The Interrelationships Among Sex Hormone Concentrations, Motoneuron Excitability, and Anterior Tibial Displacement in Women and Men

Hoffman, Mark A.; Harter, Rod A.; Hayes, Bradley T.; Wojtys, Edward M.; Murtaugh, Paul A.

doi:10.4085/1062-6050-43.4.364

Cited by 32 publications

(35 citation statements)

References 47 publications

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“…Nineteen females and thirteen males between the ages of 18 and 35 participated in the study. To be eligible for participation, female participants were required to report having regular menstrual cycles, as defined by a cycle length between 28 and 32 days that varied no more than 3 days, over the previous 3 cycles . Additionally, the female participants were required to report not taking any hormone‐based contraceptives within the year prior to participation in the study.…”

Section: Methodsmentioning

confidence: 99%

“…Prior to the collection of the H‐reflexes, the electrode sites on the soleus, tibialis anterior, and lateral malleolus were prepped for application of lubricated surface electromyography (EMG) electrodes (Ag/AgCl). The EMG electrodes on the soleus and the tibialis anterior were placed over the muscles longitudinally with an interelectrode distance of 2 cm . The EMG of the evoked responses was sampled at 2000 Hz .…”

Section: Methodsmentioning

confidence: 99%

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Presynaptic inhibition decreases when estrogen level rises

Hoffman

Doeringer

Norcross

et al. 2018

Scandinavian Med Sci Sports

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The objective was to determine estrogen's influence on control of a skeletal muscle through measurements of motorneuron excitability (H:M ratio) and presynaptic inhibition (PI). Estrogen serum concentrations were measured at menses and ovulation of female subjects and compared to male controls. Data were analyzed from 12 women and 13 men reporting no history of knee ligament injury. Women reported regular menstrual cycles and no hormone-based contraceptive use for the previous year. Women were tested at menses (Time1) and ovulation (Time2). Men were tested twice, approximately 14 days apart. Analysis indicated no difference in the H:M ratio between the sexes at either time point. A significant difference for the sexes was detected in the magnitude of estrogen change (∆EST) between observations. At Time1, the male and female estrogen concentrations were not different; however, they were different at Time2, primarily due to the large rise observed in the women. A significant difference between the sexes was also seen in the magnitude of change for PI (∆PI) between observations. As with EST, the levels of PI between the sexes at Time1 were not different; however, a difference existed at Time 2. Estrogen interacts with GABA at several nervous system locations affecting inhibition of synaptic transmission. This is the first study to investigate changes in PI of a skeletal muscle between times of low and high estrogen. Improving the understanding of estrogen's influence on skeletal muscles may provide answers to why noncontact anterior cruciate ligament injuries of the knee occur more frequently in women.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Presynaptic inhibition decreases when estrogen level rises

Hoffman

Doeringer

Norcross

et al. 2018

Scandinavian Med Sci Sports

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“…It is apparent that menstrual cycle sex hormones profoundly affect excitability of the central nervous system. Using H-reflexes as a metric for excitability at the spinal level, Hoffman et al (15) demonstrated that there was no change across the menstrual cycle. This indicates that changes in central nervous system excitability likely occur at the cortical and/or subcortical levels.…”

Section: Applied Sciencesmentioning

confidence: 99%

Menstrual Cycle Mediates Vastus Medialis and Vastus Medialis Oblique Muscle Activity

Tenan

Peng

Hackney

et al. 2013

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Other inclusion criteria were a positive Zohler (Appendix 1) or Clarke sign (Appendix 2), patellar tenderness, and an average pain level in the preceding month of at least 3 on a visual analog scale (VAS) . Additional inclusion criteria were insidious onset of symptoms (nontraumatic), a score of at least 11 on the Persian version of the Functional Index Questionnaire (FIQ), age ≤ 40 years (to reduce the likelihood of osteoarthritic changes), unilateral PFPS, body mass index between 18.5 and 24.9 kg/m 2 , normal menstrual cycle, that is, a self‐reported cycle duration of 22‐36 days with no more than 3 days of variation in cycle length during the previous 3 months, and not using oral contraceptive hormones for 3 months before the start of the study.…”

Section: Methodsmentioning

confidence: 99%

Changes in Knee Vastii Muscle Activity in Women with Patellofemoral Pain Syndrome During the Menstrual Cycle

Samani

Yoosefinejad

Campos

et al. 2020

PM&R

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Background Changes in hormonal levels during the menstrual cycle are known to affect muscle electromyographic (EMG) activity, but no studies have investigated the effect of hormonal changes on the EMG activity of muscles around the knee in patients with patellofemoral pain syndrome (PFPS). Objective To evaluate the EMG activity of the vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles during toe rise and heel rock tasks in different phases of the menstrual cycle in women with PFPS. Design Cross sectional study. Setting Rehabilitation Research Center at the School of Rehabilitation Sciences of Shiraz University of Medical Sciences. Participants Ten women with PFPS between 18 and 40 years of age. Intervention Not applicable. Main Outcome Measures The VL/VMO amplitude ratio and differences between onset (onset VL−onset VMO) of vastii muscle activity were measured in the affected limb during rise and rock tasks in the follicular and ovulatory phases of the menstrual cycle. The signals were analyzed with MATLAB software. Results During both tasks, there were no significant changes in onset differences in vastii muscles between the ovulatory and follicular phases. However, the amplitude ratio (VL/VMO) was significantly lower in the ovulatory phase compared to the follicular phase (P = .035 for rise tasks and .010 for rock tasks). Conclusion The menstrual cycle may affect some EMG parameters. These factors can be taken into account when planning sports and rehabilitation training programs.

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The Interrelationships Among Sex Hormone Concentrations, Motoneuron Excitability, and Anterior Tibial Displacement in Women and Men

Cited by 32 publications

References 47 publications

Presynaptic inhibition decreases when estrogen level rises

Presynaptic inhibition decreases when estrogen level rises

Menstrual Cycle Mediates Vastus Medialis and Vastus Medialis Oblique Muscle Activity

Changes in Knee Vastii Muscle Activity in Women with Patellofemoral Pain Syndrome During the Menstrual Cycle

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