The investigation of antibiotic residues, antibiotic resistance genes and antibiotic-resistant organisms in a drinking water reservoir system in Germany

Voigt, Alexander; Ciorba, Patrick; Döhla, Manuel; Exner, Martin; Felder, Carsten; Lenz-Plet, Franziska; Sib, Esther; Skutlarek, Dirk; Schmithausen, Ricarda Maria; Faerber, H.A.

doi:10.1016/j.ijheh.2020.113449

Cited by 67 publications

(28 citation statements)

References 54 publications

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“…In 2015, sulfapyridine, sulfamethoxazole, ciprofloxacin, enrofloxacin, levofloxacin, norfloxacin, chloramphenicol, florfenicol, doxycycline, and metronidazole were detected in tap water at concentrations ranging between 0.5 and 21.4 ng/L in rural Shandong province, eastern China [99]. Water from a river system in Germany supplying a drinking water reservoir was found to contain residues of sulfamethoxazole (up to 0.40 µg/L), trimethoprim (up to 0.39 µg/L), and macrolide antibiotics, such as clarithromycin (up to 0.60 µg/L), downstream from two sewage treatment plants [100]. A study of two treatment plants in Bagdad, Iraq, identified ciprofloxacin, levofloxacin, and amoxicillin in raw water and ciprofloxacin and levofloxacin in the finished water [101].…”

Section: Antibiotics Arb and Arg In Water Wastewater And Sewage Smentioning

confidence: 99%

Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Serwecińska

2020

Water

495

206

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The release of antibiotics to the environment, and the consequences of the presence of persistent antimicrobial residues in ecosystems, have been the subject of numerous studies in all parts of the world. The overuse and misuse of antibiotics is a common global phenomenon, which substantially increases the levels of antibiotics in the environment and the rates of their spread. Today, it can be said with certainty that the mass production and use of antibiotics for purposes other than medical treatment has an impact on both the environment and human health. This review aims to track the pathways of the environmental distribution of antimicrobials and identify the biological effects of their subinhibitory concentration in different environmental compartments; it also assesses the associated public health risk and government policy interventions needed to ensure the effectiveness of existing antimicrobials. The recent surge in interest in this issue has been driven by the dramatic increase in the number of infections caused by drug-resistant bacteria worldwide. Our study is in line with the global One Health approach.

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Section: Antibiotics Arb and Arg In Water Wastewater And Sewage Smentioning

confidence: 99%

Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Serwecińska

2020

Water

495

206

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“…Unfortunately, despite the clinical benefits of antibiotics, some of them are not completely metabolized by humans or animals during consumption, resulting in wide side effects [10,11]. Therefore, discharging antibiotics into the aqueous environments (rivers, groundwater, and lakes) without adequate treatment results in irreparable harm to human health, especially the promotion of antibiotic resistance of pathogenic microorganisms [12,13], among populations who drink it on a regular basis.…”

Section: Introductionmentioning

confidence: 99%

Nano-Size Biomass Derived from Pomegranate Peel for Enhanced Removal of Cefixime Antibiotic from Aqueous Media: Kinetic, Equilibrium and Thermodynamic Study

Bidhendi

Poursorkh

Sereshti

et al. 2020

IJERPH

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Nano-sized activated carbon was prepared from pomegranate peel (PG-AC) via NaOH chemical activation and was fully characterized using BET, FT-IR, FE-SEM, EDX, and XRD. The newly synthesized PG-AC was used for cefixime removal from the aqueous phase. The effective parameters on the adsorption process, including solution pH (2–11), salt effect (0–10%), adsorbent dosage (5–50 mg), contact time (5–300 min), and temperature (25–55 °C) were examined. The experimental adsorption equilibrium was in close agreement with the type IV isotherm model set by the International Union of Pure and Applied Chemistry (IUPAC). The adsorption process was evaluated with isotherm, kinetic, and thermodynamic models and it is were well fitted to the Freundlich isotherm (R2 = 0.992) and pseudo-second-order model (R2 = 0.999). The Langmuir isotherm provided a maximum adsorption capacity of 181.81 mg g−1 for cefixime uptake onto PG-AC after 60 min at pH 4. Hence, the isotherm, kinetic and thermodynamic models were indicated for the multilayer sorption followed by the exothermic physical adsorption mechanism.

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“…In addition, these bacteria are able to spread their genes into water-indigenous microbes, which also contain resistance genes (Baquero et al 2008). They are not completely mitigated during treatment processes in sewage treatment plants; therefore, they can be distributed to the aquatic environment (Michael et al 2013;Rizzo et al 2013;Hembach et al 2019;Voigt et al 2020). Given this spread of ARGs in surface water and insufficient degradation in sewage treatment plants, antibiotic resistance poses a great threat to public health and to ecology (Krzeminski et al 2020;Thakali et al 2020;Voigt et al 2020).…”

Section: Introductionmentioning

confidence: 99%

“…They are not completely mitigated during treatment processes in sewage treatment plants; therefore, they can be distributed to the aquatic environment (Michael et al 2013;Rizzo et al 2013;Hembach et al 2019;Voigt et al 2020). Given this spread of ARGs in surface water and insufficient degradation in sewage treatment plants, antibiotic resistance poses a great threat to public health and to ecology (Krzeminski et al 2020;Thakali et al 2020;Voigt et al 2020). Furthermore, the World Health Organization (WHO), the United Nations (UN), and the European Union consider antimicrobial resistance (AMR) as a global public health threat (World Health Organization 2015; United Nations 2016; Krzeminski et al 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Wastewater and wastewater treatment plants are regarded as a source of antibiotic resistance. Wastewater has fecal residues including antibiotic resistance bacteria, antibiotic resistance genes, metals, organic pollutants, and the residue of antibiotics (Thakali et al 2020 ; Voigt et al 2020 ). In addition, these bacteria are able to spread their genes into water-indigenous microbes, which also contain resistance genes (Baquero et al 2008 ).…”

Section: Introductionmentioning

confidence: 99%

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An alternative material for an effective treatment technique proposal in the light of bibliometric profile of global scientific research on antibiotic resistance and Escherichia coli

Şahin

Akpınar

Sivri

2020

Environ Monit Assess

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Antibiotic resistance is considered by the countries to be a global health issue and a huge threat to public health. The reduction of resistant microorganisms from water/wastewater is of importance in environmental sciences since they are resistant in the aquatic environment. In this study, a bibliometric analysis of literature from the field of environmental science in water ecosystems from 2015 to 2019 was carried out using the keywords “Antibiotic Resistance (AR)” and “Escherichia coli”. Furthermore, using the keywords of “Fresh Water,” “Sea Water,” and “Waste Water,” 155, 52, and 57 studies were discovered, respectively. It is found that 217 studies of the total 2115 studies investigated on AR are mostly performed in the “Waste Water” by considering human health. Given the studies, an up-to-date solution should be proposed since the release of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) from wastewater treatment plants needs to be mitigated. For this reason, it is obvious that working on micro and macro ecosystems will increase the probability of solutions in antibiotic resistance. A discussion of removal techniques for coliform bacteria, particularly antibiotic resistant Escherichia coli, was presented. One of the unique values of this study is to offer an innovative solution that removing them by metal-organic frameworks (MOFs) are emerging crystalline hybrid materials. MOFs are used for environmental, biological, and food antimicrobial substances efficiently. Therefore, we can give inspiration to the future studies of antimicrobial resistance removal via adsorption using MOFs as adsorbents.

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The investigation of antibiotic residues, antibiotic resistance genes and antibiotic-resistant organisms in a drinking water reservoir system in Germany

Cited by 67 publications

References 54 publications

Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Nano-Size Biomass Derived from Pomegranate Peel for Enhanced Removal of Cefixime Antibiotic from Aqueous Media: Kinetic, Equilibrium and Thermodynamic Study

An alternative material for an effective treatment technique proposal in the light of bibliometric profile of global scientific research on antibiotic resistance and Escherichia coli

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