The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test

Szewczyk, Bernadeta; Poleszak, Ewa; Właź, Piotr; Wróbel, Andrzej; Blicharska, Eliza; Cichy, Agnieszka; Dybała, Małgorzata; Siwek, Agata; Pomierny-Chamioło, Lucyna; Piotrowska, Anna; Brański, Piotr; Pilc, Andrzej; Nowak, Gabriel

doi:10.1016/j.pnpbp.2008.12.011

Cited by 119 publications

(99 citation statements)

References 44 publications

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“…The authors also observed an increase in the swimming, but not climbing parameter of the rat FST after zinc administration, which indicates involvement of the serotonin pathway [56]. Moreover, joint administration of zinc and fluoxetine, paroxetine, citalopram or bupropion (all in ineffective doses), yet not reboxetine, significantly decreased the immobility time in the FST and TST [10,56]. Furthermore, there is strong evidence also suggesting the involvement of the dopaminergic system in the antidepressant properties of zinc.…”

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 88%

“…However, these results are in disagreement with the finding of the involvement of the serotonergic and dopaminergic system in the antidepressant action of zinc. Szewczyk et al [56] showed that the antidepressant-like effect of zinc was significantly antagonized by pretreatment with an inhibitor of serotonin synthesis, p-chlorophenylalanine (pCPA), 5HT-2 A/C receptor antagonist, ritanserin or 5HT-1 A receptor antagonist, WAY 1006335. The authors also observed an increase in the swimming, but not climbing parameter of the rat FST after zinc administration, which indicates involvement of the serotonin pathway [56].…”

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 99%

“…Szewczyk et al [56] showed that the antidepressant-like effect of zinc was significantly antagonized by pretreatment with an inhibitor of serotonin synthesis, p-chlorophenylalanine (pCPA), 5HT-2 A/C receptor antagonist, ritanserin or 5HT-1 A receptor antagonist, WAY 1006335. The authors also observed an increase in the swimming, but not climbing parameter of the rat FST after zinc administration, which indicates involvement of the serotonin pathway [56]. Moreover, joint administration of zinc and fluoxetine, paroxetine, citalopram or bupropion (all in ineffective doses), yet not reboxetine, significantly decreased the immobility time in the FST and TST [10,56].…”

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 99%

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Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

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Abstract:Background: There is some evidence coming from preclinical and clinical studies suggesting a relationship between dietary zinc intake and depressive symptoms. The aim of the study was to determine whether zinc deficiency alters the response to antidepressants with a different mechanism of action. We examine also whether these changes are related to activity of the hypothalamic-pituitaryadrenal HPA axis. Methods: Male CD-1 mice were assigned to groups according to diet and antidepressant administration. To evaluate animal behavior, the immobility time in the forced swim test (FST) and locomotor activity were measured. To determine serum zinc levels the flame atomic absorption spectroscopy (FAAS) was used. The serum corticosterone was determined by radioimmunoassay (RIA). Results: Antidepressants administered to zinc-deprived mice induced an altered response in the FST when compared to animals fed with an adequate diet. There were no changes in locomotor activity. Animals subjected to a zinc-deficient diet showed a significant reduction in serum zinc levels, which was normalized by antidepressant treatment. An increase in serum corticosterone concentrations in mice fed with a zinc-deficient diet and treated with antidepressants was observed, so it can be concluded that reduced levels of zinc contribute hyperactivation of the HPA axis. Conclusion:The results of this study suggest that a diet with a reduced zinc level alters antidepressant action, which is associated with a reduction in the serum zinc level and rise in the corticosterone level. The results of this study may indicate the involvement of zinc deficiency in the pathogenesis of depression.

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Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 88%

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 99%

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 99%

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Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

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“…Based on the results of experiments examining the mechanism of zinc antidepressant-like activity, we can speculate that the anxiolytic activity of zinc (like organic NMDA receptor antagonists, e.g., [8,19]) may be related to its antagonism of NMDA and/or mGluR5 glutamate receptors [17 for review]. However, zinc action through GABA-ergic or serotonergic receptors cannot be disregarded [29]. Further studies are needed to evaluate the exact mechanism(s) responsible for the anxiolytic activity of zinc.…”

Section: Resultsmentioning

confidence: 99%

Anxiolytic-like activity of zinc in rodent tests

Partyka

Jastrzębska-Więsek

Szewczyk

et al. 2011

Pharmacological Reports

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Abstract:Because zinc deficiency induces depression and anxiety-like behavior in rodents, we examined the effects of zinc administration in several tests by measuring anxiolytic activity in mice and rats. We now report that zinc significantly increased the number of entries into the open arms in the elevated plus maze in rats. Moreover, zinc treatment significantly increased the number of punished crossings in the four-plate test and attenuated stress-induced hyperthermia (SIH) in mice. However, no effect of zinc administration was observed in the elevated plus maze test in mice. This lack of effect in the latter case was probably due to the substantial zinc-induced reduction in locomotor activity by the doses used in mice.The present data demonstrate for the first time the anxiolytic-like activity of zinc in rodents and may indicate that zinc could be used as a novel therapeutic/adjunct agent in anxiolytic therapy.

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“…Concentration of these elements can be related to such neurotransmitters as monoamine and serotonin (Ruljancic, Mihanovic, Cepelak, Bakliza, & Curkovic, 2013;Szewczyk et al, 2008;Szewczyk et al, 2009). Indeed, depression and anxiety relate to the dysfunction of brain glutamate system.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Zinc and Magnesium Serum Levels with Postpartum Depression in Tabriz-Iran

Edalati-Fard¹,

Mirghafourvand²,

Mohammad‐Alizadeh‐Charandabi³

et al. 2016

GJHS

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Objective: According to the World Health Organization, depression will be the second prevalent problem after ischemic heart diseases by the year 2020. Postpartum depression (PPD) as a major depressive episode has devastating impacts on the health of mother, newborn, infant, and even the whole family. This study was conducted to investigate the relationship of zinc and magnesium serum levels with PPD, as one of the commonly assumed causes of depression. Methods:This cross-sectional study was done on 122 postpartum women aged 18 years and more in two educational hospitals and one non-educational hospital in Tabriz-Iran, 2015. The eligible women were selected using convenience sampling method. Then, the demographic characteristics questionnaire and Edinburgh Depression Scale were completed by participants, and 5cc of blood sample was drawn from each participant. For data analysis, logistic regression test was used. Results:The mean score of depression scale was 8.0 (SD: 4.7), meaning that 18.9% of mothers were depressed. Results indicated a significant inverse correlation between Edinburgh depression score and magnesium serum level (p= 0.001). However, there was no statistically significant relationship between the zinc serum level and Edinburgh depression score (p=0.831), in so far as based on logistic regression analysis, increased magnesium serum level decreased the odds of depression [Odds ratio: 0.05; CI 95%: 0.01 to 0.29].Conclusions: In this study, there was a significant inverse relationship between magnesium serum level and Edinburgh depression score.

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The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test

Cited by 119 publications

References 44 publications

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Anxiolytic-like activity of zinc in rodent tests

Relationship of Zinc and Magnesium Serum Levels with Postpartum Depression in Tabriz-Iran

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