The intricate dance of tumor evolution: Exploring immune escape, tumor migration, drug resistance, and treatment strategies

Guo, Xiaojun; Bian, Xiaonan; Li, Yitong; Zhu, Xiao; Zhou, Xiaorong

doi:10.1016/j.bbadis.2024.167098

Cited by 2 publications

(1 citation statement)

References 243 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mutations in genes and aberrant DNA methylation are recognized as critical factors that disrupt gene expression in cancers, markedly in uencing both the onset and progression of the disease. Such genetic alterations predominantly affect key cellular processes including proliferation, apoptosis, and repair mechanisms [41,42] . Typically, genetic changes associated with cancer manifest as point mutations, deletions, or chromosomal rearrangements.…”

Section: Discussionmentioning

confidence: 99%

A comprehensive bioinformatics analysis of THOC3 highlights its potential role in pan-cancer and clinical significance in lung adenocarcinoma

Zhang,

Zhao,

Zhao

et al. 2024

Preprint

View full text Add to dashboard Cite

THOC3, a crucial component of the THO complex, is involved in mRNA biosynthesis and export. Studies have shown that dysregulation of THOC3 is linked to various aspects of tumorigenesis, including tumor initiation, progression, and metastasis. In this study, we utilized a comprehensive bioinformatics analysis to explore the role of THOC3 in different types of cancer. Our analysis of different types of data helped us understand how THOC3 contributes to cancer at the molecular level, and its clinical significance. Moreover, our immune analysis revealed notable correlations between THOC3 and multiple immune-related signaling pathways. Our findings highlight the potential oncogenic role of THOC3 across different types of cancer and propose dysregulation of THOC3 as a key driver in tumor development. Furthermore, the associations between THOC3 and immune-related signaling pathways indicate its potential as a target for further experimental validation and investigation in the realm of immunotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%