The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia

DeBaun, Michael R.; Strunk, Robert C.

doi:10.1016/s0140-6736(16)00145-8

Cited by 61 publications

(54 citation statements)

References 61 publications

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“…73,74,76 There is good evidence that asthma is exacerbated by air pollutants, particularly ozone, 77 and there is a strong association between asthma and acute complications of sickle cell disease. 78 The analysis and interpretation of climatic and air-quality effects are complicated by the close correlations among the various factors and the lack of consistency in methodologic and statistical approaches. Furthermore, all studies so far have looked at associations at the population level.…”

mentioning

confidence: 99%

Sickle Cell Disease

2017

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mentioning

confidence: 99%

Sickle Cell Disease

2017

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“…Our definition of asthma may have underestimated the number of children who actually had asthma because our definition required both a physician diagnosis of asthma and a prescription of asthma medication. A more liberal diagnosis of asthma, commonly used in large epidemiological studies, is a physician only diagnosis of asthma (von Mutius et al , ; Subramanian & Kennedy, ; DeBaun & Strunk, ).…”

Section: Discussionmentioning

confidence: 99%

Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia

Willen

Rodeghier²,

Strunk

et al. 2018

Br J Haematol

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Asthma is associated with higher rates of acute chest syndrome (ACS) and vaso-occlusive pain episodes among children with sickle cell anaemia (SCA). Aeroallergen sensitization is a risk factor for asthma. We hypothesized that aeroallergen sensitization is associated with an increased incidence of hospitalizations for ACS and pain. Participants in a multicentre, longitudinal cohort study, aged 4-18 years with SCA, underwent skin prick testing to ten aeroallergens. ACS and pain episodes were collected from birth until the end of the follow-up period. The number of positive skin tests were tested for associations with prospective rates of ACS and pain. Multivariable models demonstrated additive effects of having positive skin tests on future rates of ACS (incidence rate ratio (IRR) for each positive test 1·23, 95% confidence interval [CI] 1·11-1·36, P < 0·001). Aeroallergen sensitization was not associated with future pain (IRR 1·14, 95%CI 0·97-1·33, P = 0·11). Our study demonstrated that children with SCA and aeroallergen sensitization are at increased risk for future ACS. Future research is needed to determine whether identification of specific sensitizations and allergen avoidance and treatment reduce the risk of ACS for children with SCA.

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“…Since inflammation has an important role in the pathogenesis of vaso-occlusion and asthma augments the pro-inflammatory state, a vicious cycle of inflammation, asthma and vaso-occlusion develops in SCA (27). Asthma among children and adults with SCA is associated with increased incidence of SCA-related morbidity and mortality (27, 28). Studies show elevated levels of leukotrienes in plasma in SCA individuals, which correlates with increased vaso-occlusion and acute chest syndrome (ACS) (29, 30).…”

Section: Sickle Cell Anemiamentioning

confidence: 99%

Placenta growth factor mediated gene regulation in sickle cell disease

2018

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Sickle cell anemia (SCA) is an autosomal recessive disorder caused by mutation in the β-globin gene. Pulmonary hypertension (PH), a complication of SCA, results in severe morbidity and mortality. PH is a multifactorial disease: systemic vasculopathy, pulmonary vasoconstriction, and endothelial dysfunction and remodeling. Placenta growth factor (PlGF), an angiogenic growth factor, elaborated from erythroid cells, has been shown to contribute to inflammation, pulmonary vasoconstriction and airway hyper-responsiveness (AH) in mouse models of sickle cell disease. In this review, we summarize the cell-signaling mechanism(s) by which PlGF regulates the expression of genes involved in inflammation, PH and AH in cell culture and corroborate these findings in mouse models of SCA and in individuals with SCA. The role of microRNAs (miRNAs) in the post-transcriptional regulation of these genes is presented and how these miRNAs located in their host genes are transcriptionally regulated. An understanding of the transcriptional regulation of these miRNAs provides a new therapeutic approach to ameliorate the clinical manifestations of SCA.

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The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia

Cited by 61 publications

References 61 publications

Sickle Cell Disease

Sickle Cell Disease

Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia

Placenta growth factor mediated gene regulation in sickle cell disease

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