The intestinal microbiota as a therapeutic target in the treatment of NAFLD and ALD

Huang, Weifang; Kong, Desong

doi:10.1016/j.biopha.2021.111235

Cited by 21 publications

(18 citation statements)

References 172 publications

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“…NAFLD is the leading chronic liver disease worldwide with an estimated global prevalence of 25%. In approximately 10-20% of cases, this can lead to NASH [16]. This subgroup has an increased risk for disease progression, including the development of liver cirrhosis, hepatocellular carcinoma, and/or the need for liver transplantation.…”

Section: Discussionmentioning

confidence: 99%

“…After entering the portal circulation, those endotoxins can provoke inflammatory processes in pre-existing NAFLD and ALD [24]. Another contributing factor could be derived from the fact that alcohol is constantly produced by intestinal microbiota in the human gut [16]. Recent studies suggest that a dysbiosis in the intestine could lead to an increased endogenous production of ethanol, which can also trigger inflammation in the liver [32].…”

Section: Discussionmentioning

confidence: 99%

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Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease

Lemmer

Manka

Best

et al. 2022

JCM

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Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) have emerged as leading causes of chronic liver diseases worldwide. ALD and NAFLD share several pathophysiological patterns as well as histological features, while clinically, they are distinguished by the amount of alcohol consumed daily. However, NAFLD coexists with moderate alcohol consumption in a growing proportion of the population. Here, we investigated the effects of moderate alcohol consumption on liver injury, lipid metabolism, and gut microbiota in 30 NAFLD-patients. We anonymously assessed drinking habits, applying the AUDIT- and CAGE-questionnaires and compared subgroups of abstainers vs. low to harmful alcohol consumers (AUDIT) and Cage 0–1 vs. Cage 2–4. Patients who did not drink any alcohol had lower levels of γGT, ALT, triglycerides, and total cholesterol. While the abundance of Bacteroidaceae, Bifidobacteriaceae, Streptococcaceae, and Ruminococcaceae was higher in the low to harmful alcohol drinking cohort, the abundance of Rikenellaceae was higher in the abstainers. Our study suggests that even moderate alcohol consumption has an impact on the liver and lipid metabolism, as well as on the composition of gut microbiota.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease

Lemmer

Manka

Best

et al. 2022

JCM

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“…Liver diseases are generally divided into non-viral liver diseases and viral liver diseases [ 51 ]. Recent studies have found that gut microbiota and its metabolites, such as SCFAs, could prevent and manage several liver diseases, particularly non-viral liver diseases [ 52 , 53 ].…”

Section: The Bioactivities Of Scfasmentioning

confidence: 99%

Health Benefits and Side Effects of Short-Chain Fatty Acids

Xiong

Zhou

et al. 2022

Foods

155

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The gut microbiota and their metabolites could play an important role in health and diseases of human beings. Short-chain fatty acids (SCFAs) are mainly produced by gut microbiome fermentation of dietary fiber and could also be produced by bacteria of the skin and vagina. Acetate, propionate, and butyrate are three major SCFAs, and their bioactivities have been widely studied. The SCFAs have many health benefits, such as anti-inflammatory, immunoregulatory, anti-obesity, anti-diabetes, anticancer, cardiovascular protective, hepatoprotective, and neuroprotective activities. This paper summarizes health benefits and side effects of SCFAs with a special attention paid to the mechanisms of action. This paper provides better support for people eating dietary fiber as well as ways for dietary fiber to be developed into functional food to prevent diseases.

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“…In recent years, more and more studies have confirmed the role of probiotics in regulating the gut microbiota and maintaining the intestinal barrier [ 9 , 10 , 11 ]. At the same time, probiotics regulation of gut microbiota to alleviate alcohol-induced liver inflammation is a promising potential therapeutic approach [ 12 , 13 ]. Lactobacillus plantarum J26 ( L. plantarum J26) is a probiotic strain isolated from Chinese traditional fermented dairy products with good probiotic efficacy.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus plantarum J26 Alleviating Alcohol-Induced Liver Inflammation by Maintaining the Intestinal Barrier and Regulating MAPK Signaling Pathways

Cheng

Huo

et al. 2022

Nutrients

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Alcoholic liver disease (ALD), as a global health problem, is mainly caused by liver inflammation. Meanwhile, probiotics have been considered as a potential and promising strategy to prevent and alleviate ALD. This study aimed to investigate the ameliorative effect of pre-intaking with Lactobacillus plantarum J26 (L. plantarum J26) on alcohol-induced liver inflammation, with emphasis on the underlying mechanism for alleviating ALD. The results indicated that L. plantarum J26 could reduce the abundance of Gram-negative pathogenic bacteria by regulating the gut microbiota in mice with alcoholic liver injury, thereby reducing the lipopolysaccharide (LPS) content in the intestine. In addition, L. plantarum J26 could also maintain the intestinal barrier, prevent LPS from crossing the intestinal barrier to correct disorders of the gut–liver axis and then inhibit the activation of Toll-like receptor 4 (TLR4)-mediated MAPK signaling pathway, reducing liver inflammation and restoring liver functions. In conclusion, pre-intake of L. plantarum J26 could alleviate alcohol-induced liver inflammation, which may be closely related to the role of intestinal microbiota in regulating and maintaining the intestinal barrier and then regulating the MAPK signaling pathway.

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The intestinal microbiota as a therapeutic target in the treatment of NAFLD and ALD

Cited by 21 publications

References 172 publications

Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease

Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease

Health Benefits and Side Effects of Short-Chain Fatty Acids

Lactobacillus plantarum J26 Alleviating Alcohol-Induced Liver Inflammation by Maintaining the Intestinal Barrier and Regulating MAPK Signaling Pathways

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