The involvement of the sympathetic nervous system in the centrogenic pressor and tachycardiac effects of prostaglandins E2 and F2α in anaesthetised cats

Rao, T.S.; Seth, S D; Manchanda, S. C.; Nayar, U

doi:10.1016/0006-8993(87)91580-0

Cited by 6 publications

(4 citation statements)

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“…PGE 2 induces diverse centrally mediated effects, including fever (3) and a sympathetically mediated increase in blood pressure and heart rate (HR; 13,20,42), in adults of many species. Interestingly, PGE 2 has prominent respiratory depressant effects in the perinatal period in humans, sheep, and pigs (15,28,30), whereas it appears to have little or no central respiratory effects in adults in that intracarotid PGE 2 has little effect on arterial PCO 2 (Pa CO 2 ) in adult sheep and dogs (20).…”

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confidence: 99%

Developmental changes in respiratory, febrile, and cardiovascular responses to PGE₂ in newborn lambs

Tai

Adamson

2000

American Journal of Physiology-Regulatory, Integrative and Comp

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PGE(2) has centrally mediated respiratory, febrile, and cardiovascular effects that markedly differ between fetal and adult life. We hypothesized that the transition from fetal to adult responses to PGE(2) occurs in the newborn period. Thus effects of an intracarotid infusion of PGE(2) (3 microg/min for 60 min) were determined in unanesthetized newborn lambs at 5, 10, and 15 days after birth. At 5 days, PGE(2) reduced central CO(2) sensitivity, reduced lung ventilation due to a decrease in breathing frequency, and induced hypercapnia. By 15 days, these effects of PGE(2) had waned significantly. In contrast, phasic (expiratory) thyroarytenoid muscle electromyogram activity, number of short apneas, and incidence of Biot periodic breathing were similarly increased at all three ages. PGE(2) induced a sustained fever at 10 and 15 days. Heart rate and mean arterial blood pressure were unchanged in contrast to marked increases observed by others in adults. Results showed that the transition from fetal to adult respiratory and febrile responses to PGE(2) occurs in early postnatal life, whereas adult cardiovascular responses develop later in life in sheep.

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confidence: 99%

Developmental changes in respiratory, febrile, and cardiovascular responses to PGE₂ in newborn lambs

Tai

Adamson

2000

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Moreover, i.c.v. pretreatment with a TXA 2 synthase inhibitor (Yalcin et al 2006) (Hoffman et al 1981;Ono and Furukawa 1983;Rao et al 1987;Siren 1982c). In addition, central application of PGD 2 to the i.c.v.…”

Section: Discussionmentioning

confidence: 99%

The Intermediation Role of Central Cyclooxygenase Products Txa2, Pgf2α, Pge, and PGD in Orexin-Evoked Cardiovascular Effects

Altınbaş

2021

Izmir Democracy University Health Sciences Journal

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Centrally injected some prostaglandins (PG) and orexin (OX) produce similar cardiovascular responses.We have recently reported that both central cyclooxygenase (COX) and central lipoxygenase (LOX) enzymes mediate the cardiovascular effects of OX. In the current study, we aimed to investigate the mediating effects of thromboxane (TX) A 2 , PGD, PGE, and PGF 2a , as COX pathway subproducts known to be active in cardiovascular control, on cardiovascular responses elicited by OX. Intracerebroventricular (i.c.v.) injection of OX increased cardiovascular levels in normotensive male Sprague Dawley rats. Moreover, central pretreatment with the TXA 2 synthesis inhibitor furegrelate, PGF 2α receptor antagonist, PGF 2α -dimethylamine, PGE, and PGD receptor antagonist AH6809 partially attenuated the centrally administered OX -induced pressor and tachycardic cardiovascular responses in rats.In conclusion, our results show that i.c.v. injection of OX increases blood pressure and heart rate. Moreover, TXA 2 , PGF 2α , PGE, and PGD mediate, at least in part, the centrally applied OX -evoked pressor and tachycardic responses. The results suggest that centrally injected OX -evoked pressor and tachycardia responses may also be mediated by arachidonic acid metabolites other than TXA 2 , PGF 2α , PGE, and PGD. HighlightsCentral injection of OX augments MAP and HR.The TXA 2 mediates the OX-produced cardiovascular responses.The central PGF 2a intermediates the OX-produced cardiovascular responses.The central PGE and PGD are involved in the OX-produced cardiovascular responses. et al. 1999). On the other hand, previous studies in this research area have reported that the OX-evoked cardiovascular effects are mediated by the vasopressinergic (Al-Barazanji et al. 2001), renin-angiotensin (Lin et al. 2002), cholinergic (Antunes et al. 2001), and histaminergic systems (Jochem 2009.AA released from membrane phospholipids by activation of phospholipase A 2 (PLA 2 ) forms prostaglandins (PG) or leukotrienes via the COX or lipoxygenase LOX enzyme pathway (Smith et al. 2000;Wlodawer and Samuelsson 1973). In previous studies, researchers have documented that AA and its metabolites are involved in cardiovascular control (Tassoni et al. 2008). Centrally injected melittin, PLA 2 activator and AA increased arterial pressures in normotensive and hypotensive rats (Yalcin and Erturk 2007; Yalcin and Aydin 2009;). It could be considered that centrally injected melittin-or AA -induced cardiovascular responses are the result of possibly central COX pathway products. This is because it is known that as AA -COX pathway products centrally PGE 2 ,

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“…Its effects on the molecular level include inhibition of the activity of the nuclear factor-kappa B (NF-κB) pathway, inhibition of intestinal epithelial cell injury, inhibition of chemoattractant leukotrienes, and modulation of prostaglandin metabolism [ 6 ]. Prostaglandin administration has been shown to increase heart rate in experimental models [ 7 - 8 ]. Modulating the effect of prostaglandins may be contributory to the pathomechanism of bradycardia, as reported in our case report.…”

Section: Discussionmentioning

confidence: 99%

Mesalamine Associated Bradycardia

Krzyzak

Gupta

Antonov

et al. 2018

Cureus

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A 38-year-old female presented with an acute flare of ulcerative colitis. She was started on prednisone and mesalamine. Within 24 hours of initiating mesalamine, she developed sinus bradycardia. After holding mesalamine, the heart rate returned to normal within five days. Our case illustrates the third described case, to our knowledge, of severe sinus bradycardia secondary to mesalamine.

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The involvement of the sympathetic nervous system in the centrogenic pressor and tachycardiac effects of prostaglandins E2 and F2α in anaesthetised cats

Cited by 6 publications

References 40 publications

Developmental changes in respiratory, febrile, and cardiovascular responses to PGE₂ in newborn lambs

Developmental changes in respiratory, febrile, and cardiovascular responses to PGE₂ in newborn lambs

The Intermediation Role of Central Cyclooxygenase Products Txa2, Pgf2α, Pge, and PGD in Orexin-Evoked Cardiovascular Effects

Mesalamine Associated Bradycardia

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The involvement of the sympathetic nervous system in the centrogenic pressor and tachycardiac effects of prostaglandins E2 and F2α in anaesthetised cats

Cited by 6 publications

References 40 publications

Developmental changes in respiratory, febrile, and cardiovascular responses to PGE2 in newborn lambs

Developmental changes in respiratory, febrile, and cardiovascular responses to PGE2 in newborn lambs

The Intermediation Role of Central Cyclooxygenase Products Txa2, Pgf2α, Pge, and PGD in Orexin-Evoked Cardiovascular Effects

Mesalamine Associated Bradycardia

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Developmental changes in respiratory, febrile, and cardiovascular responses to PGE₂ in newborn lambs

Developmental changes in respiratory, febrile, and cardiovascular responses to PGE₂ in newborn lambs