The Interrelationship Between Cryoablation, the Immune Response and the Tumor Microenvironment: Stimulatory and Suppressive Effects

Sabel, Michael S.

doi:10.1007/978-94-007-4694-7_5

Cited by 3 publications

(1 citation statement)

References 105 publications

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“…Following cryoablation and thermal ablation in mouse models, a significant amount of antigen-positive DCs and an increase of DC activation markers (e.g., CD80/86) within the draining lymph nodes have been demonstrated ( 113 , 129 , 130 ). Increased tumor-specific T cell activation in regional lymph nodes and expanded CD8 T cell populations have also been widely detected after focal ablation ( 131 ). Clinically, the changes in T cell population in the peripheral blood of patients with different tumor types following thermal ablation or cryoablation have been evaluated.…”

Section: Immunological Effects Of Focal Therapymentioning

confidence: 99%

Combining energy-based focal ablation and immune checkpoint inhibitors: preclinical research and clinical trials

2023

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Energy-based focal therapy (FT) uses targeted, minimally invasive procedures to destroy tumors while preserving normal tissue and function. There is strong emerging interest in understanding how systemic immunity against the tumor can occur with cancer immunotherapy, most notably immune checkpoint inhibitors (ICI). The motivation for combining FT and ICI in cancer management relies on the synergy between the two different therapies: FT complements ICI by reducing tumor burden, increasing objective response rate, and reducing side effects of ICI; ICI supplements FT by reducing local recurrence, controlling distal metastases, and providing long-term protection. This combinatorial strategy has shown promising results in preclinical study (since 2004) and the clinical trials (since 2011). Understanding the synergy calls for understanding the physics and biology behind the two different therapies with distinctive mechanisms of action. In this review, we introduce different types of energy-based FT by covering the biophysics of tissue-energy interaction and present the immunomodulatory properties of FT. We discuss the basis of cancer immunotherapy with the emphasis on ICI. We examine the approaches researchers have been using and the results from both preclinical models and clinical trials from our exhaustive literature research. Finally, the challenges of the combinatory strategy and opportunities of future research is discussed extensively.

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Section: Immunological Effects Of Focal Therapymentioning

confidence: 99%

Combining energy-based focal ablation and immune checkpoint inhibitors: preclinical research and clinical trials

2023

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Women’s Imaging in Global Health Radiology

Müllen

Harvey

Pollack

et al. 2019

Radiology in Global Health

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Activation of local and systemic anti-tumor immune responses by ablation of solid tumors with intratumoral electrochemical or alpha radiation treatments

Keisari

Hochman

Confino

et al. 2013

Cancer Immunol Immunother

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Cancer, the most devastating chronic disease affecting humankind, is treated primarily by surgery, chemotherapy, and radiation therapy. Surgery and radiotherapy are mainly used for debulking the primary tumor, while chemotherapy is the most efficient anti-metastatic treatment. To control better metastatic cancer, the host immune system should be stimulated. Yet, successful specific stimulation of the immune system against tumors was seldom achieved even in antigenic tumors. Our working hypothesis is that aggressive in situ tumor ablation can release tumor antigens and danger signals, which will enhance anti-tumor T cell responses resulting in the destruction of residual malignant cells in primary tumors and distant metastases. We developed two efficient in situ ablation treatments for solid cancer, which can be used to destroy the primary tumors and stimulate anti-tumor immune responses. The first treatment, electrochemical ablation, is applied through intratumoral electrodes, which deliver unipolar-pulsed electric currents. The second treatment, diffusing alpha-emitters radiation therapy (DaRT), is based on intratumoral (224)Ra-loaded wire(s) that release by recoil its daughter atoms. These short-lived alpha-emitting atoms spread in the tumor and spray it with lethal alpha particles. It was confirmed that these treatments effectively destroy various malignant animal and human primary solid tumors. As a consequence of such tumor ablation, tumor-derived antigenic material was released and provoked systemic T cell-dependent anti-tumor immunological reactions. These reactions conferred protection against a secondary tumor challenge and destroyed remaining malignant cells in the primary tumor as well as in distant metastases. Such anti-tumor immune responses could be further amplified by the immune adjuvant, CpG. Electrochemical ablation or DaRT together with chemotherapy and immunostimulatory agents can serve as treatment protocols for solid metastatic tumors and can be applied instead of or in combination with surgery.

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The Interrelationship Between Cryoablation, the Immune Response and the Tumor Microenvironment: Stimulatory and Suppressive Effects

Cited by 3 publications

References 105 publications

Combining energy-based focal ablation and immune checkpoint inhibitors: preclinical research and clinical trials

Combining energy-based focal ablation and immune checkpoint inhibitors: preclinical research and clinical trials

Women’s Imaging in Global Health Radiology

Activation of local and systemic anti-tumor immune responses by ablation of solid tumors with intratumoral electrochemical or alpha radiation treatments

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