The Intracellular Distribution of Histamine in Dog's Liver

Hagen, Paul

doi:10.1111/j.1476-5381.1954.tb00824.x

Cited by 30 publications

(11 citation statements)

References 7 publications

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“…Since the mast cell granules appear in the mitochondrial fraction on differential centrifugation (21)--they may indeed be transformed mitochondria (22)--the reports of the mitochondrial location of histamine (23)(24)(25) present no strong argument against the idea that heparin and histamine, very likely component parts of a large complex molecule, are contained in mast cell granules.…”

Section: Discussionmentioning

confidence: 99%

Mast Cells as Sources of Tissue Histamine

Graham

Lowry

Wahl

et al. 1955

The Journal of Experimental Medicine

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Enumeration of mast cells and determination of histamine in sections of dog skin and dog lung have shown that the regions of the tissue rich in mast cells are also rich in histamine. In the skin, the outer layers of the dermis contain higher concentrations of histamine and mast cells than any other region. Average values of the histamine content and mast cell count for dog liver, heart, muscle, and kidney, and for beef liver parenchyma and capsule, also exhibit a positive relationship between these two parameters, although the amount of histamine found per mast cell varied from 7 µµg. in dog skin to 32 µµg. in beef liver capsule. When the size of the mast cells was taken into account, the intracellular concentration of histamine was found to be of the same order (about 0.4 molar) for all the tissues examined except skin and kidney. In both dog skins analyzed, the intracellular concentration was about 0.1 molar. In kidney both mast cell and histamine values were too low for accurate estimation. The concentration of histamine in the mast cells investigated was much greater than the concentration in human basophils, the blood elements richest in histamine. The mechanism of the localization of histamine in mast cells is briefly considered.

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Section: Discussionmentioning

confidence: 99%

Mast Cells as Sources of Tissue Histamine

Graham

Lowry

Wahl

et al. 1955

The Journal of Experimental Medicine

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“…The enzyme appears to be in the cell sap, since a tissue extract subjected to a gravitational force of 90,000 g had an enzyme activity comparable to that of minced tissue (Table IX) Hagen (1954), which showed that most of the histamine in the dog liver is in the mitochondrial fraction.…”

Section: N G Wa Ton Potentiation or Inhibition Of Histidine Decarbomentioning

confidence: 99%

Studies on Mammalian Histidine Decarboxylase

Waton

1956

British Journal of Pharmacology and Chemotherapy

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Histamine is present in most mammalian tissues, but its mode of formation is still not clear. According to Blaschko (1945) there are two main theories: (1) Histamine is a vitamin, formed outside the body by bacterial decarboxylation of dietary histidine in the alimentary tract. (2) Histamine is a metabolite, formed from circulating histidine by the histidine decarboxylase present in some tissues of the body.That bacteria form histamine by decarboxylation of histidine is well known (

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“…solution than in 0 1 ml., but in neither case was there any evidence of diminished loss from the particles through this addition of histamine to the surrounding medium. Histamine release by octylamine and compound 48/80 Hagen (1954) showed that octylamine (10-3) released histamine from intracellular particles prepared from dog's liver; octylamine (10-4) and compound 48/80 (10-4) were inactive. We have made a quantitative study of histamine release by these compounds from the mitochondrial fraction of guinea-pig lung.…”

Section: Intracellular Distribution Of Histaminementioning

confidence: 99%