The intimal proliferation in aortic-coronary saphenous vein grafts

Kern, William H.; Dermer, Gerald B.; Lindesmith, George G.

doi:10.1016/0002-8703(72)90070-1

Cited by 123 publications

(25 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…'-5 While early postoperative graft occlusLon is related in large part to technical failure or to grafting arteries that are either too small or are atherosclerotic,6 7 a significant incidence of late Saphenous vein bypass grafts medial hyperplasia.-12 Histological studies in man, 11,12 as well as in animals, 13' 14 have shown that after one month all aortocoronary vein grafts display some degree of fibrous proliferation in the intimal and medial layers. On angiograms, this process is characterized by diffuse or localized narrowing which may ultimately lead to occlusion of vein grafts.…”

Section: Additional Indexing Wordsmentioning

confidence: 99%

Angiographic Changes in Aortocoronary Vein Grafts:

et al. 1973

View full text Add to dashboard Cite

SUMMARYThe angiographic aspect of aortocoronary vein grafts was reviewed three years after operation in 43 patients. These patients had been previously subjected to two selective angiographic studies: two weeks and one year after operation. The review of these angiographic studies suggests that the attrition rate of aortocoronary vein grafts levels off after the first year. Only three occlusions (5.4%) were found on the three-year study in the 55 grafts which were patent on the studv conducted at one year. Two of the three occlusions occurred in grafts which had already displayed severe

show abstract

Section: Additional Indexing Wordsmentioning

confidence: 99%

Angiographic Changes in Aortocoronary Vein Grafts:

et al. 1973

View full text Add to dashboard Cite

show abstract

“…After adhering to the intima, platelets release mitogenic proteins, stimulating smooth muscle cell migration, resulting in intimal proliferation and hyperplasia. [7][8][9][10][11] After a year from surgery, arteriosclerosis is responsible for further saphenous vein graft failure. 12,13 Mural thrombi and intimal hyperplasia are the early stages of vein graft arteriosclerosis.…”

Section: Article See P 280mentioning

confidence: 99%

Understanding Saphenous Vein Graft Patency

Sabik

2011

Circulation

121

View full text Add to dashboard Cite

“…However, 20% or more of them fail within 5 years after surgery due to luminal narrowing caused by intimal hyperplasia [1][2][3][4][5][6] and rapidly progressive atherosclerosis [3][4][5][6][7][8][9][10]. Prior to the development of atherosclerosis, an early event that occurs in saphenous vein grafts (SVGs) is the thickening of the intima and the narrowing of the lumina as a result of diffuse intimal hyperplasia.…”

mentioning

confidence: 99%

“…Prior to the development of atherosclerosis, an early event that occurs in saphenous vein grafts (SVGs) is the thickening of the intima and the narrowing of the lumina as a result of diffuse intimal hyperplasia. Slight-to-moderate diffuse intimal hyperplasia develops in all SVGs, and this is generally considered to be an unavoidable intrinsic response of the vein to grafting [1,2,9]. In some SVGs, however, the intimal hyperplasia becomes so severe that it impedes blood flow, leading to graft failure.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Time-Dependent thickening of the intima in aortocoronary saphenous vein grafts: Clinicopathological analysis of 24 patients

et al. 1995

View full text Add to dashboard Cite

The present study was undertaken to investigate histological changes in aortocoronary saphenous vein grafts (SVGs) and the relationship between intimal thickening of the SVGs and the interval after grafting. The SVGs were divided into five groups according to the degree of intimal thickening and associated luminal narrowing: minimal thickening (0%-10% stenosis), slight thickening (11%-25% stenosis), slight-to-moderate thickening (26%-50% stenosis), moderate thickening (51%-75% stenosis), and severe thickening (76%-100% stenosis). SVGs showing minimal thickening had been implanted for 0-3 weeks, those with slight thickening for 2-13 weeks, those with slight-to-moderate thickening for 5-13 weeks, those with moderate thickening for 30-52 weeks, and those with severe thickening for 30-83 weeks. Thickening of the intima in SVGs (intimal hyperplasia) was time-dependent, and began as early as 2 weeks after the graft surgery. The change was diffuse and concentric, and observed from an aortic root to a coronary site. The major cell type involved in the intimal hyperplasia was the smooth muscle cell.

show abstract

The intimal proliferation in aortic-coronary saphenous vein grafts

Cited by 123 publications

References 4 publications

Angiographic Changes in Aortocoronary Vein Grafts:

Angiographic Changes in Aortocoronary Vein Grafts:

Understanding Saphenous Vein Graft Patency

Time-Dependent thickening of the intima in aortocoronary saphenous vein grafts: Clinicopathological analysis of 24 patients

Contact Info

Product

Resources

About