The Interrelationship Between the Drug Embedded Tizr Surface Properties and Antibacterial Effect

VOICU, MANUELA ELENA

doi:10.31925/farmacia.2022.6.9

Cited by 3 publications

(6 citation statements)

References 37 publications

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“…The cumulative drug released fraction after 144 h was in the region of 90%. The result obtained is in agreement with those obtained for other nanostructures formed on the surface of the TiZr alloy, having drug embedded [ 23 , 24 ]. Generally speaking, the diffusion of active chemicals toward the solution may be impacted by the morphological characteristics of the films [ 44 ].…”

Section: Resultssupporting

confidence: 90%

“…aureus is, as can be seen, slightly lower than the value for E. coli. For the PPy-GS-coated TiZr alloy, the obtained values for the inhibition index are 75.4 for Staphylococcus aureus and 86.9 for Escherichia coli, being higher values than those For the PPy-GS-coated TiZr alloy, the obtained values for the inhibition index are 75.4 for Staphylococcus aureus and 86.9 for Escherichia coli, being higher values than those obtained for other nanostructures with embedded drugs [14,23]. Frequently better results are obtained for Staphylococcus aureus vs. E. coli, and this fact is attributed to differences in the membranes of the two organisms.…”

Section: Coating's Antibacterial Characteristicsmentioning

confidence: 67%

“…For the PPy–GS-coated TiZr alloy, the obtained values for the inhibition index are 75.4 for Staphylococcus aureus and 86.9 for Escherichia coli , being higher values than those obtained for other nanostructures with embedded drugs [ 14 , 23 ]. Frequently better results are obtained for Staphylococcus aureus vs. E. coli , and this fact is attributed to differences in the membranes of the two organisms.…”

Section: Resultsmentioning

confidence: 90%

“…More recently, smart drug delivery systems able to respond to various stimuli such as heat, pH, light, and magnetic and electric fields [ 20 , 21 ] have been investigated as well. Special attention has been paid to gentamicin as probably the most used antibiotic on coated implants presented in the literature [ 22 , 23 , 24 ]. The extensive use of gentamicin (GS) is probably due to its effect in inducing mesangial cell contraction and filtration reduction.…”

Section: Introductionmentioning

confidence: 99%

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Advanced Procedure of Simultaneous Electrodeposition from a Natural Deep Eutectic Solvent of a Drug and a Polymer Used to Improve TiZr Alloy Behavior

et al. 2023

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This paper presents research about the embedding and release of gentamicin from an electrochemical deposition of polypyrrole from ionic liquids such as choline chloride on TiZr bioalloy. The electrodeposited films were morphologically investigated using scanning electron microscopy (SEM) with an EDX module, and polypyrrole and gentamicin were both identified using structural FT-IR analysis. The film’s characterization was completed with an evaluation of hydrophilic–hydrophobic balance, with electrochemical stability measurements in PBS and with antibacterial inhibition. A decrease in the value of the contact angle was observed from 47.06° in the case of the uncoated sample to 8.63° in the case of the sample covered with PPy and GS. Additionally, an improvement in the anticorrosive properties of the coating was observed by increasing the efficiency to 87.23% in the case of TiZr–PPy–GS. A kinetic study of drug release was performed as well. The drug molecule might be provided by the PPy–GS coatings for up to 144 h. The highest amount released was calculated to be 90% of the entire drug reservoir capacity, demonstrating the effectiveness of the coatings. A non-Fickian behavior was established as a mechanism for the release profiles of the gentamicin from the polymer layer.

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Section: Resultssupporting

confidence: 90%

Section: Coating's Antibacterial Characteristicsmentioning

confidence: 67%

Section: Resultsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Advanced Procedure of Simultaneous Electrodeposition from a Natural Deep Eutectic Solvent of a Drug and a Polymer Used to Improve TiZr Alloy Behavior

et al. 2023

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“…Comparing this spectrum with the physical mixture without trehalose (PM1), we observed a peak of increased intensity at 3319 cm -1 , which was attributed to the stretching vibration of two crystalline water in trehalose dihydrate. The weaker peaks at around 2900 cm -1 corresponded to the C-H stretching in trehalose and poloxamer [39][40][41]. In the freeze-dried sample with trehalose, the peaks discussed so far have disappeared and an intense broad peak appeared in the 3700 -3000 cm -1 wavenumber range strongly suggesting the formation of hydrogen bonds.…”

Section: Structural Characterizationmentioning

confidence: 92%

Preparation and Characterization of Smartcrystals for Dissolution Enhancement of Poorly Water – Soluble Niflumic Acid

Alshweiat¹

2023

FARMACIA

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Nanonization is commonly applied to overcome the challenge of low solubility and dissolution improving the bioavailability of poorly water-soluble drugs. In this study, nanocrystals of niflumic acid (NIF) were produced by bead pre-milling followed by high-pressure homogenization (HPH) to enhance the dissolution rate of NIF. Different drying procedures were applied to elucidate the effect of drying processes on the re-dispersibility of drug nanocrystals, including drying at room temperature, vacuum drying, and freeze-drying using mannitol or trehalose as a cryoprotectant. NIF nanosuspensions were checked for the mean particle size (MPS), polydispersity index (PDI), and zeta potential (ZP). The dry nanocrystals were characterized by their MPS, thermal and structural manner, solubility, and dissolution. After 40 min of pre-milling and 30 min of HPH, NIF nanosuspension showed MPS and PDI of 240 nm and 0.29, respectively. The drying procedure showed a significant impact on the MPS after re-dispersion in water. Simple drying and vacuum drying produced nanocrystals of 813.5 and 560.6 nm, respectively. However, mannitol and trehalose-based dried nanocrystals showed MPS of 406.55 and 276.55 nm, respectively. DSC thermograms and XRPD diffractograms confirmed the crystallinity of NIF. The smartcrystals showed a complete NIF release from the freeze-dried particles with trehalose at pH 7.4, whereas, at pH 5.6, a maximum of 20% of drug release was obtained from the freeze-dried particle with mannitol. The raw NIF showed less than 5% release in the both media. The enhancement of the dissolution rate of NIF would increase its onset of action, reduce the required dose, and minimize its gastrointestinal side effects, resulting in an efficient delivery system. RezumatNanonizarea este o metodă aplicată frecvent pentru a depăși provocările legate de solubilitate și dizolvare redusă, îmbunătățind biodisponibilitatea medicamentelor puțin solubile în apă. În acest studiu, nanocristalele de acid niflumic (NIF) au fost produse prin pre-măcinarea particulelor, urmată de omogenizare la presiune înaltă (HPH) pentru a crește viteza dizolvării. Au fost aplicate diferite proceduri de uscare pentru a elucida efectul procesului de uscare asupra redispersabilității nanocristalelor de substanță medicamentoasă, incluzând uscare simplă la temperatura camerei, uscare în vid și uscare prin liofilizare folosind manitol sau trehaloză ca crioprotector. Nanosuspensiile NIF au fost analizate din punct de vedere al mărimii medii a particulei (MPS), indicele de polidispersie (PDI) și potențialului zeta (ZP). Nanocristalele uscate au fost caracterizate privind mărimea particulelor, comportamentul termic, structural, solubilitatea și dizolvarea. După 40 de minute de pre-măcinare și 30 de minute de HPH, nanosuspensia NIF a prezentat MPS de 240 nm și, respectiv PDI de 0,29. Procedura de uscare a arătat un impact semnificativ asupra MPS după redispersare în apă. Uscarea simplă și uscarea în vid au produs nanocristale de 813,5 și, respectiv, 560,6 nm. Totuși, nanoc...

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Characterization of Two Types of Polylactic Acid Coating Loaded with Gentamicin Sulphate Deposed on AZ31 Alloy

et al. 2023

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This paper compares two types of polylactic acid (PLA) coating on AZ31 alloy obtained by dip coating and electrospinning. Both types of coating were loaded with gentamicin sulphate (GS) and the drug-loading efficiency and release were assessed. A higher encapsulation and release efficiency of GS was seen for dip coating (73% and 49.53%, respectively) compared to nanofiber coating (65% and 12.37%, respectively). Furthermore, the antibacterial effect of the samples with and without GS was assessed using Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria, showing that the samples with the drug encapsulated are more resistant to bacteria than the other samples. The electrochemical data reveal a higher stability in the SBF of the surface obtained by dipping than that obtained by electrospinning. The PLA coating shows a porosity of 46% for the sample obtained through dip coating and 32% for nanofibers, which is in accordance with the BET analysis results. Moreover, a higher adhesion strength was obtained for AZ31-PLA-dip (4.99 MPa) than for the AZ31-PLA-nanofibers (1.66 MPa). All samples were structurally, morphologically, and topographically characterized.

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The Interrelationship Between the Drug Embedded Tizr Surface Properties and Antibacterial Effect

Cited by 3 publications

References 37 publications

Advanced Procedure of Simultaneous Electrodeposition from a Natural Deep Eutectic Solvent of a Drug and a Polymer Used to Improve TiZr Alloy Behavior

Advanced Procedure of Simultaneous Electrodeposition from a Natural Deep Eutectic Solvent of a Drug and a Polymer Used to Improve TiZr Alloy Behavior

Preparation and Characterization of Smartcrystals for Dissolution Enhancement of Poorly Water – Soluble Niflumic Acid

Characterization of Two Types of Polylactic Acid Coating Loaded with Gentamicin Sulphate Deposed on AZ31 Alloy

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