2021
DOI: 10.1016/j.inoche.2021.108447
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The iron oxide/polymer nanocomposites for targeted drug delivery and toxicity investigation on zebra fish (Danio rerio)

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Cited by 18 publications
(4 citation statements)
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“…Although NanoMIL-89 did not significantly affect the CO, SV, ventricular volume, and EF functions, a minor significant dose-dependent increase was observed in the treated ZF embryos heartbeats (> 190 bpm). A similar effect was reported in a previous study by Rajesh et al, where iron oxide nanocomposites were shown to induce tachycardia in ZF embryos in a dose-dependent manner [57] .
Fig.
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Section: Resultssupporting
confidence: 88%
See 1 more Smart Citation
“…Although NanoMIL-89 did not significantly affect the CO, SV, ventricular volume, and EF functions, a minor significant dose-dependent increase was observed in the treated ZF embryos heartbeats (> 190 bpm). A similar effect was reported in a previous study by Rajesh et al, where iron oxide nanocomposites were shown to induce tachycardia in ZF embryos in a dose-dependent manner [57] .
Fig.
…”
Section: Resultssupporting
confidence: 88%
“…Hatching is a crucial stage of ZF embryogenesis, and a delayed hatching rate indicates a stress response due to a possible disturbance in the anatomy or physiology of the ZF embryos development [55] , [56] . In line with other studies, the organic linkers and iron oxide composites of MOFs nanoparticles can impact the activity of the chorionase enzyme and cause an osmotic disturbance, which in turn contributes to the delay of the ZF hatching process [21] , [26] , [57] . Moreover, the adherence and agglomeration of nanoMIL-89 on the chorion surface cause oxygen depletion and hypoxia, which may delay the hatching of ZF embryos and development [21] , [58] .…”
Section: Resultssupporting
confidence: 85%
“… 118 Bacterial nanocellulose was also employed as a virus antigen carrier for vaccination and an improvement in immune-related genes was observed. 119 Additionally, chitosan-based materials have been used for different medical purposes like wound healing, 120 drug delivery, 121 and anticancer activity. 122 Nevertheless, it is difficult to conclude that polymers are always non-toxic.…”
Section: Potential Impacts Of Polymer-based Nanocomposite Adsorbents ...mentioning
confidence: 99%
“…Polymer composites have found applications in a large variety of areas, ranging from the generation of portable electronic devices and high-speed integrated circuits ( Deshmukh et al, 2017 ; Zhang et al, 2002 ) to the development of drug delivery systems ( Lai et al, 2018 ; Lopez-Lugo et al, 2021 ; Rajesh et al, 2021 ). This is partially attributed to good processability and high structural flexibility of polymer composites ( Chen et al, 2015 ; Choudhary and Sengwa, 2017 ; Dang et al, 2012 ; Xu et al, 2017 ).…”
Section: Introductionmentioning
confidence: 99%