The involvement of nitric oxide in the anti-seizure effect of acute atorvastatin treatment in mice

Abstract

In conclusion, anti-convulsant effect of atorvastatin was demonstrated in two seizure models of electroshock and intraperitoneal pentylenetetrazole. Nitric oxide release, probably through inducible nitric oxide synthase at least in part is responsible for this effect.

A COX/5-LOX Inhibitor Licofelone Revealed Anticonvulsant Properties Through iNOS Diminution in Mice

“…However, there are some studies which have reported non-effect or even protective effects for iNOS activation in seizure susceptibility [25,29,59]. In contrast to our data, some investigators showed iNOS inhibition (by aminoguanidine) reversed the anticonvulsant effects of acute or chronic atorvastatine treatment in different seizure paradigms [59,60]. This difference could be due to the variation in type of seizure, source of NO, and other neurotransmitter systems involved in seizure susceptibility [61].…”

Statin treatment reduces the risk of poststroke seizures

“…In recent years, statins have been found to have neuroprotective effects in stroke 6 and are recommended as neuroprotective agents in acute stroke treatment. [8][9][10][11][12] However, no study has been conducted to investigate the effect of statins on the risk of poststroke seizures, even though statins are used widely in stroke patients. [8][9][10][11][12] However, no study has been conducted to investigate the effect of statins on the risk of poststroke seizures, even though statins are used widely in stroke patients.…”

Potential anti-seizure activity of atorvastatin in rat models of seizure

“…In addition to reducing the serum cholesterol levels, statins have various pleiotropic effects such as increasing nitric oxide (NO), reducing oxidative stress, neuroinflammation, and neurotoxicity. 3 Increasing evidence indicates that statins are neuroprotective in various conditions, including stroke, cerebral ischemia and traumatic brain injury. 3 As statins possess antioxidant, neuroprotective effects, they may be expected to possess antiepileptic activity too.…”

“…3 Increasing evidence indicates that statins are neuroprotective in various conditions, including stroke, cerebral ischemia and traumatic brain injury. 3 As statins possess antioxidant, neuroprotective effects, they may be expected to possess antiepileptic activity too. However, only scanty reports are available on anticonvulsant action of statins and in them some comprise controversial reports of atorvastatin on experimental seizure models.…”