Abstract.We report the first results of our ongoing campaign to discover the first brown dwarfs (BD) in NGC 2264, a young (3 Myr), populous star forming region for which our optical studies have revealed a very high density of potential candidates -236 in <1 deg 2 -from the substellar limit down to at least ∼20 M Jup for zero reddening. Candidate BD were first selected using wide field (I, z) band imaging with CFH12K, by reference to current theoretical isochrones. Subsequently, 79 (33%) of the I, z sample were found to have near-infrared 2MASS photometry (JHK s ± 0.3 mag or better), yielding dereddened magnitudes and allowing further investigation by comparison with the location of NextGen and DUSTY isochrones in colourcolour and colour-magnitude diagrams involving various combinations of I, J, H and K s . We discuss the status and potential substellarity of a number of relatively unreddened (A v < ∼ 5) likely low-mass members in our sample, but in spite of the depth of our observations in I, z, we are as yet unable to unambiguously identify substellar candidates using only 2MASS data. Nevertheless, there are excellent arguments for considering two faint (observed I ∼ 18.4 and 21.2) objects as cluster candidates with masses respectively at or rather below the hydrogen burning limit. More current candidates could be proven to be cluster members with masses around 0.1 M via gravity-sensitive spectroscopy, and deeper near-infrared imaging will surely reveal a hitherto unknown population of young brown dwarfs in this region, accessible to the next generation of deep near-infrared surveys.