The intestinal microbiota: from health to disease, and back

Nathan, Nayanan; Philpott, Dana J.; Girardin, Stephen E.

doi:10.1016/j.micinf.2021.104849

Cited by 20 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increasing evidences demonstrate the key role of probiotics in the management of patients with inflammatory bowel disease, allergy, autoimmune disease, and cancer (5), presenting a new avenue to address these limitations. The bacteria can stimulate the proliferation of beneficial bacteria of intestinal microbiota, thus maintaining a healthy intestinal environment or improving diseased one (6,7). Actually, daily probiotic use succeeded in reducing the adverse reactions of chemotherapy in several clinical trials (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Oral Administration of Probiotics Reduces Chemotherapy-Induced Diarrhea and Oral Mucositis: A Systematic Review and Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

BackgroundChemotherapy generally causes serious diarrhea and oral mucositis in cancer patients, and subsequently affects treatment. Oral administration of probiotics provides a therapeutic choice to address these limitations. This study aims to conduct a systematic review and meta-analysis on the efficacy of oral probiotic use in the management of the chemotherapy-induced adverse reactions, and to summarize the mechanisms underlying the action.MethodsWe searched PubMed, Embase, ClinicalTrials.gov, and Web of Science from the start of the study to its completion on Dec. 31, 2021. Risk of bias was assessed using Cochrane Collaboration's Tool. Statistical analysis of the acquired data was performed via the RevMan and the Stata Statistical Software. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO registration number: CRD42020220650).ResultsTwelve randomized controlled trials including 1,013 patients were recruited and analyzed via the standard procedure of meta-analysis. In contrast to the control group, orally taking probiotics significantly decreased the risk of chemotherapy-induced diarrhea (≥ 1 grade) (RR = 0.70; 95% Cl: 0.56, 0.88; P = 0.002) and oral mucositis (≥ 1 grade) (RR: 0.84; 95% Cl: 0.78, 0.91; P < 0.00001) at all grades. Further analysis found that severe diarrhea (≥ 2 grades) (RR: 0.50; 95% Cl: 0.32, 0.78; P = 0.002) and severe oral mucositis also significantly declined (≥ 3 grades) (RR: 0.66; 95% Cl: 0.55, 0.79; P < 0.00001) after oral probiotic use. Interestingly, the beneficial effects of probiotics displayed statistically significant only in Asian patients. Importantly, the more species of bacteria they took, the lower the incidences of the adverse reactions occurred. We used Egger's test P value to confirm that there is no publication bias.ConclusionsThis meta-analysis demonstrated that orally administrated probiotics has a potential to decrease chemotherapy-induced diarrhea and oral mucositis incidences. However, the efficacy of oral probiotic use against the adverse reactions needs to be further verified through more clinical trials, and the species and number of probiotics have to be optimized and standardized prior to clinical applications.Systematic Review Registrationhttps://www.crd.york.ac.uk, identifier: 220650.

show abstract

Section: Introductionmentioning

confidence: 99%

Oral Administration of Probiotics Reduces Chemotherapy-Induced Diarrhea and Oral Mucositis: A Systematic Review and Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Maintaining a normal gut and digestive tract function is one of the key elements to maintaining good health ( Sommer et al, 2017 ; Fassarella et al, 2021 ; Nathan et al, 2021 ). Studies have shown that A. cochinchinensis extract can treat gut damage caused by metal ions.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Asparagus cochinchinensis: A review of its botany, traditional uses, phytochemistry, pharmacology, and applications

Wang

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Asparagus cochinchinensis (Lour.) Merr. (A. cochinchinensis) is a traditional herbal medicine that is used to treat constipation, fever, pneumonia, stomachache, tracheitis, rhinitis, cataract, acne, urticaria. More than 90 compounds have been identified from different structural types in A. cochinchinensis, including steroidal saponins, C21-steroides, lignans, polysaccharides, amino acids, etc. These bioactive ingredients make A. cochinchinensis remarkable for its pharmacological effects on anti-asthma, anti-inflammatory, anti-oxidation, anti-tumor, improving Alzheimer’s disease, neuroprotection, gut health-promoting and so on. Moreover, A. cochinchinensis also plays an important role in food, health product, cosmetic, and other fields. This review focused on the research publications of A. cochinchinensis and aimed to summarize the advances in the botany, traditional uses, phytochemistry, pharmacology, and applications which will provide reference for the further studies and applications of A. cochinchinensis.

show abstract

“…4 Gut microbiota, defined as the trillions of microorganisms collectively inhabiting the gut lumen, is closely related to the development and manifestation of allergic diseases. 5 Emerging clinical and experimental evidence indicates that the structure and composition of gut microbiota undergo important changes in food allergy. 6 Antibiotics, like metronidazole, ampicillin, neomycin sulfate and vancomycin, induce gut microbiota dysbiosis that is related to the increased susceptibility and severity of food allergies.…”

Section: Introductionmentioning

confidence: 99%

Effects of rosmarinic acid on immune response and intestinal microbiota in ovalbumin‐induced intestinal allergy mice

Yang,

Jia,

Shang

et al. 2023

J Sci Food Agric

View full text Add to dashboard Cite

BACKGROUNDRosmarinic acid (RA) is an active polyphenol that is widely found in various edible herbs. This study explored the potential anti‐allergic activities and the underlying mechanisms of RA in ovalbumin (OVA)‐induced intestinal allergic mice.RESULTSForty female BALB/c mice were randomly divided into five groups: control group, model group (OVA sensitized/challenged), RA‐Low group (OVA sensitized/challenged, 30 mg kg−1 RA intervention), RA‐Middle group (OVA sensitized/challenged, 90 mg kg−1 RA intervention) and RA‐High group (OVA sensitized/challenged, 270 mg kg−1 RA intervention). RA effectively attenuated allergic reactions, including alleviating allergic symptoms and regulating the hypothermia of mice in the model group. Moreover, the anaphylactic mediator (OVA‐specific IgE, histamine and mMCP‐1) levels of OVA allergic mice were markedly decreased after RA intervention. Quantitative polymerase chain reaction analysis showed that RA significantly inhibited Th2 cytokine expression, while Th1 and Treg cytokines were markedly increased. 16S rRNA gene sequence analysis indicated that RA effectively regulated the richness and diversity of the intestinal microbiota in OVA allergic mice. At the phylum level, the relative abundance of Bacteroidetes and Firmicutes and the Firmicutes/Bacteroidetes ratio were altered by RA intervention. At the genus level, RA was found to regulate the disturbances in the relative abundance of Muribaculaceae, Lactobacillus and Prevotella.CONCLUSIONRA exhibited potential anti‐allergic activity in OVA allergic mice by regulating hypersensitive immune responses and the intestinal microbiota structure. These results provide important evidence that RA can be developed into a novel functional food‐derived ingredient against food allergy. © 2023 Society of Chemical Industry.

show abstract

The intestinal microbiota: from health to disease, and back

Cited by 20 publications

References 38 publications

Oral Administration of Probiotics Reduces Chemotherapy-Induced Diarrhea and Oral Mucositis: A Systematic Review and Meta-Analysis

Oral Administration of Probiotics Reduces Chemotherapy-Induced Diarrhea and Oral Mucositis: A Systematic Review and Meta-Analysis

Asparagus cochinchinensis: A review of its botany, traditional uses, phytochemistry, pharmacology, and applications

Effects of rosmarinic acid on immune response and intestinal microbiota in ovalbumin‐induced intestinal allergy mice

Contact Info

Product

Resources

About