The knowledge and application of pharmacology is essential for safe prescribing and administration of drugs. In this narrative review, the challenges to pharmacology education in the medical curricula were broadly identified to include issues around content and pedagogies. The increasing number of approved drugs and drug targets, expanding field of pharmacology and the often‐changing treatment guidelines and board‐defined competencies can make pharmacology education in the medical curriculum daunting. There has been a consensus around the deployment of innovative medical curricula with emphasis on vertical and horizontal integration. This strategy, effective as it has been, presents new challenges to pharmacology education. As a discipline often perceived by students to be hard‐to‐learn, the future of pharmacology education must include heavy reliance on active learning strategies. The continuing utilization of problem‐based, team‐based and case‐based learning can be complemented with personalized learning which aims to identify the learning gaps in individual students. Technology‐inspired student engagement can foster pharmacology learning and retention. Early exposure to pharmacology from premedical preparation through an enduring across‐the‐level integration can be an effective way to enhance pharmacology learning in the medical curricula.