The involvement of left inferior frontal and middle temporal cortices in word production unveiled by greater facilitation effects following brain damage

Python, Grégoire; Glize, Bertrand; Laganaro, Marina

doi:10.1016/j.neuropsychologia.2018.10.026

Cited by 31 publications

(18 citation statements)

References 73 publications

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“…Involvement of mid-to-posterior superior temporal (STG) and middle temporal (MTG) gyri has been reported, with effects sometimes going in opposite directions [14][15][16][17]. Patients with lesions in the temporal lobe, overlapping in the mid-to-posterior MTG, may sometimes show increased semantic interference effects [18,19]. In a neuroimaging study focusing on control demands across verbal and non-verbal tasks, cross-domain activity was found in the mid-to-posterior STG for the most difficult conditions [for picture-word interference, the categorically related condition ; 20].…”

Section: Introductionmentioning

confidence: 99%

Effects of transcranial magnetic stimulation over the left posterior superior temporal gyrus on picture-word interference

2020

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Word-production theories argue that during language production, a concept activates multiple lexical candidates in left temporal cortex, and the intended word is selected from this set. Evidence for theories on spoken-word production comes, for example, from the picture-word interference task, where participants name pictures superimposed by congruent (e.g., picture: rabbit, distractor “rabbit”), categorically related (e.g., distractor “sheep”), or unrelated (e.g., distractor “fork”) words. Typically, whereas congruent distractors facilitate naming, related distractors slow down picture naming relative to unrelated distractors, resulting in semantic interference. However, the neural correlates of semantic interference are debated. Previous neuroimaging studies have shown that the left mid-to-posterior STG (pSTG) is involved in the interference associated with semantically related distractors. To probe the functional relevance of this area, we targeted the left pSTG with focal repetitive transcranial magnetic stimulation (rTMS) while subjects performed a picture-word interference task. Unexpectedly, pSTG stimulation did not affect the semantic interference effect but selectively increased the congruency effect (i.e., faster naming with congruent distractors). The facilitatory TMS effect selectively occurred in the more difficult list with an overall lower name agreement. Our study adds new evidence to the causal role of the left pSTG in the interaction between picture and distractor representations or processing streams, only partly supporting previous neuroimaging studies. Moreover, the observed unexpected condition-specific facilitatory rTMS effect argues for an interaction of the task- or stimulus-induced brain state with the modulatory TMS effect. These issues should be systematically addressed in future rTMS studies on language production.

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Section: Introductionmentioning

confidence: 99%

Effects of transcranial magnetic stimulation over the left posterior superior temporal gyrus on picture-word interference

2020

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“…After IM-FTP, functional modification in the left frontal inferior cortex was observed, which we interpreted as both plastic adjustment and compensatory effect [ 38 ]. The left inferior frontal gyrus, in close relationship with the left posterior middle temporal gyrus, plays an essential role in syntactic analysis [ 39 ] and lexical selection [ 40 ], and is one of the areas stimulated during training with IM-FTP.…”

Section: Discussionmentioning

confidence: 99%

Feasibility Randomized Trial for an Intensive Memory-Focused Training Program for School-Aged Children with Acquired Brain Injury

et al. 2020

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(1) Background: Memory deficits are common sequelae of pediatric Acquired Brain Injury (ABI). Only methods for non-focused cognitive remediation are available to the pediatric field. The aims of this feasibility trial are the description, implementation, and test of an intensive program specific to the training and re-adaptation of memory function in children, called Intensive Memory-Focused Training Program (IM-FTP); (2) Methods: Eleven children and adolescents with ABI (mean age at injury = 12.2 years, brain tumor survivors excluded) were clinically assessed and rehabilitated over 1-month through IM-FTP, including physio-kinesis/occupational, speech, and neuropsychology treatments. Each patient received a psychometric evaluation and a brain functional MRI at enrollment and at discharge. Ten pediatric controls with ABI (mean age at injury = 13.8 years) were clinically assessed, and rehabilitated through a standard program; (3) Results: After treatment, both groups had marked improvement in both immediate and delayed recall. IM-FTP was associated with better learning of semantically related and unrelated words, and larger improvement in immediate recall in prose memory. Imaging showed functional modification in the left frontal inferior cortex; (4) Conclusions: We described an age-independent reproducible multidisciplinary memory-focused rehabilitation protocol, which can be adapted to single patients while preserving inter-subject comparability, and is applicable up to a few months after injury. IM-FTP will now be employed in a powered clinical trial.

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“…By contrast, activity in frontal cortex is commonly interpreted as a control mechanism operating over lexico-semantic representations (Badre et al, 2005;Piai et al, 2014;Wagner, Paré-Blagoev, Clark, & Poldrack, 2001). However the contribution of left IFG in the resolution of lexico-semantic competition still remains elusive (de Zubicaray, Hansen, & McMahon, 2013;Piai & Knight, 2018;Piai et al, 2016;Piai, Roelofs, Acheson, & Takashima, 2013;Python, Glize, & Laganaro, 2018). It is of importance to note that most of these studies address competitive word production.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, previous studies investigating the role of left prefrontal cortex (PFC) in word selection showed that left PFC helps overcome semantic interference by boosting mechanisms of control (Ries et al, 2014), especially when selection demands are difficult . However, PFC involvement may be dependent on the task and individual variability (Piai & Knight, 2018;Piai, Ries, & Swick, 2016;Python et al, 2018). Recently, it has been proposed that prefrontal regions, in particular the inferior frontal gyrus (IFG), operate in conjunction with the posterior middle temporal gyrus (MTG) contributing to the mechanisms of semantic control (Davey et al, 2016;Carin Whitney, Kirk, O'Sullivan, Lambon Ralph, & Jefferies, 2012).…”

Section: Introductionmentioning

confidence: 99%

Lexical-semantic and executive deficits revealed by computational modelling: a drift diffusion model perspective

Todorova¹,

Neville²,

Piai³

2019

Preprint

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Flexible language use requires coordinated functioning of two systems: conceptual representations and control. The interaction between two systems can be observed when people are asked to match a word to a picture. Participants are slower and less accurate for related word-picture pairs (word: banana, picture: apple) relative to unrelated pairs (word: banjo, picture: apple). The mechanism underlying interference however is still unclear. We analyzed word-picture verification (WPM) performance of patients with stroke-induced lesions to the left-temporal (N = 5) or left-frontal cortex (N = 5) and matched controls (N = 12) using the drift diffusion model (DDM). In DDM the process of making a decision is described as the stochastic accumulation of evidence towards a response. The parameters of the DDM model that characterize this process are decision threshold, drift rate, starting point and non-decision time. Each of them bears cognitive interpretability and we compared the estimated model parameters from controls and patients to investigate the mechanisms of WPM interference. WPM performance in controls was explained by the amount of information needed to make a decision (decision threshold): a higher threshold was associated with related word-picture pairs relative to unrelated ones. No difference was found in the quality of the evidence (drift rate). This suggests an executive rather than semantic mechanism underlying WPM interference. Both patients with temporal and frontal lesions exhibited both increased drift rate and decision threshold for unrelated pairs relative to related ones. Left-frontal and temporal damage affected the computations required by WPM similarly, resulting in systematic deficits across lexical-semantic memory and executive functions. These results support a diverse but interactive role of lexical-semantic memory and semantic control mechanisms.

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The involvement of left inferior frontal and middle temporal cortices in word production unveiled by greater facilitation effects following brain damage

Cited by 31 publications

References 73 publications

Effects of transcranial magnetic stimulation over the left posterior superior temporal gyrus on picture-word interference

Effects of transcranial magnetic stimulation over the left posterior superior temporal gyrus on picture-word interference

Feasibility Randomized Trial for an Intensive Memory-Focused Training Program for School-Aged Children with Acquired Brain Injury

Lexical-semantic and executive deficits revealed by computational modelling: a drift diffusion model perspective

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