The Iron Stimulon and Fur Regulon of Geobacter sulfurreducens and Their Role in Energy Metabolism

Embree, Mallory; Qiu, Yu; Shieu, Wendy; Nagarajan, Harish; O'Neil, Regina A.; Lovley, Derek R.; Zengler, Karsten

doi:10.1128/aem.03916-13

Cited by 37 publications

(40 citation statements)

References 52 publications

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“…Fur regulates genes by either directly binding to their promoter sequences or indirectly by recruiting small regulatory RNA which then regulate gene expression (82, 84, 85, 87, 88). The Fur regulon has been described for several bacteria including genes regulated by Fur under iron limiting or excess iron conditions (68, 79, 80, 82, 89, 90). Interestingly, our results also showed that carbapenem production by Pcb 1692 is dependent on iron and regulated by Fur.…”

Section: Discussionmentioning

confidence: 99%

The impact of type VI secretion system, bacteriocins and antibiotics on competition amongst Soft-RotEnterobacteriaceae: Regulation of carbapenem biosynthesis by iron and the transcriptional regulator Fur

Nkomo

et al. 2018

Preprint

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17Plant microbial communities' complexity provide a rich model for investigation on biochemical and 18 regulatory strategies involved in interbacterial competition. Within these niches, the soft rot 19 Enterobacteriaceae (SRE) comprise an emerging group of plant-pathogens inflicting soft rot/black-20 leg diseases and causing economic losses worldwide in a variety of crops. In this report, a range of 21 molecular and computational techniques are utilized to survey the contribution of antimicrobial 22Pcb1692 inhibits growth of other SRE and several potato endophytes using either the type VI 51 secretion, carbapenem or bacteriocins. Carbapenem plays a role in both inter and intrabacterial 52 competition in vitro, while the Pcb1692T6SS plays a role in interbacterial competition in planta (in 53 potato tubers). We also demonstrate that carbapenem regulation requires the presence of 54 environmental iron and oxygen in a complex network consisting of Pcb1692 Fur, SlyA, and ExpI. 55

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Section: Discussionmentioning

confidence: 99%

The impact of type VI secretion system, bacteriocins and antibiotics on competition amongst Soft-RotEnterobacteriaceae: Regulation of carbapenem biosynthesis by iron and the transcriptional regulator Fur

Nkomo

et al. 2018

Preprint

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“…and Geobacter spp. both have functional iron transport and regulation systems for intracellular iron homeostasis (37, 38). EET can function by both direct electron transfer (DET), which involves outer membrane c-type cytochromes (39) and mediated electron transfer (MET), which avails of microbially produced redox mediators (40-43).…”

Section: Resultsmentioning

confidence: 99%

Extracellular Electron Transfer PowersEnterococcus faecalisBiofilm Metabolism

Keogh

Lam

Doyle

et al. 2017

Preprint

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“…Nevertheless, despite Fur's involvement in energy metabolism, an alternative transcriptional regulator by IdeR showed that this bacterium is able to overcome environments with fluctuating iron concentrations and to maintain tight and deliberate control over intracellular iron homeostasis (Embree et al 2014). …”

Section: Iron Homeostasis Regulationmentioning

confidence: 98%

“…This requires the ligation of a metal, usually Fe(II), as a co-factor or co-repressor (Escolar et al 1999;Fillat 2014;Ratledge and Dover 2000). The interaction with DNA confers to the Fur protein the ability to regulate the expression of the genes that encode not only the proteins involved in the ABC-transporter systems but also the iron storage proteins such as the aforementioned ferritins (Embree et al 2014).…”

Section: Iron Homeostasis Regulationmentioning

confidence: 98%

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Iron management and production of electricity by microorganisms

Folgosa

Tavares

2015

Appl Microbiol Biotechnol

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The increasing dependency on fossil fuels has driven researchers to seek for alternative energy sources. Renewable energy sources such as sunlight, wind, or water are the most common. However, since the 1990s, other sources for energy production have been studied. The use of microorganisms such as bacteria or archaea to produce energy is currently in great progress. These present several advantages even when compared with other renewable energy sources. Besides the energy production, they are also involved in bioremediation such as the removal of heavy metal contaminants from soils or wastewaters. Several research groups have demonstrated that these organisms are able to interact with electrodes via heme and non-heme iron proteins. Therefore, the role of iron as well as iron metabolism in these species must be of enormous relevance. Recently, the influence of cellular iron regulation by Fur in the Geobacter sulfurreducens growth and ability to produce energy was demonstrated. In this review, we aim to briefly describe the most relevant proteins involved in the iron metabolism of bacteria and archaea and relate them and their biological function with the ability of selected organisms to produce energy.

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The Iron Stimulon and Fur Regulon of Geobacter sulfurreducens and Their Role in Energy Metabolism

Cited by 37 publications

References 52 publications

The impact of type VI secretion system, bacteriocins and antibiotics on competition amongst Soft-RotEnterobacteriaceae: Regulation of carbapenem biosynthesis by iron and the transcriptional regulator Fur

The impact of type VI secretion system, bacteriocins and antibiotics on competition amongst Soft-RotEnterobacteriaceae: Regulation of carbapenem biosynthesis by iron and the transcriptional regulator Fur

Extracellular Electron Transfer PowersEnterococcus faecalisBiofilm Metabolism

Iron management and production of electricity by microorganisms

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