2003
DOI: 10.1128/mcb.23.2.607-619.2003
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The inv(16) Fusion Protein Associates with Corepressors via a Smooth Muscle Myosin Heavy-Chain Domain

Abstract: Inversion (16) is one of the most frequent chromosomal translocations found in acute myeloid leukemia (AML), occurring in over 8% of AML cases. This translocation results in a protein product that fuses the first 165 amino acids of core binding factor ␤ to the coiled-coil region of a smooth muscle myosin heavy chain (CBF␤/SMMHC). CBF␤ interacts with AML1 to form a heterodimer that binds DNA; this interaction increases the affinity of AML1 for DNA. The CBF␤/SMMHC fusion protein cooperates with AML1 to repress t… Show more

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Cited by 149 publications
(151 citation statements)
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“…RUNX1 residues 1-204 are also retained in the t(8;21) fusion protein, which again predicts that this fusion protein can recruit SUV39H1, although this association may negatively affect DNA binding (Chakraborty et al, 2003). Although the inv(16) contains no homology to RUNX1, it acts as a corepressor for RUNX1 (Lutterbach et al, 1999;Durst et al, 2003). Our initial analysis failed to detect an association between SUV39H1 and the inv(16) fusion protein.…”
Section: Discussionmentioning
confidence: 84%
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“…RUNX1 residues 1-204 are also retained in the t(8;21) fusion protein, which again predicts that this fusion protein can recruit SUV39H1, although this association may negatively affect DNA binding (Chakraborty et al, 2003). Although the inv(16) contains no homology to RUNX1, it acts as a corepressor for RUNX1 (Lutterbach et al, 1999;Durst et al, 2003). Our initial analysis failed to detect an association between SUV39H1 and the inv(16) fusion protein.…”
Section: Discussionmentioning
confidence: 84%
“…In addition to the association between SUV39H1 and RUNX1, RUNX1 can bind to HDAC1, HDAC3 and HDAC9 and to a lesser degree HDAC2, HDAC5 and HDAC6 (Durst et al, 2003). Therefore, we tested whether HDAC1 or HDAC3 might also contact the motifs that are required for repression within RD2 by screening these factors against the collection of GAL4-RUNX1 fusion proteins.…”
Section: Histone Deacetylases Also Contact Rd2mentioning
confidence: 99%
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