The investigation of unique water-soluble heptamethine cyanine dye for use as NIR photosensitizer in photodynamic therapy of cancer cells

Yang, Xin; Bai, Jin; Qian, Ying

doi:10.1016/j.saa.2019.117702

Cited by 33 publications

(23 citation statements)

References 36 publications

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“…For example, iodination on the heterocyclic core in heptamethine cyanine increases the ISC efficiency through heavy-atom effect with resulting cultivated therapeutic efficacy ( Shi et al, 2016 ; Huang and Luo, 2020 ). On the other hand, it is also possible to achieve high singlet oxygen yield with heavy-atom–free cyanine conjugates by incorporating them with an ISC-promoting moiety such as tetramethylpiperidinyloxy (TEMPO) ( Yang et al, 2020 ).…”

Section: Cyanine Dyes In Phototherapiesmentioning

confidence: 99%

Recent Advances in Cyanine-Based Phototherapy Agents

et al. 2021

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Phototherapies, in the form of photodynamic therapy (PDT) and photothermal therapy (PTT), are very promising treatment modalities for cancer since they provide locality and turn-on mechanism for toxicity, both of which are critical in reducing off-site toxicity. Irradiation of photosensitive agents demonstrated successful therapeutic outcomes; however, each approach has its limitations and needs to be improved for clinical success. The combination of PTT and PDT may work in a synergistic way to overcome the limitations of each method and indeed improve the treatment efficacy. The development of single photosensitive agents capable of inducing both PDT and PTT is, therefore, extremely advantageous and highly desired. Cyanine dyes are shown to have such potential, hence have been very popular in the recent years. Luminescence of cyanine dyes renders them as phototheranostic molecules, reporting the localization of the photosensitive agent prior to irradiation to induce phototoxicity, hence allowing image-guided phototherapy. In this review, we mainly focus on the cyanine dye–based phototherapy of different cancer cells, concentrating on the advancements achieved in the last ten years.

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Section: Cyanine Dyes In Phototherapiesmentioning

confidence: 99%

Recent Advances in Cyanine-Based Phototherapy Agents

et al. 2021

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“…In addition, several other fluorescent compounds even suggest their potentials as novel anti-CSC agents [19,20]. For these fluorescent dyes, simultaneous cancer targeting, imaging, and cancer killing are a major advantage for cancer biology research and are expected to contribute to the future cancer therapy directions including photodynamic therapy (PDT) [21][22][23]. Furthermore, several specific membrane molecules targeting cancer cells have already been used in the in vivo NIR photoimmunotherapy field [24].…”

Section: Introductionmentioning

confidence: 99%

A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production

Zhang

Liu

Bai

et al. 2021

Bioinorganic Chemistry and Applications

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Development of multiple agents has a significant impact on the cancer diagnosis and therapy. Several fluorescent dyes including near-infrared (NIR) fluorescent agents have been already well studied in the field of photodynamic therapy (PDT). In the present study, we reported a novel fluorescent dye could obviously inhibit cancer cell proliferation with slight toxic effects on the biological organism. Furthermore, it displayed selective staining on cancer cells, particularly on cancer stem cells (CSCs), rather than normal cells. Mechanically, this dye preferred to invading mitochondria of cancer cells and inducing overwhelming reactive oxygen species (ROS) production. The in vivo experiments further demonstrated that this dye could image cancer cells and even CSCs in a short-time intratumor injection manner using a zebrafish model and subsequently inhibit cancer cell proliferation after a relatively long-time drug exposure. Taken together, the future development of this agent will promise to make an essential contribution to the cancer diagnosis and therapeutics.

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“…By contrast, a heavy-atom-free cyanine conjugate ( 18 ) with exceptional singlet oxygen yield, reaching 0.1696 compared to 0.008 of ICG, was recently developed by conjugating with ISC-promoting moiety ( Fig. 7 A) [ 45 ]. Other common limiting factors include short circulation half-life and poor water solubility [ 8 ]; encouragingly, numerous research have been dedicated to address these concerns by integrating nanoplatform into these cyanine conjugates ( Fig.…”

Section: Phototherapymentioning

confidence: 99%

Cyanine conjugates in cancer theranostics

Yang

Zhou

Yue

et al. 2021

Bioactive Materials

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Cyanine is a meritorious fluorogenic core for the construction of fluorescent probes and its phototherapeutic potential has been enthusiastically explored as well. Alternatively, the covalent conjugation of cyanine with other potent therapeutic agents not only boosts its therapeutic efficacy but also broadens its therapeutic modality. Herein, we summarize miscellaneous cyanine–therapeutic agent conjugates in cancer theranostics from literature published between 2014 and 2020. The application scenarios of such theranostic cyanine conjugates covered common cancer therapeutic modalities, including chemotherapy, phototherapy and targeted therapy. Besides, cyanine conjugates that serve as nanocarriers for drug delivery are introduced as well. In an additional section, we analyze the potential of these conjugates for clinical translation. Overall, this review is aimed to stimulate research interest in exploring unattempted therapeutic agents and novel conjugation strategies and hopefully, accelerate clinical translation in this field.

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The investigation of unique water-soluble heptamethine cyanine dye for use as NIR photosensitizer in photodynamic therapy of cancer cells

Cited by 33 publications

References 36 publications

Recent Advances in Cyanine-Based Phototherapy Agents

Recent Advances in Cyanine-Based Phototherapy Agents

A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production

Cyanine conjugates in cancer theranostics

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