1994
DOI: 10.1073/pnas.91.26.12994
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The iron-responsive element binding protein: a target for synaptic actions of nitric oxide.

Abstract: Molecular targets for the actions of nitric oxide (NO) have only been partially darified. The dynamic properties of the iron-sulfur (Fe-S) cluster of the iron responsive-element binding protein (IRE-BP) suggested that it might serve as a target for NO produced in response to glutamatergic stimulation in neurons. In the present study, we demonstrate that N-methyl-D-aspartate, acting through NO, stimulates the RNA-binding function of the IRE-BP in brain slices while diminishing its aconitase activity. In additio… Show more

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Cited by 75 publications
(30 citation statements)
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“…In addition, we showed that inhibition of mitochondrial aconitase was rapidly reversible (6). Subsequently, we and others demonstrated that NO synthesis increases IRE binding in several cell types (7)(8)(9). Conversely, NO synthesis causes loss of aconitase activity of IRP as shown for mitochondrial aconitase (7,9).…”
Section: Iron Regulatory Protein (Irp)mentioning
confidence: 93%
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“…In addition, we showed that inhibition of mitochondrial aconitase was rapidly reversible (6). Subsequently, we and others demonstrated that NO synthesis increases IRE binding in several cell types (7)(8)(9). Conversely, NO synthesis causes loss of aconitase activity of IRP as shown for mitochondrial aconitase (7,9).…”
Section: Iron Regulatory Protein (Irp)mentioning
confidence: 93%
“…It must be recalled that some NO synthase product(s) can alter IRP in living cells sufficiently to change both its functions reciprocally (7,9). The exact nature of the NO synthase product which metamorphoses IRP into IRE-binding protein is still open to question.…”
Section: Fig 8 Effect Of Nitrosothiols On Ire Binding Activity Of Irpmentioning
confidence: 99%
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“…The only delay may arise from the requirement to induce NOS2. However, this drawback can be bypassed if one of the constitutive NO synthases (NOS1 and NOS3) is concerned, as already shown in neurons (55) or in the case of closeness to NOS2-expressing cells, as shown in our coculture model.…”
Section: Fig 6 Effect Of Cycloheximide On Ire Binding Activities Ofmentioning
confidence: 96%
“…Potential interactions involving eIF2 could be with Met-tRNA, or with rRNA within the 40s ribosomal subunit as well as with mRNA. However, in yeast, mutations in each of the three subunits of eIF2 have been found to influence the fidelity of the interaction of the MettRNA, anticodon with codons serving as initiation codons [20,25,261. The primary sequence of the a subunit of eIF2 reveals no consensus motifs connected with ligand binding; the most significant feature of this polypeptide is a conserved phosphorylation site (Ser51 in mammalian cells), which is the target for a family of protein kinases important in the regulation of protein synthesis (see below).…”
Section: Formation Of the 43s Preinitiation Complexmentioning
confidence: 99%