The investigation of volatile organic compounds in diagnosing (early) esophageal squamous cell carcinoma and gastric adenocarcinoma

Yang, Hang; Xiang, Chengfang; Mou, Yi; Zhou, Xinyue; Li, Wenwen; Duan, Yixiang; Hu, Bing

doi:10.1007/s00432-023-04595-4

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…It was initially proposed by Williams and Pembroke in 1989 [70]. Since then, various original reports and commentaries have been published detailing the olfactory identification of various types of cancer, including PCa [18,31,34,37,38,[71][72][73][74][75][76][77][78][79][80]. Dogs possess an incredibly sense of smell, with the ability to detect concentrations as low as one part per trillion (ppt).…”

Section: Discussionmentioning

confidence: 99%

“…The analysis of volatile organic compounds (VOCs) and volatile organic metabolites (VOMs) has emerged as a new frontier for cancer diagnosis in particular because it is non-invasive and potentially inexpensive (Figure 1) [9][10][11][12][13][14][15][16]. The concept has been demonstrated with different types of cancer [10,[16][17][18][19][20][21]. VOCs typically originate from primary or secondary metabolic processes and are characterized by their lipophilic molecular nature.…”

Section: Introductionmentioning

confidence: 99%

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Early Detection of Prostate Cancer: The Role of Scent

et al. 2023

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Prostate cancer (PCa) represents the cause of the second highest number of cancer-related deaths worldwide, and its clinical presentation can range from slow-growing to rapidly spreading metastatic disease. As the characteristics of most cases of PCa remains incompletely understood, it is crucial to identify new biomarkers that can aid in early detection. Despite the prostate-specific antigen serum (PSA) levels, prostate biopsy, and imaging representing the actual gold-standard for diagnosing PCa, analyzing volatile organic compounds (VOCs) has emerged as a promising new frontier. We and other authors have reported that highly trained dogs can recognize specific VOCs associated with PCa with high accuracy. However, using dogs in clinical practice has several limitations. To exploit the potential of VOCs, an electronic nose (eNose) that mimics the dog olfactory system and can potentially be used in clinical practice was designed. To explore the eNose as an alternative to dogs in diagnosing PCa, we conducted a systematic literature review and meta-analysis of available studies. PRISMA guidelines were used for the identification, screening, eligibility, and selection process. We included six studies that employed trained dogs and found that the pooled diagnostic sensitivity was 0.87 (95% CI 0.86–0.89; I2, 98.6%), the diagnostic specificity was 0.83 (95% CI 0.80–0.85; I2, 98.1%), and the area under the summary receiver operating characteristic curve (sROC) was 0.64 (standard error, 0.25). We also analyzed five studies that used an eNose to diagnose PCa and found that the pooled diagnostic sensitivity was 0.84 (95% CI, 0.80–0.88; I2, 57.1%), the diagnostic specificity was 0.88 (95% CI, 0.84–0.91; I2, 66%), and the area under the sROC was 0.93 (standard error, 0.03). These pooled results suggest that while highly trained dogs have the potentiality to diagnose PCa, the ability is primarily related to olfactory physiology and training methodology. The adoption of advanced analytical techniques, such as eNose, poses a significant challenge in the field of clinical practice due to their growing effectiveness. Nevertheless, the presence of limitations and the requirement for meticulous study design continue to present challenges when employing eNoses for the diagnosis of PCa.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Early Detection of Prostate Cancer: The Role of Scent

et al. 2023

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What Do We Know About Capsicum Volatilome?

Ithaí Ángeles‐López,

José Martínez‐Cano,

Villa‐Ruano

2024

Chemistry & Biodiversity

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The Capsicum genus includes several cultivated species that release complex blends of volatile organic compounds (VOCs) associated with their unique aroma. These VOCs are essential info‐chemicals in ecological interactions. In this review, we describe how the volatilomic profiling naturally varies based on specific plant organs and genotypes as well as how non‐beneficial organisms affect VOCs biosynthesis and accumulation in pepper plants. Also, we show evidence about VOCs variation under the pressure of different abiotic factors such as water stress, soil type and nutrient availability. The contribution of specific metabolic pathways and gene expression related to the biosynthesis of particular VOCs is addressed. We highlighted the utility of VOCs as chemical markers for quality control in the food industry, breeding programs to generate resistant plants and to improve aroma innovation. Herein we present a database containing 2734 VOCs, revealing 113 as the basic core of the volatilome from five Capsicum species.

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The investigation of volatile organic compounds in diagnosing (early) esophageal squamous cell carcinoma and gastric adenocarcinoma

Cited by 2 publications

References 17 publications

Early Detection of Prostate Cancer: The Role of Scent

Early Detection of Prostate Cancer: The Role of Scent

What Do We Know About Capsicum Volatilome?

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