Lifestyle modifications, including the restriction of dietary sodium intake, have been recommended worldwide as first-line treatment for people with elevated blood pressure. 1 Recent evidence has further confirmed the benefits of salt substitutes in terms of reduced rates of stroke, major cardiovascular events, and death. 2 The study by Liu et al 3 explores the acceptability of, and adherence to, a salt substitute as well as the barriers to sodium reduction. In this mixed-methods investigation conducted in rural China, participants from the Salt Substitute and Stroke Study were used. 2 A total of 1025 participants completed the knowledge, attitude, and practice questionnaire regarding salt intake, while 30 participants receiving salt substitutes completed qualitative interviews. Despite finding that the overall acceptability of the use of salt substitutes in daily life among rural participants was high, an inadequate awareness of the recommended daily salt intake was reported. In addition, participants commonly reported being unaware of the health benefits of consuming salt substitutes and reported still favoring the use of regular salt when preparing pickled foods. Barriers to sustainable adoption of salt substitutes included insufficient health education, self-perceived high costs, and contextual factors (such as preference for habitual flavors of food). The authors suggested that these barriers should be taken into account in formulating sodium reduction strategies in rural areas.