The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions

Gong, Xinru; Han, Zhoutong; Fan, Hongli; Wu, Yuqi; He, Yuanqiong; Fu, Yijie; Zhu, Tianmin; Li, Hui

doi:10.3389/fimmu.2023.1238673

Cited by 8 publications

(3 citation statements)

References 163 publications

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“…An increasing number of studies have also unveiled the nonconducting functions of potassium channels ( Forzisi and Sesti, 2022 ). On the one hand, they can modulate intracellular calcium concentration by influencing the membrane potential of nonexcitable cells leading to changes of calcium-dependent signaling pathways; on the other hand, they can directly activate signaling pathway proteins to regulate fundamental cell functions, such as proliferation, migration, apoptosis, and cytokine secretion ( Forzisi and Sesti, 2022 ; Gong et al, 2023 ).…”

Section: Molecular Composition Characteristics and Physiological Acti...mentioning

confidence: 99%

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The role of potassium ion channels in chronic sinusitis

Ding,

Gai,

et al. 2024

Front. Pharmacol.

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Chronic sinusitis is a common inflammatory disease of the nasal and sinus mucosa, leading to symptoms such as nasal congestion, runny nose, decreased sense of smell, and headache. It often recurs and seriously affects the quality of life of patients. However, its pathological and physiological mechanisms are not fully understood. In recent years, the role of potassium ion channels in the regulation of mucosal barrier function and inflammatory cell function has received increasing attention. In chronic sinusitis, there are often changes in the expression and function of potassium channels, leading to mucosal damage and a stronger inflammatory response. However, the related research is still in its early stages. This article will review the role of the potassium channel in the pathological and physiological changes of chronic sinusitis. The studies revealed that BK/TREK-1 potassium channel play a protective role in the nasal mucosal function through p38-MAPK pathway, and KCa3.1/Kv1.3 enhance the inflammatory response of Chronic rhinosinusitis by regulating immune cell function, intracellular Ca2+ signaling and ERK/MAPK/NF-κB pathway. Because ion channels are surface proteins of cell membranes, they are easier to intervene with drugs, and the results of these studies may provide new effective targets for the prevention and treatment of chronic sinusitis.

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Section: Molecular Composition Characteristics and Physiological Acti...mentioning

confidence: 99%

“…Nasal and sinus mucosal remodeling is an important pathophysiological basis for CRS, including epithelial cell damage, squamous metaplasia, and an increase in microvillus and goblet cells ( Gong et al, 2023 ; Xie et al, 2024 ), but the molecular mechanisms are not fully understood.…”

Section: The Role Of Potassium Ion Channels In Mucosal Remodeling Of ...mentioning

confidence: 99%

The role of potassium ion channels in chronic sinusitis

Ding,

Gai,

et al. 2024

Front. Pharmacol.

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“…Studies have shown that the incidence of olfactory dysfunction secondary to CRS is between 56% and 74%, with significant effects on the quality of life, including effects on diet, communication, and emotional wellbeing and loss of perception of dangerous odors, such as gases and toxic and harmful gases. However, the underlying mechanism remains elusive (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Association between peripheral eosinophilia, JESREC score, and olfactory dysfunction in patients with chronic rhinosinusitis

Zhang,

Li,

Wang

et al. 2024

Front. Immunol.

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ObjectiveThe purpose was to evaluate the relationship between peripheral eosinophilia, Japan Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) score, and olfactory dysfunction in chronic rhinosinusitis (CRS) patients and to explore the accuracy and specific cut points of the JESREC score in predicting olfactory dysfunction.MethodsIn this cross-sectional, retrospective study, olfactory function was assessed by the Sniffin’ Sticks 12-item test and multivariate logistic regression analyses were carried out. Receiver operating characteristic curves were plotted to derive accuracy and cutoff values for the JESREC scores of the olfactory dysfunction criterion.ResultsA total of 354 patients [mean (SD) age, 50.0 (14.9) years; 41.8% women] were included in the final analysis. The prevalence of olfactory dysfunction was 46.3%. Individuals who had olfactory dysfunction were more likely to be male (64.6% vs. 52.6%), have eosinophilic chronic rhinosinusitis (ECRS) (39.0% vs. 7.9%), have a longer course of CRS (2.3 years vs. 1.5 years), have higher JESREC scores (8.5 vs. 4.5), and have higher proportions of nasal polyps (78.7% vs. 18.9%) and peripheral eosinophilia (3.3% vs. 1.4%). In logistic analysis, the percentage of eosinophils (1.25, 1.13–1.37), JESREC score (1.31, 1.22–1.40), bilateral lesion (2.06, 1.25–3.41), nasal polyps (15.83, 9.23–27.16), CT shadow (2.73, 1.69–4.43), and ECRS (6.86, 3.68–12.80) were associated with olfactory dysfunction in CRS patients after controlling for covariates, while peripheral neutrophils were not significant. In addition, the area under the curve was 0.778 and the cutoff value for JESREC score for olfactory dysfunction was defined as 5.5.ConclusionsPeripheral eosinophilia and high JESREC scores were significantly associated with the risk of olfactory dysfunction in CRS patients, and special attention should be paid to patients with a JESREC score ≥6.

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Multiple cytokine analyses identify CSF1 as a robust biomarker for predicting postoperative recurrence in chronic rhinosinusitis with nasal polyps

Niu,

Cao,

et al. 2024

International Immunopharmacology

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The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions

Cited by 8 publications

References 163 publications

The role of potassium ion channels in chronic sinusitis

The role of potassium ion channels in chronic sinusitis

Association between peripheral eosinophilia, JESREC score, and olfactory dysfunction in patients with chronic rhinosinusitis

Multiple cytokine analyses identify CSF1 as a robust biomarker for predicting postoperative recurrence in chronic rhinosinusitis with nasal polyps

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