The Interpretive Art/Science of Pathology

Rv, Hutter

doi:10.3322/canjclin.28.3.141

CA: A Cancer Journal for Clinicians

1978

DOI: 10.3322/canjclin.28.3.141

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The Interpretive Art/Science of Pathology

Hutter Rv¹

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1985

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Interobserver reproducibility of histopathological features in stage II breast cancer

Kw¹,

Kalish

et al. 1985

Breast Cancer Res Tr

120

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Eleven surgical pathologists studied microscopic sections from 45 mastectomy specimens of node positive breast cancer patients who had been entered into ECOG clinical trials. Inter-observer reproducibility for histoprognostic features was examined as a prerequisite before a subsequent evaluation of their possible clinical applicability could be undertaken. Histological type, nuclear grade, tubular formation, and lymphoid reactions were studied in the cancerous tissues. Lymph nodal responses (follicular and pulp prominence, sinus histiocytosis) were also examined in a manner that stimulated slide review in routine surgical pathology practice. Numerous two-way comparisons of the pathologists' findings resulted in low levels of agreement (usually much less than 90%). The degree of inter-observer reliability is clinically unacceptable using customary slide review analysis. New ways of examining breast cancer tissues need to be explored in the search for prognostic features which can be applied to the clinical management of breast cancer patients.

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Interobserver reproducibility of histopathological features in stage II breast cancer

Kw¹,

Kalish

et al. 1985

Breast Cancer Res Tr

120

View full text Add to dashboard Cite

show abstract

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The Interpretive Art/Science of Pathology

Cited by 1 publication

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Interobserver reproducibility of histopathological features in stage II breast cancer

Interobserver reproducibility of histopathological features in stage II breast cancer

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