2023
DOI: 10.3390/ijms25010549
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The Involvement of LAG-3positive Plasma Cells in the Development of Multiple Myeloma

Natalia Kreiniz,
Nasren Eiza,
Tamar Tadmor
et al.

Abstract: The Lymphocyte-Activation Protein 3 (LAG-3) inhibitory receptor is expressed on regulatory plasma cells (PCs). Micro-environmental cells that express LAG-3 were found to be increased during the progression of smoldering multiple myeloma (SMM). To assess the possible role of LAG-3 expression on regulatory PCs in patients with plasma cell dyscrasia. Purified Cluster of Differentiation 138 (CD138+) PCs from patients with premalignant conditions, active multiple myeloma (MM), and controls were analyzed for the exp… Show more

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