The Intimate Mechanism of Replacements in d ⁸ Square‐Planar Complexes

Exploring Trans Effect Concept in Pt(II) Complexes through the Quantum Theory of Atoms in Molecules and Chemical Bond Overlap Model Perspectives

“…The employment of this trans series facilitates deliberate syntheses aimed at achieving specific desired products by solely assessing the strength of the ligands' trans effects. [5,6] Beyond its fundamental nature, the significance of the trans effect extends to comprehending and constructing reaction mechanisms that elucidate the interaction between platinum-based anticancer compounds and biological targets within an aqueous environment. [7][8][9][10] A well-structured mechanism stands as a crucial factor in advancing the development of more efficient potential drug candidates, particularly in the realm of new anticancer agents with enhanced pharmacokinetic profiles.…”

Substitution kinetics of platinum N,N,N’,N’-Tetrakis (2-pyridyl methyl) octane diamine aqua complex with thiourea, glutathione and L-cysteine nucleophiles

“…Complexes of platinum have in particular attracted extensive research because they form more stable planar complexes. For decades more effort has been directed to investigations on the kinetics and mechanisms of their reactions [15][16][17][18] , with most studies focused on ligand substitution at square-planar centres of d [8] transition metal ions such as platinum(ll) and palladium(II) [19] . These studies are largely connected to understanding the mechanisms of their activities as homogeneous catalysts and anti-tumour drugs [20][21][22] .…”

Dissociative pathway of the [Pd(2,2′-bipyridyl)(2-picoline)2]2+ cation

“…Moreover 1 H NMR spectrum at rt shows that about 18% of 1 is solvolysed in the [Pd(bipy)(2pic)DMF] 2+ (2) complex and free 2-picoline (f). Isomerization, on the basis of these observations, and in the lack of more specific kinetic data, could be supposed to occur through the well known solvolytic pathway of square-planar complexes characterized by a substrate/solvent preequilibrium followed by fast attack of the nucleophile on the solvento-species [3,11]. We here report a thorough kinetic analysis of the syn-anti exchange performed by quantitative weighting of 2D-EXSY NMR spectra [12] (see Fig.…”