of persistent asthma on fixed airway obstruction were synergistic with smoking, but only in those with atopy.…”

Section: Pathways That Affect Airway Remodeling and Cause Fixed Airflmentioning

confidence: 99%

Update in Asthma 2013

Cohn¹,

Woodruff²

2014

Am J Respir Crit Care Med

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The Interplay between the Effects of Lifetime Asthma, Smoking, and Atopy on Fixed Airflow Obstruction in Middle Age

Abstract: Active smoking and current clinical asthma both contribute substantially to fixed AO in middle age, especially among those with atopy. The interaction between these factors provides another compelling reason for atopic individuals with current asthma who smoke to quit.

Cited by 112 publications

References 42 publications

Asthma and chronic obstructive pulmonary disease overlap: asthmatic chronic obstructive pulmonary disease or chronic obstructive asthma?

Asthma and chronic obstructive pulmonary disease overlap: asthmatic chronic obstructive pulmonary disease or chronic obstructive asthma?

Asthma COPD overlap syndrome (ACOS)

Update in Asthma 2013

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