The intracellular degradation of poly(ε‐caprolactone)

Woodward, Stephen; Brewer, P. S.; Moatamed, Farhad; Schindler, A.; Pitt, Colin G.

doi:10.1002/jbm.820190408

Cited by 357 publications

(244 citation statements)

References 11 publications

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“…PCL is a semicrystalline polymer, has a very low glass-transition temperature (around −62°C), and thus is highly elastic at room or body temperature. Although PCL degrades by various mechanisms under physiological conditions [23,24], the degradation rate is too slow, making it less attractive [3]. Segmented PU allow for structural variations to achieve elastomeric properties [25].…”

Section: Biomimetic Mechanical Propertiesmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

1,212

819

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Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular-matrix environments for tissue regeneration. It is often beneficial for the scaffolds to mimic certain advantageous characteristics of the natural extracellular matrix, or developmental or would healing programs. This article reviews current biomimetic materials approaches in tissue engineering. These include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the extracellular matrix on various levels, approaches to emulate cell-extracellular matrix interactions, and biologic delivery strategies to recapitulate a signaling cascade or developmental/would-healing program. The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration.

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Section: Biomimetic Mechanical Propertiesmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

1,212

819

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“…PCL is an important class of biocompatible and biodegradable synthetic polymers [32][33][34] which has been approved for biomedical applications by the US Food and Drug Administration (FDA). PCL is a semi-crystalline polymer that has a melting temperature (T m ) above which the mobility of polymer chains changes dramatically.…”

Section: Modulation Of Shape-memory Temperaturementioning

confidence: 99%

The taming of the cell: shape-memory nanopatterns direct cell orientation

Ebara¹,

Uto²,

Idota³

et al. 2014

IJN

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We report here that the direction of aligned cells on nanopatterns can be tuned to a perpendicular direction without use of any biochemical reagents. This was enabled by shape-memory activation of nanopatterns that transition from a memorized temporal pattern to the original permanent pattern by heating. The thermally induced shape-memory nanopatterns were prepared by chemically crosslinking semi-crystalline poly(ε-caprolactone) (PCL) in a mold to show shape-memory effects over its melting temperature (T m = 33°C). Permanent surface patterns were first generated by crosslinking the PCL macromonomers in a mold, and temporary surface patterns were then embossed onto the permanent patterns. The temporary surface patterns could be easily triggered to transition quickly to the permanent surface patterns by a 37°C heat treatment, while surface wettability was independent of temperature. To investigate the role of dynamic and reversible surface nanopatterns on cell alignment on the PCL films before and after a topographic transition, NIH 3T3 fibroblasts were seeded on fibronectin-coated PCL films with a temporary grooved topography (grooves with a height of 300 nm and width of 2 μm were spaced 9 μm apart). Interestingly, cells did not change their direction immediately after the surface transition. However, cell alignment was gradually lost with time, and finally cells realigned parallel to the permanent grooves that emerged. The addition of a cytoskeletal inhibitor prevented realignment. These results clearly indicate that cells can sense dynamic changes in the surrounding environments and spontaneously adapt to a new environment by remodeling their cytoskeleton. These findings will serve as the basis for new development of spatiotemporal tunable materials to direct cell fate.

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“…Under certain circumstances, it is possible to enzymatically degrade crosslinked PCL (termed enzymatic surface erosion). Low molecular-weight fragments of PCL are also reportedly absorbed by macrophages intercellularly [9]. The PCL material has a significantly slower biodegradation rate than other BDP materials, making it suitable for design of long-term implantable systems such as apronor, a US FDA-approved contraceptive device [lo].…”

Section: Introductionmentioning

confidence: 99%

Improvement of Mechanical Properties of Polycaprolactone (PCL) by Addition of Nano-Montmorillonite (MMT) and Hydroxyapatite (HA)

Haq

Wahab

Mat

2013

AMM

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Abstract. For many years, researcher have focused on developing a medical part of human body fi-om polymer as to replace metal. This report described the mechanical characteristic of biodegradable Polycaprolactone (PCL) blend with nano-Montmorillonite (MMT) and Hydroxyapatite (HA). The amount of nano-MMT is varies from 2 to 4 by weight % meanwhile the amount of HA is fixed to 10 by weight percentage (wt %). The addition of nano-MMT and HA filler is to tune and indirectly improve the mechanical properties of PCL. These are proven by carrying out the tensile, and also flexural test for samples which is injected from injection molding machine. Both the tensile and flexural test are conducted using Shimadzu AG-I Unversal Testing Machine with 10kN capacity. From the analysis it is found that overall PCL/MMT/HA composites gives better result in both tensile and flexural analysis compare to PCL/MMT composite. PCLIMMTIHA composite with 2 wt% of MMT and 10 wt% of HA have indicated the highest tensile modulus, meanwhile PCL/MMT/HA composite with 4 wt% MMT and 10 wt% HA have plotted the highest flexural strength and modulus value.

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The intracellular degradation of poly(ε‐caprolactone)

Cited by 357 publications

References 11 publications

Biomimetic materials for tissue engineering

Biomimetic materials for tissue engineering

The taming of the cell: shape-memory nanopatterns direct cell orientation

Improvement of Mechanical Properties of Polycaprolactone (PCL) by Addition of Nano-Montmorillonite (MMT) and Hydroxyapatite (HA)

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