The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987–2020)

Hai, Yang; Wei, Mei‐Yan; Wang, Chang‐Yun; Gu, Yu‐Cheng; Shao, Chang‐Lun

doi:10.1007/s42995-021-00101-2

Cited by 79 publications

(40 citation statements)

References 357 publications

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“…The bioactivity found in the Streptomyces strains detected in this work may be justified by the action of molecules such as diketopiperazines, N-acetyltyramine, antibiotic MKN-003B, germicidin G, surugamide A and E, blastmycin, antimycins A11 and A13, ansalactam A, corynecin I and chloramphenicol, as well as non-identified molecules such as C 13 H 22 O 3 , C 20 H 13 N 3 O 6 , C 22 H 44 O 12 , C 27 H 53 N 5 O 10 and C 23 H 13 ClO 4 S 2 . This last molecule seems to be of special interest, as the presence of a halogen (chlorine) and two sulphur atoms may indicate potential bioactivity [ 119 , 120 ]. Overall, these results suggest the relevance of the genus Streptomyces for the discovery of natural products and drug discovery research, as the extracts of the strains studied here showed antibacterial activity and putatively contain bioactive compounds and possible novel natural products.…”

Section: Discussionmentioning

confidence: 99%

iChip-Inspired Isolation, Bioactivities and Dereplication of Actinomycetota from Portuguese Beach Sediments

et al. 2022

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Oceans hold a stunning number of unique microorganisms, which remain unstudied by culture-dependent methods due to failures in establishing the right conditions for these organisms to grow. In this work, an isolation effort inspired by the iChip was performed using marine sediments from Memoria beach, Portugal. The isolates obtained were identified by 16S rRNA gene analysis, fingerprinted using BOX-PCR and ERIC-PCR, searched for the putative presence of secondary metabolism genes associated with polyketide synthase I (PKS-I) and non-ribosomal peptide synthetases (NRPS), screened for antimicrobial activity against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 29213, and had bioactive extracts dereplicated by LC/HRMS. Of the 158 isolated strains, 96 were affiliated with the phylum Actinomycetota, PKS-I and NRPS genes were detected in 53 actinomycetotal strains, and 11 proved to be bioactive (10 against E. coli, 1 against S. aureus and 1 against both pathogens). Further bioactivities were explored using an “one strain many compounds” approach, with six strains showing continued bioactivity and one showing a novel one. Extract dereplication showed the presence of several known bioactive molecules and potential novel ones in the bioactive extracts. These results indicate the use of the bacteria isolated here as sources of new bioactive natural products.

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Section: Discussionmentioning

confidence: 99%

iChip-Inspired Isolation, Bioactivities and Dereplication of Actinomycetota from Portuguese Beach Sediments

et al. 2022

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“…The well-known conotoxin, ecteinascidin 743 (ET-743), and penicillin are examples of natural sulfur-containing clinical drugs. Furthermore, many sulfur-containing drugs are derived from natural products, e.g., phthalascidin and ixabepilone for cancer treatments, rosuvastatin for hyperlipidemia, and dalfopristin and quinupristin for infectious diseases [7].…”

Section: Introductionmentioning

confidence: 99%

Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors

Ibrahim

Omar

Bagalagel

et al. 2022

Plants

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Naturally, thiophenes represent a small family of natural metabolites featured by one to five thiophene rings. Numerous plant species belonging to the family Asteraceae commonly produce thiophenes. These metabolites possessed remarkable bioactivities, including antimicrobial, antiviral, anti-inflammatory, larvicidal, antioxidant, insecticidal, cytotoxic, and nematicidal properties. The current review provides an update over the past seven years for the reported natural thiophene derivatives, including their sources, biosynthesis, spectral data, and bioactivities since the last review published in 2015. Additionally, with the help of the SuperPred webserver, an AI (artificial intelligence) tool, the potential drug target for the compounds was predicted. In silico studies were conducted for Cathepsin D with thiophene derivatives, including ADMET (drug absorption/distribution/metabolism/excretion/and toxicity) properties prediction, molecular docking for the binding interaction, and molecular dynamics to evaluate the ligand–target interaction stability under simulated physiological conditions.

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“…Investigating new bioactive natural products from marine fungi is a major and constant research focus in our laboratory [ 21 , 22 , 23 , 24 ]. Natural product researchers also face the challenge of targeting the discovery of bioactive compounds from a microbial resource library.…”

Section: Introductionmentioning

confidence: 99%

Integrating Activity-Guided Strategy and Fingerprint Analysis to Target Potent Cytotoxic Brefeldin A from a Fungal Library of the Medicinal Mangrove Acanthus ilicifolius

Wang

Jing

et al. 2022

Marine Drugs

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Mangrove-associated fungi are rich sources of novel and bioactive compounds. A total of 102 fungal strains were isolated from the medicinal mangrove Acanthus ilicifolius collected from the South China Sea. Eighty-four independent culturable isolates were identified using a combination of morphological characteristics and internal transcribed spacer (ITS) sequence analyses, of which thirty-seven strains were selected for phylogenetic analysis. The identified fungi belonged to 22 genera within seven taxonomic orders of one phyla, of which four genera Verticillium, Neocosmospora, Valsa, and Pyrenochaeta were first isolated from mangroves. The cytotoxic activity of organic extracts from 55 identified fungi was evaluated against human lung cancer cell line (A-549), human cervical carcinoma cell (HeLa), human hepatoma cells (HepG2), and human acute lymphoblastic leukemia cells (Jurkat). The crude extracts of 31 fungi (56.4%) displayed strong cytotoxicity at the concentration of 50 μg/mL. Furthermore, the fungus Penicillium sp. (HS-N-27) still showed strong cytotoxic activity at the concentration of 25 µg/mL. Integrating cytotoxic activity-guided strategy and fingerprint analysis, a well-known natural Golgi-disruptor and Arf-GEFs inhibitor, brefeldin A, was isolated from the target active strain HS-N-27. It displayed potential activity against A549, HeLa and HepG2 cell lines with the IC50 values of 101.2, 171.9 and 239.1 nM, respectively. Therefore, combining activity-guided strategy with fingerprint analysis as a discovery tool will be implemented as a systematic strategy for quick discovery of active compounds.

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The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987–2020)

Cited by 79 publications

References 357 publications

iChip-Inspired Isolation, Bioactivities and Dereplication of Actinomycetota from Portuguese Beach Sediments

iChip-Inspired Isolation, Bioactivities and Dereplication of Actinomycetota from Portuguese Beach Sediments

Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors

Integrating Activity-Guided Strategy and Fingerprint Analysis to Target Potent Cytotoxic Brefeldin A from a Fungal Library of the Medicinal Mangrove Acanthus ilicifolius

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