We use multiple instruments data to investigate the behavior of the equatorial and low‐latitude ionosphere during the geomagnetically active and quiet period of November 1–6, 2021. In this context, total electron content (TEC) data obtained from the Global Positioning System (GPS) receivers in the equatorial and low‐latitude regions of Asia, Africa, and America are used to assess variations in plasma density during the storm. The storm‐time ionization levels were found to vary significantly in the crests of the Equatorial Ionization Anomaly (EIA) region over the 3 longitudes. The Rate of Change TEC Index (ROTI) derived from GPS receiver measurements, is used to study the equatorial/low‐latitude ionospheric plasma irregularities at various longitudes under geomagnetically quiet and disturbed conditions. Observations showed longitudinal variations in the ionospheric irregularities under both quiet and disturbed conditions. Some days exhibit a decrease in the strength of the midnight plasma irregularities toward the East, that is, the irregularities are more pronounced in West America, less common in East America, and almost non‐existent in Africa and Asia. Our investigations show this storm prevented the occurrence of plasma irregularities at the equatorial/low‐latitude region in the American sector during the night following the main phase. In general, no significant storm effects were observed at the target locations in Africa and Asia. The existence of westward Prompt Penetration Electric Field (PPEF) and the Equatorial Electrojet (EEJ) during the main phase, from midnight to noon, is clearly related with the constriction of plasma diffusion and the consequent suppression of plasma irregularities. Thus, the longitudinal dependence for the generation of midnight plasma irregularities during this storm is mainly influenced by local time occurrence of maximum ring current, and the ionospheric electric fields.