“…This difference between the 2 environments was significant (P<.01) with the 2 lower levels of iodine, but there was no significant difference between environments at the 2 higher levels. In addition, the iodine requirement for normal thyroid size was in excess of 75 ppb, but not more than 150 ppb, at 21 C, whereas 75 ppb appeared adequate for normal thyroid size at 32 C. The results at 21 C agree with previous work (Creek et al, 1957) where thyroid enlargement was observed with 75 ppb iodine, but not with 150 ppb.…”