The Intravenous Use of Oral Acetylcysteine (Mucomyst) for the Treatment of Acetaminophen Overdose

N-Acetylcysteine Decreases Angiotensin II Receptor Binding in Vascular Smooth Muscle Cells

“…NAC and ␣-lipoic acid both are in clinical use at present, the former to treat acetaminophen toxicity (43,44) and to provide prophylaxis against contrast-induced acute renal failure (45) and the latter for diabetic neuropathy (46,47). Our results raise the possibility that these agents may ameliorate renal and vascular diseases mediated by Ang II, especially if they mimic dithiothreitol in achieving the favorable combination of lower binding to AT 1 receptors (our study) and increased binding to AT 2 receptors (26).…”