The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care

Koons, Brittany; Anderson, Michaela R.; Smith, Patrick J.; Greenland, John R.; Singer, Jonathan P.

doi:10.1007/s40472-022-00365-2

Cited by 6 publications

(1 citation statement)

References 138 publications

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“…This is associated with adverse outcomes such as delayed graft function, poorer tolerance to immunosuppression, (prolonged duration of) hospitalization, graft loss, and mortality [ 12 , 25 – 30 ]. The prevalence of frailty in lung transplant patients ranges from 10 to 70% and leads to a higher risk of mortality, prolonged hospitalization, rehospitalization, and a decrease in health-related quality of life [ 17 , 31 – 35 ]. In the liver transplant population, 25% of transplant patients are considered frail which is associated with an increased mortality rate, number of hospitalizations and length of stay in the hospital [ 36 – 39 ].…”

Section: The Impact Of Biological Aging On Transplant Outcomesmentioning

confidence: 99%

Prehabilitation in Adult Solid Organ Transplant Candidates

et al. 2023

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Purpose of Review To highlight the importance of biological age in the context of prehabilitation and to present relevant research regarding prehabilitation prior to solid organ transplantation. Recent Findings Studies on the effect of prehabilitation have been performed in kidney-, lung-, liver-, and heart transplant patient populations. Prior to kidney transplantation, exercise interventions have been shown to improve cardiopulmonary- and physical fitness and result in a decreased length of hospital stay postoperatively. Among lung transplant candidates, various methods of prehabilitation have been studied including home-based, outpatient and in-patient programs, consisting of physical training, psychological support, education, and nutritional interventions. Overall, prehabilitation seems to improve or maintain quality of life and exercise capacity in this patient population. Patients undergoing liver transplantation seem to benefit from prehabilitation as well. Not only does it seem safe and feasible, but significant improvements in aerobic and functional capacity have also been found. Regarding heart transplant candidates, both inpatient and outpatient, supervised prehabilitation programs show promising results with improvements in exercise capacities and quality of life. Summary Prehabilitation is an effective and safe intervention for improving functional outcomes of solid organ transplant patients. Future studies should evaluate whether prehabilitation translates into improved pre- and post-transplant clinical outcomes.

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Section: The Impact Of Biological Aging On Transplant Outcomesmentioning

confidence: 99%

Prehabilitation in Adult Solid Organ Transplant Candidates

et al. 2023

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Evaluation of Candidates for Lung Transplant—A Review of Patient-Specific Risk Factors

Leard

2024

Curr Pulmonol Rep

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Purpose of review The purpose of this paper is to review the evaluation of patients who are potential candidates for a lung transplant. Attention is paid to patient-specific risk factors considered when determining if an individual is a candidate for a lung transplant. Recent findings Recent consensus statements and a review of the literature support the notion that patient-specific risk factors associated with adverse outcomes following lung transplant should be identified and used to determine whether an individual patient is a candidate for lung transplant. The rationale for considering these risk factors is discussed. Early referral is encouraged to enable individuals time to reduce risk when modifiable risk factors are identified. Summary Patient-specific risk factors for adverse post-lung transplant outcomes should be identified and modified, if possible, to reduce risk. Additional research is required to better understand which ones place the recipient at the greatest risk and to guide the calculation of acceptable risk. Interprofessional teams at each lung transplant center must consider the combination of patient-specific risk factors in a risk-benefit analysis to make the determination as to whether the candidate will be listed for a lung transplant. These determinations should be transparent, equitable, and communicated clearly.

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