The intestinal microbiome and surgical disease

Krezalek, Monika A.; Skowron, Kinga B.; Guyton, Kristina; Shakhsheer, Baddr A.; Hyoju, Sanjiv; Alverdy, John C.

doi:10.1067/j.cpsurg.2016.06.001

Cited by 25 publications

(18 citation statements)

References 360 publications

(399 reference statements)

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“…The identification of this vast community of microbiota quickly led to demonstration of the consequences of intestinal microbiota in diseases once thought to be far removed and distinct from the gut, such as hypertension and Parkinson's Disease . But as interactions between distant systems are increasingly uncovered, interest in the relevance of gut microbiota closer to home, within the GIT itself, has also had a revival with excellent reviews published suggesting an important role for microbiota in wound healing in surgery and also in GIT cancers . Intestinal antisepsis is not a new concept in GIT surgery particularly in the lower GIT which harbours the highest concentration of bacteria within the human body under conditions of health.…”

Section: The Role Of the Intestinal Microbiomementioning

confidence: 99%

The triune of intestinal microbiome, genetics and inflammatory status and its impact on the healing of lower gastrointestinal anastomoses

2017

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Gastrointestinal resections are a common operation and most involve an anastomosis to rejoin the ends of the remaining bowel to restore gastrointestinal (GIT) continuity. While most joins heal uneventfully, in up to 26% of patients healing fails and an anastomotic leak (AL) develops. Despite advances in surgical technology and techniques, the rate of anastomotic leaks has not decreased over the last few decades raising the possibility that perhaps we do not yet fully understand the phenomenon of AL and are thus ill‐equipped to prevent it. As in all complex conditions, it is necessary to isolate each different aspect of disease for interrogation of its specific role, but, as we hope to demonstrate in this article, it is a dangerous oversimplification to consider any single aspect as the full answer to the problem. Instead, consideration of important individual observations in parallel could illuminate the way forward towards a possibly simple solution amidst the complexity. This article details three aspects that we believe intertwine, and therefore should be considered together in wound healing within the GIT during postsurgical recovery: the microbiome, the host genetic make‐up and their relationship to the perioperative inflammatory status. Each of these, alone or in combination, has been linked with various states of health and disease, and in combining these three aspects in the case of postoperative recovery from bowel resection, we may be nearer an answer to preventing anastomotic leaks than might have been thought just a few years ago.

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Section: The Role Of the Intestinal Microbiomementioning

confidence: 99%

The triune of intestinal microbiome, genetics and inflammatory status and its impact on the healing of lower gastrointestinal anastomoses

2017

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“…Besides antibiotics, several other factors inherent to ICU stay are associated with a disturbance in the host's microbiota, also called "dysbiosis, " where the balance between potentially pathogenic and beneficial bacteria is aberrant (Kitsios et al, 2017). These factors include a change in nutrition, non-antibiotic pharmacological interventions (e.g., proton pump inhibitors and vasopressors), and various invasive procedures including endotracheal intubation and surgery (Krezalek et al, 2016;Kitsios et al, 2017). Beneficial roles of the healthy gut microbiota on human physiology are complex and include nutrient metabolism, modulation of host immune responses (Sekirov et al, 2010) and protection against potential pathogens by competition (Harris et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Marked Changes in Gut Microbiota in Cardio-Surgical Intensive Care Patients: A Longitudinal Cohort Study

Aardema

Lisotto

Kurilshikov

et al. 2020

Front. Cell. Infect. Microbiol.

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“…Conocer y modular la microbiota intestinal puede ayudar a reducir riesgos y contribuir a alterar el curso clínico de algunas enfermedades (6) .…”

Section: Introductionunclassified

Microbiota en el paciente quirúrgico del aparato digestivo: diagnóstico y manejo

Waitzberg¹

2020

Rev. Nutr. Clin. Metab.

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The intestinal microbiome and surgical disease

Cited by 25 publications

References 360 publications

The triune of intestinal microbiome, genetics and inflammatory status and its impact on the healing of lower gastrointestinal anastomoses

The triune of intestinal microbiome, genetics and inflammatory status and its impact on the healing of lower gastrointestinal anastomoses

Marked Changes in Gut Microbiota in Cardio-Surgical Intensive Care Patients: A Longitudinal Cohort Study

Microbiota en el paciente quirúrgico del aparato digestivo: diagnóstico y manejo

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