The investigation of the role of sirtuin-1 on embryo implantation in oxidative stress–induced mice

Aksu, Kubra; Golal, Ezgi; Aslan, Mutay; Üstünel, İ̇smail; Acar, Nuray

doi:10.1007/s10815-021-02229-7

Cited by 6 publications

(4 citation statements)

References 65 publications

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“…In porcine embryos, SIRT1 activation has proven to have a positive effect on the blastocyst formation rate [ 43 ]. Aksu et al (2021) found that SIRT1 may protect the embryo from oxidative stress during implantation through FoxO1 - SOD signaling [ 44 ]. SIRT7 is an essential factor in the determination of oocyte quality, as SIRT7 -depleted oocytes generate aneuploid eggs and their reactive oxygen levels are elevated, thereby compromising the developmental competence of the oocytes [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Detecting Embryo Developmental Potential by Single Blastomere RNA-Seq

Nõmm

Ivask

Pärn

et al. 2023

Genes

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Recent advances in preimplantation embryo diagnostics enable a wide range of applications using single cell biopsy and molecular-based selection techniques without compromising embryo production. This study was conducted to develop a single cell embryo biopsy technique and gene expression analysis method with a very low input volume to ensure normal embryo development and to see if there are differences in gene expression profiles between day-5 biopsied bovine embryos that developed into blastocysts and embryos arrested at morula stage. Out of the 65 biopsied morulae, 32 developed to blastocysts (49.2%). Out of the 13580 successfully annotated genes, 1204 showed a difference in mRNA expression level. Out of these, 155 genes were expressed in embryos developing to blastocysts. The pathway enrichment analysis revealed significant enrichment in “organelle biogenesis and maintenance”, “mRNA splicing” and “mitochondrial translation” pathways. These findings suggest principal differences in gene expression patterns and functional networks of embryos able to reach the blastocyst stage compared to embryos arrested in development. Our preliminary data suggest that single blastomere biopsy and selected gene expression profiles at morula stage could offer additional possibilities for early preimplantation embryo selection before transfer.

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Section: Discussionmentioning

confidence: 99%

Detecting Embryo Developmental Potential by Single Blastomere RNA-Seq

Nõmm

Ivask

Pärn

et al. 2023

Genes

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“…Therefore, there are well-documented reasons to treat the activation or inhibition of SIRT1 as a potential therapeutic target, especially in hypertensive disorders complicating pregnancy, in which the main pathomechanism is based on endothelial dysfunction [5,7,8,193]. This is even more important as the incidence of PE increases, possibly as a result of increased prevalence of predisposing disorders, such as chronic hypertension, diabetes, and obesity [194,195]…”

Section: Discussionmentioning

confidence: 99%

The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta

Wątroba,

Szewczyk,

Szukiewicz

2023

IJMS

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Sirtuins, especially SIRT1, play a significant role in regulating inflammatory response, autophagy, and cell response to oxidative stress. Since their discovery, sirtuins have been regarded as anti-ageing and longevity-promoting enzymes. Sirtuin-regulated processes seem to participate in the most prevalent placental pathologies, such as pre-eclampsia. Furthermore, more and more research studies indicate that SIRT1 may prevent pre-eclampsia development or at least alleviate its manifestations. Having considered this, we reviewed recent studies on the role of sirtuins, especially SIRT1, in processes determining normal or abnormal development and functioning of the placenta.

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“…ROS are mainly produced from mitochondrial metabolism through oxidative phosphorylation in human and mouse embryos [27]. The disturbed redox balance has been evidenced to inhibit embryo implantation through Sirt1-FoxO1-SOD signaling [28]. Furthermore, it should be noted that implantation and early pregnancy are pro-inflammatory states, as evidenced by the high levels of pro-inflammatory cytokines recorded during this phase [29].…”

Section: Discussionmentioning

confidence: 99%

Chenodeoxycholic Acid Improves Embryo Implantation and Metabolic Health through Modulating Gut Microbiota–Host Metabolites Interaction during Early Pregnancy

Chen,

Zhao,

et al. 2023

Antioxidants

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Fetus loss in early pregnancy is of major concern to both humans and animals, and this issue is largely influenced by embryo implantation. Chenodeoxycholic acid (CDCA), a primary bile acid, contributes to metabolic improvements and protects against intrahepatic cholestasis of pregnancy. However, the effect of CDCA on embryo implantation during early pregnancy has not been investigated. The present study demonstrated that CDCA administration during early pregnancy improved embryo implantation in sows and rats, thereby improving the pregnancy outcomes of sows. CDCA significantly reduced inflammation, oxidative stress, and insulin resistance. The metabolomics analysis indicated significant differences in the fecal metabolome, especially regarding the level of secondary bile acids, between the control and CDCA-treated sows. CDCA also influenced the serum metabolite profiles in sows, and the serum L-Histidine level was significantly correlated with the abundance of 19 differential fecal metabolites. Importantly, L-Histidine administration improved embryo implantation and metabolic health in rats during early pregnancy. Moreover, CDCA administration during early pregnancy also led to long-term metabolic improvements in sows. Our data indicated that CDCA improved embryo implantation by alleviating inflammation and oxidative stress, improving insulin sensitivity, and modulating the interaction between the gut microbiota and host metabolites. Therefore, CDCA intervention is a potential therapeutic strategy regarding embryo loss during pregnancy.

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The investigation of the role of sirtuin-1 on embryo implantation in oxidative stress–induced mice

Cited by 6 publications

References 65 publications

Detecting Embryo Developmental Potential by Single Blastomere RNA-Seq

Detecting Embryo Developmental Potential by Single Blastomere RNA-Seq

The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta

Chenodeoxycholic Acid Improves Embryo Implantation and Metabolic Health through Modulating Gut Microbiota–Host Metabolites Interaction during Early Pregnancy

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