The interval transfer of a frozen‐thawed embryo is more successful than a fresh embryo transfer for women undergoing IVF with recurrent implantation failure after cleavage stage embryo biopsy

Pontré, Jennifer; Ryan, John P.; Tan, A.S.C.; Hart, Roger

doi:10.1111/ajo.12798

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…Pregnancy rates after re-implantation of ovarian tissue are similar between slow freezing and fast freezing (vitrification) methods; however, vitrified transplants have longer duration of function [19] (Figure 2). Pregnancy and live birth rate after frozen embryo transfer are either equivalent or higher than those achieved after fresh embryo transfer [20]. The embryos have been successfully frozen at different stages of development (Figure 3).…”

Section: Fertility Preservation Options For Womenmentioning

confidence: 96%

“…Therefore, in such procedures, enough sperm should be collected via ejaculation or testicular tissue and preserved for future use before initiating hormonal or surgical interventions [20]. Similarly, injury to the spinal cord, surgery of the retroperitoneal lymph node, aortic-iliac reconstruction and colorectal incisions may cause anejaculation.…”

Section: Medical Conditionsmentioning

confidence: 99%

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Fertility Preservation Indications and Available Options for Adult Non-Cancer Individuals

Javed¹

2019

BJSTR

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Fertility preservation has been traditionally recommended for cancer and infertile patients. However, it is now increasingly utilized by healthy men and women due to personal preferences or demands of the society. For women, oocyte and embryo cryopreservation is highly successful. Ovarian tissue cryopreservation and re-implantation, though successfully utilized, is still experimental. For men, sperm retrieved from ejaculate or surgical intervention of epididymis and testes have long been successfully cryopreserved. Outcome of fresh or cryopreserved sperm are similar. Indication of fertility preservation varies depending on medical or genetic condition, personal preference, career requirement or apprehensible risk of damage to gametes. This mini-review highlights multiple indications and available options for fertility preservation in non-cancer adult men and women.

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Section: Fertility Preservation Options For Womenmentioning

confidence: 96%

Section: Medical Conditionsmentioning

confidence: 99%

Fertility Preservation Indications and Available Options for Adult Non-Cancer Individuals

Javed¹

2019

BJSTR

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“…It is of great significance to analyze the related influencing factors of pregnancy failure in ART for clinical prevention and treatment. Many studies only analyzed risk factors for pregnancy failure after fresh or frozen cycles, [13][14][15] whereas taking pregnancy failure for the whole ART into consideration is essential for a more appropriate evaluation. Based on this, this study selected infertility patients who underwent ART in our hospital in the past 6 years as the research objects to study the related influencing factors (patients' baseline and treatment characteristics) of pregnancy failure.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Pregnancy Failure in Infertile Patients Undergoing Assisted Reproductive Technology

Yang

Tang

et al. 2022

IJGM

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Background Infertile couples need to use assisted reproductive technology (ART) to give birth. However, pregnancy failure after ART is not uncommon. At present, the results of studies on the causes of pregnancy failure after ART are inconsistent. Methods A retrospective cohort study involving 715 embryo transfer cycles was conducted at the Reproductive Medicine Center of Meizhou People’s Hospital, from December 2015 to June 2022. According to the pregnancy, they were divided into clinical pregnancy group and pregnancy failure group. The relationship between demographic characteristics and pregnancy status between the two groups was analyzed. Results The pregnancy failure rate after ART was 49.7% (355/715). There were statistically significant distribution differences of maternal age, paternal age, COH protocols, and number of embryos transferred between clinical pregnancy and pregnancy failure groups (all P<0.01). Multiple logistic regression analysis shows that high maternal age (>35 years old vs ≤35 years old: OR 2.173, 95% CI: 1.386–3.407, P=0.001), and GnRH-a short protocol (GnRH-a short protocol vs GnRH-a long protocol: OR 2.139, 95% CI: 1.127–4.058, P=0.020) may increase risk of pregnancy failure in ART pregnancies, while two embryos transferred (two embryos transferred vs one embryo transferred: OR 0.563, 95% CI: 0.377–0.839, P=0.005) may reduce risk of pregnancy failure. In addition, high maternal age, GnRH antagonist protocol, and GnRH-a short protocol may increase risk of implantation failure, while two embryos transferred may reduce risk of implantation failure. And high maternal age may increase risk of biochemical pregnancy. Conclusion The risk of pregnancy failure increased in ART cycles with maternal age >35 years old and GnRH-a short protocol, while reduced with two embryos transferred.

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“…FET nearly eliminates the risk of ovarian hyperstimulation syndrome [14][15][16][17][18][19]. Additionally, FET demonstrates equivalent or higher implantation and ongoing pregnancy rates compared to fresh embryo transfer, hypothesized to result from improved embryo-endometrium synchrony and more physiological estradiol levels [13,[20][21][22][23][24][25][26]. Most importantly, perinatal outcomes including low birth weight, preterm delivery, and pre-eclampsia favor FET over fresh embryo transfer [26][27][28][29][30][31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Pregnancy rates after pre-implantation genetic screening for aneuploidy are only superior when trophectoderm biopsy is performed on hatching embryos

Singh

Hobeika

Knochenhauer

et al. 2019

J Assist Reprod Genet

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Purpose In vitro fertilization with trophectoderm embryo biopsy and pre-implantation genetic screening with comprehensive chromosomal screening (PGS-CCS) for aneuploidy is becoming increasingly more popular. Embryos are cryopreserved and implanted in a subsequent frozen thawed embryo transfer cycle (FET). No studies have investigated differences in pregnancy outcomes by timing of trophectoderm biopsy relative to stages of blastocyst development. Methods Retrospective study of all patients (n = 363) at a single IVF center between January 1, 2013 and December 31, 2016 undergoing single embryo transfer with PGS-CCS where embryos were cryopreserved with subsequent FET. Embryo expansion and grading was assessed both at the time of biopsy and transfer. Pregnancy rates were analyzed by embryo expansion and embryo grading. Results Implantation, clinical pregnancy, and live birth rates improved significantly with increased embryo expansion at the time of embryo biopsy (P < 0.001). Pregnancy loss decreased with increases in embryo expansion prior to biopsy (P < 0.001). Superior live birth rates with PGS-CCS were seen when embryos were hatching at the time of biopsy (p < 0.001). For fresh and frozen embryo transfers without PGS-CCS, embryo expansion did not affect pregnancy outcomes. Conclusions PGS-CCS significantly increases implantation and live birth rates only if embryos are hatching at the time of biopsy. The embryo biopsy itself on a non-hatching embryo significantly damages the embryo in ways which are not reflected in future embryo expansion. IVF labs should wait until embryos hatch before performing trophectoderm biopsy.

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The interval transfer of a frozen‐thawed embryo is more successful than a fresh embryo transfer for women undergoing IVF with recurrent implantation failure after cleavage stage embryo biopsy

Abstract: After cleavage stage biopsy, frozen ET was more successful than fresh ET. Chance of conception and serum βhCG concentration correlated with number of cells present at time of biopsy.

Cited by 6 publications

References 31 publications

Fertility Preservation Indications and Available Options for Adult Non-Cancer Individuals

Fertility Preservation Indications and Available Options for Adult Non-Cancer Individuals

Risk Factors of Pregnancy Failure in Infertile Patients Undergoing Assisted Reproductive Technology

Pregnancy rates after pre-implantation genetic screening for aneuploidy are only superior when trophectoderm biopsy is performed on hatching embryos

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