The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes

Sawa, Ran; Wake, Ikumi; Yamamoto, Yu; Okimura, Yasuhiko

doi:10.1016/j.ghir.2021.101406

Cited by 4 publications

(2 citation statements)

References 29 publications

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Section: Discussionmentioning

confidence: 99%

“…It is possible therefore that the thermally sensitive effects of BPA on metabolism and growth are mediated via these endocrine axes, which it is known to affect [69]. Investigating the mechanisms underlying the thermal dependence of BPA-mediated effects on hormone and growth signalling pathways [70,71] would be a promising future line of investigation. Anthropomorphic modification of environments can potentially reset the energetics of ecosystems because evolved responses to environmental change are not matched to novel anthropogenic signals.…”

Section: Discussionmentioning

confidence: 99%

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Endocrine disruption from plastic pollution and warming interact to increase the energetic cost of growth in a fish

Rubin

Seebacher

2022

Proc. R. Soc. B.

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Energetic cost of growth determines how much food-derived energy is needed to produce a given amount of new biomass and thereby influences energy transduction between trophic levels. Growth and development are regulated by hormones and are therefore sensitive to changes in temperature and environmental endocrine disruption. Here, we show that the endocrine disruptor bisphenol A (BPA) at an environmentally relevant concentration (10 µgl −1 ) decreased fish ( Danio rerio ) size at 30°C water temperature. Under the same conditions, it significantly increased metabolic rates and the energetic cost of growth across development. By contrast, BPA decreased the cost of growth at cooler temperatures (24°C). BPA-mediated changes in cost of growth were not associated with mitochondrial efficiency (P/O ratios (i.e. adenosine diphosphate (ADP) used/oxygen consumed) and respiratory control ratios) although BPA did increase mitochondrial proton leak. In females, BPA decreased age at maturity at 24°C but increased it at 30°C, and it decreased the gonadosomatic index suggesting reduced investment into reproduction. Our data reveal a potentially serious emerging problem: increasing water temperatures resulting from climate warming together with endocrine disruption from plastic pollution can impact animal growth efficiency, and hence the dynamics and resilience of animal populations and the services these provide.

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Section: Discussionmentioning

confidence: 99%