The investigation of the efficacy ratio of cress seeds supplementation to moderate hyperglycemia and hepatotoxicity in streptozotocin‐induced diabetic rats

Doghmane, A.; Aouacheri, O.; Laouaichia, R.; Saka, S.

doi:10.1007/s40200-021-00764-9

Cited by 5 publications

(6 citation statements)

References 57 publications

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“…Finally, lipid peroxidation results in significant membrane injury and dysfunction [ 44 ]. Pharmacological treatment could help prevent diabetes complications by lowering lipid peroxidation and improving antioxidant status [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…The livers of diabetic rats treated with STZ have necrotized. The increased activities of AST and ALT in plasma could be attributed to the leakage of these enzymes from the liver cytosol into the bloodstream, indicating that STZ has a hepatotoxic effect [ 45 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…High food consumption and declining body weight were observed in STZ-induced diabetic rats, indicating polyphagia and the weight loss due to extreme breakdown of tissue proteins [ 45 , 52 ], as well as reduced function due to glucotoxicity [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Pwaniyibo et al [ 41 ] claim that the oral glucose tolerance of methanol F. perifolia leaves improved after 28 days of STZ in the animal models. As regards [ 45 ], it was revealed that cress seeds (CS) or L. sativum seeds alleviate hyperglycemia and oxidative stress damage in hyperglycemic rats.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the Efficiency of Lepidium sativum, Ficus carica, and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diabetic Rats

Ramadan

Hegab

Al-Awthan

et al. 2021

Journal of Diabetes Research

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Background. Diabetes mellitus (DM) is a metabolic disorder characterized by high blood glucose levels that occurs either due to insufficient insulin production or mounting resistance to its action. The purpose of this study was to investigate if methanolic extracts of Lepidium sativum seeds, Ficus carica, and Punica granatum leaves had any effect on blood sugar levels in normal and streptozotocin (STZ) diabetic rats, as well as to explore the most effective extract. Method. Healthy male albino rats weighing 185-266 g were divided into nine groups of eight rats each: normal control, diabetic control, diabetic rats with dietary supplements of L. sativum, F. carica, and P. granatum methanolic extracts, and diabetics treated with insulin. All of the rats were fed on ordinary diet with nutritional pellets and were given water ad libitum. To induce diabetes, all animals were administered with STZ intraperitoneal injection at a dose of 60 mg/kg body weight. For five weeks, the crude plant extracts were given orally to various groups of rats at doses of one hundred and two hundred mg/kg body weight. After that, animal groups were sacrificed and blood samples were taken. Results. Phytochemical analysis revealed that the highest amounts of polyphenolic compounds were present in L. sativum seeds and P. granatum leaves, while leaves of F. carica showed the highest amounts of alkaloid and flavonoid content compared to other extracts. Oral administration of F. carica and L. sativum extracts at the dosage of 100 and 200 mg/kg significantly reduced glucose, lipid profile, kidney, and liver enzyme levels. A significant increase in HbAlc levels was also observed with L. sativum extract at a dose of 200 mg/kg compared to diabetic controls. Mellitus rats supplemented with 100 and 200 mg/kg methanolic extracts of P. granatum had higher serum triglycerides and lower serum low-density lipoprotein cholesterol (LDL-C) than normal control rats. F. carica extract is more effective than L. sativum and P. granatum extracts in the prevention and control of type 2 diabetes mellitus (T2DM) and its consequences.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of the Efficiency of Lepidium sativum, Ficus carica, and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diabetic Rats

Ramadan

Hegab

Al-Awthan

et al. 2021

Journal of Diabetes Research

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“…Anti-diabetic activity 2.1 The ability of garden cress seeds (Lepidium sativum) to control blood sugar levels and lessen the signs and symptoms of diabetes has sparked interest in its anti-diabetic properties. Numerous research has looked into the bioactive substances found in these seeds and how they affect insulin sensitivity and glucose metabolism (Doghmane et al, 2021) [13] . An overview of garden cress seeds' anti-diabetic qualities is shown below 1.…”

Section: Support For Detoxificationmentioning

confidence: 99%

Exploring the versatile potential of garden cress seeds: Therapeutic applications and industrial utilization: A comprehensive review

Bhatia,

Bhasin

2023

Pharma Innovation

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The seeds of Lepidium sativum, commonly known as Garden Cress is an iron rich underutilized edible crop. Garden cress seeds have a variety of therapeutic properties, including antioxidants properties, antianemic properties, anti-diabetic properties, anti-inflammatory properties, hepatoprotective properties, antibacterial properties and chemoprotective properties. It may also be used in food supplementation to develop functional foods. Garden cress seeds have been utilized as medicine since ancient times. It is also used to treat conditions such as asthma, diarrhea, and numerous skin problems such as scurvy. However, it can also help to increase the milk supply in lactating mothers. Garden cress seeds have a high calcium, iron, folic acid, vitamin A, and vitamin C content. While, the seeds serve as a significant energy source due to high content of protein and fat. Also, these seeds are in use within the pharmaceutical, cosmetic industry and aroma therapy due to the presence of fatty acids, antioxidants and bioactive compounds in abundance. The current review is planned to give an overview about the functional, pharmacological properties and industrial uses of garden cress seeds to enhance the scope of this underutilized crop for human consumption.

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Nutritional composition, nutraceutical aspects, and medicinal benefits of garden cress (Lepidium sativum) seeds – A geographical and processing perspective

Kumar,

Singh

2024

Trends in Food Science & Technology

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The investigation of the efficacy ratio of cress seeds supplementation to moderate hyperglycemia and hepatotoxicity in streptozotocin‐induced diabetic rats

Cited by 5 publications

References 57 publications

Comparison of the Efficiency of Lepidium sativum, Ficus carica, and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diabetic Rats

Comparison of the Efficiency of Lepidium sativum, Ficus carica, and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diabetic Rats

Exploring the versatile potential of garden cress seeds: Therapeutic applications and industrial utilization: A comprehensive review

Nutritional composition, nutraceutical aspects, and medicinal benefits of garden cress (Lepidium sativum) seeds – A geographical and processing perspective

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