The involvement of magnoflorine in the sedative and anxiolytic effects of Sinomeni Caulis et Rhizoma in mice

Peña, June Bryan de la; Lee, Hye Lim; Yoon, Seo Young; Kim, Chan Yun; Lee, Yong Soo; Cheong, Jae Hoon

doi:10.1007/s11418-013-0754-3

Cited by 38 publications

(13 citation statements)

References 28 publications

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“…P. Fernandez et al, 2008;Flores et al, 2006;Fortes et al, 2013;Fraser et al, 2010;Frassetto et al, 2010;Galeotti et al, 2013;Girish et al, 2013;Gomes et al, 2010;Ma Eva Gonzalez-Trujano et al, 2006;Maria Eva Gonzalez-Trujano et al, 2015;González-Pardo et al, 2006;Griebel et al, 1998;1999a;1999b;Guilloux et al, 2013;Gupta et al, 2014;Han et al, 2009;Harada et al, 2006;Hasenohrl et al, 1996;Hazim et al, 2014;Huerta-Reyes et al, 2013;Hui et al, 2002;Ishaq, 2014;N. S. Jain et al, 2005;Jastrzebska-Wiesek et al, 2014;Jászberényi et al, 2009;Jessa et al, 1996;Jones et al, 1994;Kalouda and Pitsikas, 2015;Karakas et al, 2011;Karim et al, 2011;Kebebew and Shibeshi, 2013;Klodzinska et al, 2004a;2004b;Kong et al, 2006;Kumar and Bhat, 2014;Kurhe et al, 2014;Kuribara et al, 2000;la Pena et al, 2013;LaBuda and Fuchs, 2001;Langen et al, 2005;Leggio et al,...…”

Section: Summary Measuresunclassified

Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses

Mohammad

Ho²,

Lim

et al. 2015

Preprint

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Rodent defense behavior assays have been widely used as preclinical models of anxiety to study possibly therapeutic anxiety-reducing interventions. However, some proposed anxiety-modulating factors-genes, drugs and stressors-have had discordant effects across different studies. To reconcile the effect sizes of purported anxiety factors, we conducted systematic review and meta-analyses of the literature on ten anxiety-linked interventions, as examined in the elevated plus maze, open field and light-dark box assays. Diazepam, 5-HT1A receptor gene knockout and overexpression, SERT gene knockout and overexpression, pain, restraint, social isolation, corticotropin-releasing hormone and Crhr1 were selected for review. Eight interventions had statistically significant effects on rodent anxiety, while Htr1a overexpression and Crh knockout did not. Evidence for publication bias was found in the diazepam, Htt knockout, and social isolation literatures. The Htr1a and Crhr1 results indicate a disconnect between preclinical science and clinical research. Furthermore, the meta-analytic data confirmed that genetic SERT anxiety effects were paradoxical in the context of the clinical use of SERT inhibitors to reduce anxiety.

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Section: Summary Measuresunclassified

Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses

Mohammad

Ho²,

Lim

et al. 2015

Preprint

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“…Magnoflorine is an important kind of aporphine alkaloid that exists in many herbs, including Berberidaceae, Euphorbiaceae (Dwumabadu et al, 1980), Magnoliaceae (Mohamed et al, 2010) and Ranunculaceae (Chen et al, 2009). Modern pharmacological studies have shown that magnoflorine has a variety of pharmacological and biological effects, including antifungal activities (Chen et al, 2009), antioxidation (Hung et al, 2007a(Hung et al, , 2007bHisatomi et al, 2000), anti-inflammation (Sharma et al, 2012;Küpeli et al, 2002), sedative, anxiolytic (de la Peña et al, 2013) and antidiabetic activities (Patel and Mishra, 2011, 2012a, 2012bChen et al, 2012). Recently, considerable attention has been focused on its antidiabetic effects with the purpose of developing magnoflorine as a potential agent.…”

Section: Introductionmentioning

confidence: 99%

“…The most representative of aporphine alkaloids is apomorphine (Hattori and Nomoto, 2014;Bogucki, 2013), which is a well established treatment for the management of sudden, unexpected and refractory levodopa-induced 'off' states in fluctuating Parkinson's disease. Studies have also shown magnoflorine to have sedative and anxiolytic effects (de la Peña et al, 2013). This suggests that magnoflorine has pharmacological activities acting on the brain and playing a considerable role that cannot be ignored in Coptidis Rhizoma.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo identification of metabolites of magnoflorine by LC LTQ‐Orbitrap MS and its potential pharmacokinetic interaction in Coptidis Rhizoma decoction in rat

Xue

Zhao

Miao

et al. 2015

Biomedical Chromatography

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Magnoflorine, an important aporphine alkaloid in Coptidis Rhizoma, is increasingly attracting research attention because of its pharmacological activities. The in vivo and in vitro metabolism of magnoflorine was investigated by LC LTQOrbitrap MS. In vivo samples including rat urine, feces, plasma and bile were collected separately after both oral (50 mg kg À1 ) and intravenous administration (10 mg kg À1 ) of magnoflorine, along with in vitro samples prepared by incubating magnoflorine with rat intestinal flora and liver microsome. As a result, 12 metabolites were found in biological samples. Phase I metabolites were identified in all biological samples, while phase II metabolites were mainly detected in urine, plasma and bile. In a pharmacokinetic study, rats were not only dosed with magnoflorine via oral (15, 30 and 60 mg kg À1 ) and intravenous administration (10 mg kg À1 ) but also dosed with Coptidis Rhizoma decoction (equivalent to 30 mg kg À1 of magnoflorine) by intragastric administration to investigate the interaction of magnoflorine with the rest of compounds in Coptidis Rhizoma. Studies showed that magnoflorine possessed lower bioavailability and faster absorption and elimination. However, pharmacokinetic parameters altered significantly (p < 0.05) when magnoflorine was administered in Coptidis Rhizoma decoction. Oral gavage of Coptidis Rhizoma decoction decreased the absorption and elimination rates of magnoflorine, which revealed that there existed pharmacokinetic interactions between magnoflorine and the rest of ingredients in Coptidis Rhizoma.

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“…Both N-methylcytisine [110] and anagyrine [534] have been shown to be teratogenic, however. The aporphine alkaloid magnoflorine, on the other hand, has shown sedative and anxiolytic effects [535] and may be responsible for the anti-convulsive and sedative uses of C. thalictroides in Cherokee traditional medicine.…”

Section: Caulophyllum Thalictroides (L) Michxmentioning

confidence: 99%

The Phytochemistry of Cherokee Aromatic Medicinal Plants

Setzer

2018

Medicines

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Background: Native Americans have had a rich ethnobotanical heritage for treating diseases, ailments, and injuries. Cherokee traditional medicine has provided numerous aromatic and medicinal plants that not only were used by the Cherokee people, but were also adopted for use by European settlers in North America. Methods: The aim of this review was to examine the Cherokee ethnobotanical literature and the published phytochemical investigations on Cherokee medicinal plants and to correlate phytochemical constituents with traditional uses and biological activities. Results: Several Cherokee medicinal plants are still in use today as herbal medicines, including, for example, yarrow (Achillea millefolium), black cohosh (Cimicifuga racemosa), American ginseng (Panax quinquefolius), and blue skullcap (Scutellaria lateriflora). This review presents a summary of the traditional uses, phytochemical constituents, and biological activities of Cherokee aromatic and medicinal plants. Conclusions: The list is not complete, however, as there is still much work needed in phytochemical investigation and pharmacological evaluation of many traditional herbal medicines.

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The involvement of magnoflorine in the sedative and anxiolytic effects of Sinomeni Caulis et Rhizoma in mice

Cited by 38 publications

References 28 publications

Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses

Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses

In vitro and in vivo identification of metabolites of magnoflorine by LC LTQ‐Orbitrap MS and its potential pharmacokinetic interaction in Coptidis Rhizoma decoction in rat

The Phytochemistry of Cherokee Aromatic Medicinal Plants

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