The interrelationship between clinical and immunity variables in epilepsy

Abstract

SUMMARYIntroduction. The role of cellular immunity in the pathogenesis of epilepsy, as an interaction between immunity and clinical and neurobiological variables is not properly understood. Aim. The aim of the current study was to investigate the possible relationship between epilepsy forms, gender, focus localization, lateralization, handedness and cellular immunity with seizures frequency, their severity and length of therapeutic remission in partial forms of epilepsy. Material and methods. Ninety two patients (38 men and 54 women) were included in the study. Symptomatic epilepsy was diagnosed in 40 patients and the cryptogenic form was diagnosed in 52 patients. The amount of different lymphocyte clusters were evaluated and they were transformed into nominal variables for MANOVA analysis. MANOVA was used for the analysis of the interrelationship between nominal fixed factors (epilepsy forms, gender, handedness, and focus laterality, and immunity variables) and dependent variables (remission and seizure frequency and their severity). Results. Simple partial seizure (SPS) and complex partial seizure (CPS) frequencies were under the influence of interaction between immune and neurobiological variables. SPS, and in particular sensory SPS, were associated with CD4/CD8 ratio, gender, left temporal focus and handedness. The highest frequencies of SPS were revealed in cases of low CD4/CD8 ratio combined with left temporal focus, female gender and left-handedness. The maximal CPS frequency was observed in patients with a left frontal focus combined with a high B-lymphocyte level. The more severe seizures were revealed in left-handers with low CD8 and high CD4/CD8 ratio and in frontal left focus and a high T-lymphocyte level. There was a correlation between CD4 cell level and length of remission.

The Role of Personal and Immune Variables in the Development of Co-Morbid Affective and Related Psychopathological Syndromes in Partial Epilepsies in Relation to Handedness

“…The certain role of immunity mechanisms in the pathogenesis of partial forms of epilepsy has been confirmed in our previous studies [18,19]. Thus, the combination of immunity variables with focus lateralization, gender and handedness had influence on the frequency of focal sensory seizures (FSS) in epilepsy.…”

“…Similarly, severe seizures were also observed in left-handers with frontal left focus and high T-lymphocyte level. The stochastically significant correlation between CD4 cell level and length of remission has been also observed [18].…”

The influence of clinical and immune variables on psychopathological syndromes in partial epilepsies in relation to handedness

“…The more severe seizures were revealed in left-handers with low CD8 and high CD4/CD8 ratio and in frontal left focus and high T-lymphocyte level. There was a correlation between CD4 cell level and length of remission (Kalinin et al, 2016).…”

“…In our previous studies the role of immunity mechanisms in the pathogenesis of partial forms of epilepsy has been reported (Kalinin et al, 2016;Kalinin et al, 2018). It concerned the influence of a combination of immunity variables with focus lateralization, gender and handedness on the frequency of focal sensory seizures (FSS) in epilepsy.…”