The Interrelated Effects of Dietary Cholesterol and Fat upon Human Serum Lipid Levels *

Connor, William E.; Stone, Daniel B.; Hodges, Robert E.

doi:10.1172/jci105044

Cited by 200 publications

(38 citation statements)

References 17 publications

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“…Cholesterol also did not correlate significantly with phospholipid in both the Bangkok and Muang Pol groups; and with the triglyceride and weight to height ratio for Muang Pol, Plasma cholesterol concentration depended directly on the dietary cholesterol (18) and also on the synthesis rate of the organism. In case there is no excess in fat intake and body weight is kept constant, plasma cholesterol con centrations do not vary considerably (19).…”

Section: Methodsmentioning

confidence: 74%

Serum lipid pattern in urban and rural thai population.

Pongpaew

Saovakontha

Schelp³

et al. 1978

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummarySerum cholesterol, triglyceride, phospholipid, total lipid and weight to height ratio were studied in 172 individuals from Bangkok, mainly university staff, and in 247 individuals from rural areas of northeast The lipid status in human blood is mainly investigated in western countries and there with respect to various forms of hyperlipidaemia. This is related to common diseases like coronary heart diseases, diabetes mellitus, hyperlipoproteinaemia and obesity (1). Publications dealing with the lipid status in epidemiological studies not directly related to risk of the above-mentioned diseases are rare and are also concentrated mainly to industrialized countries (2-4). There are almost no available data concerning the lipid status from developing countries. The present study was undertaken in order to start a collection of base line data for the lipid pattern in Thai populations and to correlate serum levels of cholesterol, triglyceride, phospholipid and total lipid to different socio-economic classes found in urban and rural populations. MATERIALS AND METHODSThe subjects who participated in this study were as follows: a total of 172 persons, 101 males and 71 females, mainly lecturers and staff members

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Section: Methodsmentioning

confidence: 74%

Serum lipid pattern in urban and rural thai population.

Pongpaew

Saovakontha

Schelp³

et al. 1978

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…31 ' 41 -M In one, a P/S ratio difference of 25-fold produced only an 8% decrease in plasma cholesterol levels, 41 and in another, no change in cholesterol levels was found with a 9-fold P/S ratio range. 50 Connor, et al 31 repeated the latter experiment using a 94-fold difference in P/S ratios and produced a 20% decrease in cholesterol levels. Thus, it appears that plasma cholesterol levels are less responsive to changes in the dietary P/S ratio when cholesterol is absent from the diet.…”

Section: Plasma Cholesterolmentioning

confidence: 99%

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

Goodnight¹,

Harris

Connor³

et al. 1982

Arteriosclerosis

654

150

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“…The concentration of total and LDL cholesterol in plasma is strongly influenced by the amount and type of lipid in the diet (13)(14)(15)(16). Thus, dietary triglycerides containing predominantly saturated fatty acids raise plasma LDL concentrations when compared with dietary triglycerides containing predominantly unsaturated fatty acids.…”

Section: Introductionmentioning

confidence: 99%

Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels.

Horton¹,

Cuthbert²,

Spady³

1993

J. Clin. Invest.

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The concentration of LDL in plasma is strongly influenced by the amount and the type of lipid in the diet. Recent studies in the hamster have shown that dietary fatty acids differentially affect circulating LDL levels primarily by altering receptor-dependent LDL uptake in the liver. To investigate the mechanistic basis of this effect, rates of receptor-dependent LDL transport in the liver were correlated with LDL receptor protein and mRNA levels in hamsters fed safflower oil or coconut oil and varying amounts of cholesterol. Hepatic LDL receptor activity was significantly lower in animals fed coconut oil than in animals fed safflower oil at all levels of cholesterol intake (26, 53, and 61% lower at cholesterol intakes of 0, 0.06, and 0.12%, respectively). These fatty acid-induced changes in hepatic LDL receptor activity were accompanied by parallel changes in hepatic LDL receptor protein and mRNA levels, suggesting that dietary fatty acids regulate the LDL receptor pathway largely at the mRNA level. (J. Clin. Invest. 1993.92:743-749.)

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The Interrelated Effects of Dietary Cholesterol and Fat upon Human Serum Lipid Levels *

Cited by 200 publications

References 17 publications

Serum lipid pattern in urban and rural thai population.

Serum lipid pattern in urban and rural thai population.

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels.

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