The IS
            <i>200</i>
            /IS
            <i>605</i>
            Family and “Peel and Paste” Single-strand Transposition Mechanism

He, Shuhua; Corneloup, Alix; Guynet, Catherine; Lavatine, Laure; Caumont-Sarcos, Anne; Siguier, Patricia; Marty, B.; Dyda, Fred; Chandler, Michaël; Hoang, Bao Ton

doi:10.1128/microbiolspec.mdna3-0039-2014

Cited by 64 publications

(27 citation statements)

References 65 publications

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“…ISs are prokaryotic transposable elements with a simple organization: two terminal inverted repeats (IR) flanking a transposase-coding gene, with certain exceptions such as those of the IS 200 /IS 605 family that display sub-terminal palindromic structures [41]. ISs are ubiquitous among prokaryotic genomes, with a differentiated distribution between chromosomes and plasmids [42, 43].…”

Section: Introductionmentioning

confidence: 99%

Diversity of Bacillus cereus sensu lato mobilome

2019

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Background Bacillus cereus sensu lato s.l. ) is a group of bacteria displaying close phylogenetic relationships but a high ecological diversity. The three most studied species are Bacillus anthracis, Bacillus cereus sensu stricto and Bacillus thuringiensis . While some species are pathogenic to mammals or associated with food poisoning, Bacillus thuringiensis is a well-known entomopathogenic bacterium used as biopesticide worldwide. B. cereus s.l. also contains a large variety of mobile genetic elements (MGEs). Results In this study, we detail the occurrence and plasmid vs. chromosome distribution of several MGEs in 102 complete and annotated genomes of B. cereus s.l. These MGEs include 16 Insertion Sequence (IS) families, the Tn 3 family, 18 different Bacillus cereus repeats ( BCRs ) and 30 known group II introns. Conclusions Our analysis not only shows the diversity of these MGEs among strains of the same species and between different species within the B. cereus s.l. group, but also highlights the potential impact of these elements on the plasticity of the plasmid pool, and the TEs (Transposable Elements) - species relationship within B. cereus s.l. Electronic supplementary material The online version of this article (10.1186/s12864-019-5764-4) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Diversity of Bacillus cereus sensu lato mobilome

2019

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“…Apart from their involvement in replication and conjugation, HUH endonucleases can also act as transposases for (i) IS 91 , ISCR and helitrons, (ii) IStrons – mosaic elements combining the features of TEs and introns ( Tourasse et al, 2014 ), and (iii) repetitive extragenetic palindromes (REP) classified as bacterial interspersed mosaic elements (BIMEs) ( Ton-Hoang et al, 2012 ). However, not all transposases containing the HUH motif perform RCT, e.g., those belonging to the IS 200 -IS 608 bacterial transposon family ( He et al, 2015 ).…”

Section: Characteristics Of Rcr Initiator Proteinsmentioning

confidence: 99%

The Different Faces of Rolling-Circle Replication and Its Multifunctional Initiator Proteins

2017

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Horizontal gene transfer (HGT) contributes greatly to the plasticity and evolution of prokaryotic and eukaryotic genomes. The main carriers of foreign DNA in HGT are mobile genetic elements (MGEs) that have extremely diverse genetic structures and properties. Various strategies are used for the maintenance and spread of MGEs, including (i) vegetative replication, (ii) transposition (and other types of recombination), and (iii) conjugal transfer. In many MGEs, all of these processes are dependent on rolling-circle replication (RCR). RCR is one of the most well characterized models of DNA replication. Although many studies have focused on describing its mechanism, the role of replication initiator proteins has only recently been subject to in-depth analysis, which indicates their involvement in multiple biological process associated with RCR. In this review, we present a general overview of RCR and its impact in HGT. We focus on the molecular characteristics of RCR initiator proteins belonging to the HUH and Rep_trans protein families. Despite analogous mechanisms of action these are distinct groups of proteins with different catalytic domain structures. This is the first review describing the multifunctional character of various types of RCR initiator proteins, including the latest discoveries in the field. Recent reports provide evidence that (i) proteins initiating vegetative replication (Rep) or mobilization for conjugal transfer (Mob) may also have integrase (Int) activity, (ii) some Mob proteins are capable of initiating vegetative replication (Rep activity), and (iii) some Rep proteins can act like Mob proteins to mobilize plasmid DNA for conjugal transfer. These findings have significant consequences for our understanding of the role of RCR, not only in DNA metabolism but also in the biology of many MGEs.

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“…Specifically, H. pylori is naturally competent for transformation and highly recombination-proficient, so that exchange of chromosomal DNA fragments between strains is frequent and highly efficient. Moreover, classical mobile genetic elements, such as plasmids (Höfler et al, 2004), phages (Vale and Lehours, 2018), transposable elements (Kersulyte et al, 1998;He et al, 2015), or genome islands, are present in the H. pylori population as well.…”

Section: Introductionmentioning

confidence: 99%