The investigation of host genetic variants of toll-like receptor 7 and 8 in COVID-19

Bağci, Gökhan; Gündoğdu, Oğuz; PEKTAŞ, Ayşe Nur; Bağcı, Binnur; Avcı, Onur; Gürsoy, Sinan; Kaygusuz, Kenan; Elaldı, Nazif

doi:10.1080/15257770.2023.2176515

Cited by 3 publications

(3 citation statements)

References 42 publications

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“…TLR7 rs179009 SNP can be thoughted as a risk agent which rises susceptibility to the infection in the male patients with COVID-19. Bagci et al (2023) highlighted that studies are required to show the role of TLR7 rs179009 SNP in patients infected with SARS-CoV-2 patients (18). In our study, we studied on 150 patients with COVID-19 and individuals who carried TLR7 rs179009 SNP G allele and mutant GG genotype had higher risk when COVID-19 case compared with healthy individuals.…”

Section: Discussionmentioning

confidence: 96%

“…TLR7 rs179008 polymorphism was linked with increased susceptibility to COVID-19 infection (22). According to the study of Bagci et al (2023), TLR7 rs179009 A allele had a higher frequency in COVID-19 in male patients with comorbidity. TLR7 rs179009 SNP can be thoughted as a risk agent which rises susceptibility to the infection in the male patients with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“…TLR9 highly take the place in intracellular departments and performs important gatekeeper in the detection and treatment of viral disease (23).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Relationship of Toll-Like Receptor 7, 9, and 10 Polymorphisms and the Severity of Coronavirus Disease 2019

Bayyurt,

Baltacı,

Şahin

et al. 2024

Jpn J Infect Dis

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COVID-19 is an pandemic that is still affecting today and has caused many deaths. Toll-like receptor (TLR) have an important role in the binding of disease agents to host cell, disease susceptibility and severity, host disease resistance, In this study, we investigated frequencies of TLR7 (C.4-151 A/G), TLR9 (T-1486C and G2848A), and TLR10 (720A/C and 992T/A) single nucleotide polymorphisms (SNPs) in 150 cases with COVID-19 and 171 control samples. We also observed whether TLR7, 9, and 10 were related with the COVID-19 disease severity. Furthermore, we analyzed the association between COVID-19 and some clinical parameters. Polymerase chain reaction (PCR) based on restriction fragment length polymorphism (RFLP) was performed for TLR7, 9 and 10 SNPs. TLR7 C.4-151 A/G G allele and GG genotype; TLR9 T-1486C C allele and TC, CC genotypes; and TLR10 720A/C C allele; TLR10 992T/A A allele and AA genotype frequencies were statistic significant in cases compared with controls (P<0.05*). In addition, there was a statistic significant difference in the distribution of TLR7, 9, and 10 allele and genotype frequencies between severity groups (P<0.05*). Our findings suggest that TLR7, 9, and 10 polymorphisms may be crucial on clinical course or susceptibility of the infection.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Relationship of Toll-Like Receptor 7, 9, and 10 Polymorphisms and the Severity of Coronavirus Disease 2019

Bayyurt,

Baltacı,

Şahin

et al. 2024

Jpn J Infect Dis

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Toll-like receptors polymorphisms and COVID-19: a systematic review

dos Santos,

Ferreira

et al. 2024

Mol Cell Biochem

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Association of Several Innate Immune Response Gene Polymorphisms with COVID-19 in Turkish Population

Soyöz,

Altın,

Eldem

et al. 2024

Ege Tıp Dergisi

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Aim: The coronavirus disease 2019 (COVID-19) was caused by severe acute respiratory syndrome 2 virus (SARS-CoV-2), has spread globally. Gender and age have been established as risk factors for severe COVID-19. However, these factors do not fully explain the effects on disease risk. According to researchers, single nucleotide polymorphisms (SNPs) on multiple genes could affect the severity of COVID-19. The progression of viral diseases depends on the characteristics of the patient's innate immunity. The effectiveness of the innate immune system depends on the patient's genetic factors, including SNPs in the TLR, CCR5, and RIG-I genes. In this study, we researched the association of allele and genotype frequency in SNPs of COVID-19 patients with age and gender. Materials and Methods: In our study, 200 patients with moderate COVID-19 were included. Single nucleotide polymorphisms (SNP) of TLR3 (rs3775291, rs3775290, rs5743305), TLR7 (rs179008), TLR8 (rs3764880), RIG-I (rs12006123), and CCR5 (rs1799987) were studied. SNPs were determined by restriction fragment length polymerase chain reaction (RFLP-PCR) methods. Results: In the COVID-19 patients, we examined the patients were evaluated in terms of allele and genotype frequencies and the association between some parameters like age, and gender. In our results, TLR3 rs5743305 AA genotype frequency (p=0.03) and TLR7 rs179008 AA genotype frequency (p=0.03) were found to be significant in terms of age and gender. Conclusions: These SNP data is assessed against disease risk to plan personalized pharmacological therapy for COVID-19 patients.The findings from this study will be useful for genome-wide association studies (GWAS).

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The investigation of host genetic variants of toll-like receptor 7 and 8 in COVID-19

Cited by 3 publications

References 42 publications

Relationship of Toll-Like Receptor 7, 9, and 10 Polymorphisms and the Severity of Coronavirus Disease 2019

Relationship of Toll-Like Receptor 7, 9, and 10 Polymorphisms and the Severity of Coronavirus Disease 2019

Toll-like receptors polymorphisms and COVID-19: a systematic review

Association of Several Innate Immune Response Gene Polymorphisms with COVID-19 in Turkish Population

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